Stephen W. Chensue, M.D, Ph.D.
Associate Professor of Pathology
Campus Address: 
M5240 Medical Science I 0602
Ann Arbor, Michigan  48109-0602
Phone:   734/761-7947
schensue@umich.edu

Clinical Interests | Research Interests | Biography | Publications

Departmental Annual Report

2000-2001 | 1999-2000

Clinical Interests

Pathology

Research Interests

Cytokine/chemokine regulation of chronic inflammation.

For more information about Dr. Chensue's Research Interests.

Brief Biography

Dr. Chensue earned both his undergraduate and Ph.D. (in the field of Immunology and Microbiology) degrees at Wayne State University, Detroit, Michigan, and his M.D. degree at the University of Michigan Medical School, Ann Arbor, Michigan, in 1974, 1978, and 1983, respectively. He performed his residency in the Department of Pathology at the University of Michigan from 1983-1987, as well as a Postdoctoral Fellowship from 1985-1987.

Following that training, Dr. Chensue joined the faculty of the Department of Pathology at the University of Michigan as an Associate Professor in 1987 and became a Staff Pathologist, Chief Grade, at the Veterans Affairs Health Care System, Ann Arbor, Michigan, in the same year. In 1993, he also was appointed an Adjunct Assistant Professor in the Department of Epidemiology, School of Public Health, at the University of Michigan. Dr. Chensue was promoted to Associate Professor of Pathology in 1994. In 2001 he was appointed Chief of Pathology and Laboratory Medicine at the Ann Arbor VAHCS.

Dr. Chensue's research interests involve immune and inflammatory responses and how cytokines and chemokines mediate those responses. Along with his research activities, he has served on the editorial boards for the American Journal of Pathology, American Journal of Respiratory Cell and Molecular Biology, Journal of Immunology, and Inflammation Research.

Selected Publications

Shang X, Qiu B, Frait KA, Hu JS, Sonstein J, Curtis JL, Lu B, Gerard C, Chensue SW. Chemokine receptor 1 knockout abrogates natural killer cell recruitment and impairs type-1 cytokines in lymphoid tissue during pulmonary granuloma formation. Am J Pathol 2000, 157:2055-2063.

Ruth JH, Warmington KS, Shang X, Lincoln P, Evanoff H, Kunkel SL, Chensue SW. Interleukin-4 and -13 participation in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation: Multiparameter analysis of cellular recruitment, chemokine expression and cytokine networks. Cytokine 2000, 12:432-444.

Chensue SW, Lukacs NW, Yang TY, Shang X, Frait KA, Kunkel SL, Kung T, Wiekowski MT, Hedrick JA, Cook DN, Zingoni A, Narula SK, Zlotnik A, Barrat FJ, O'Garra A, Napolitano M, Lira SA. Aberrant in vivo T helper type-2 cell response and impaired eosinopil recruitment in CC chemokine receptor 8 knockout mice. J Exp Med 2001, 193:573-584.

Tkachuk AN, Moormann AM, Poore JA, Rochford RA, Chensue SW, Mwapasa V, Meshnick SR. Malaria enhances expression of CC cheomkine receptor 5 on placental macropahges. J Infect Dis 2001, 183:967-972.

Qiu B, Reich F, Frait KA, Reich F, Komuniecki E, Chensue SW. Chemokine expression dynamics in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation. Am J Pathol 2001, 158:1503-1515.