|
Gregory R. Dressler, Ph.D. Campus Address: |
|
|
|
|
Departmental Annual Report1999-2000 |
|
|
BiographyDr. Dressler earned both his undergraduate and Ph.D. (Genetics/Molecular Biology) degrees at the University of Pennsylvania, Philadelphia, Pennsylvania in 1981 and 1986, respectively. He then served, from 1987-1989, as a Postdoctoral Fellow at the Max Planck Institute for Biophysical Chemistry, Goettingen, Germany. From 1990 in 1994, he was a Senior Staff Fellow at the Laboratory of Mammalian Genes and Development at the National Institute of Child Health and Human Development, Bethesda, Maryland from 1990-1994. Dr. Dressler came to the faculty of the Department of Pathology at the University of Michigan as an Assistant Professor in 1994, where he is also an Assistant Investigator at the Howard Hughes Medical Institute at the University of Michigan. In addition, he currently serves as the Interim Co-Director of the Center for Organogenesis. The main areas of interest for Dr. Dressler involve the genetic basis of mammalian development. More specifically, the lab utilizes the mammalian kidney to study transcription factors and cell signaling molecules that specify the differentiation of the renal epithelium. How developmental regulatory genes contribute to renal disease is also of interest. Recent Publications Ostrom, L., Tang, M.-J., Gruss, P., and Dressler, G.R. (2000) Reduced Pax2 gene dosage increases apoptosis and slows the progression of renal cystic disease. Dev. Biol. 219, 250-258 Mah, S.P., Saueressig, H., Goulding, M., Kintner, C., and Dressler, G.R. (2000) Kidney Development in Cadherin-6 Mutants: Delayed Mesenchyme-to-Epithelial Conversion and Loss of Nephrons. Dev. Biol.223, 38-53. Lechner, M.S. and Dressler, G.R. (2000) PTIP: A novel BRCT-domain protein interacts with the Pax family of transcription factors. Nuc. Acids Res. 28, 2741-2751. Brophy, P.D., Ostrom, L., Lang, K.M. and Dressler, G.R. (2001) Regulation of ureteric bud outgrowth by Pax2 dependent activation of the Glial Derived Neurotrophic Factor Gene. Development, in press Dressler, G.R. (2001) The development of the kidney, in Mouse Development: Patterning, Morphogenesis, and Organogenesis, (J. Rossant and P. Tam, eds.) Academic Press, San Diego, in press. |
|