Research Interests
Regulation
of apoptosis; control of cell survival by the tumor necrosis factor and
transforming growth factor beta-receptor superfamilies.
For more information on Dr. Duckett's Research
Interests.
Brief Biography
Dr.
Duckett received his Ph.D. from the University of London, England, during
which time he worked with Dr. Gary Nabel at the University of Michigan
on the regulation of HIV by the transcription factor NF-kB. He did postdoctoral
work at the University of Chicago with Dr. Craig Thompson, where he studied
the regulation of apoptosis, before moving to the National Cancer Institute
in 1997 as a principal investigator. He joined the Pathology Department
at the University of Michigan in 2002, where he has a joint appointment
in the Department of Medicine and is a member of the Cancer Center.
Representative
Publications
Mir,
S. S., Richter, B.W.M. and Duckett, C. S. Differential effects of CD30
activation in anaplastic large cell lymphoma and Hodgkin's disease cells.
Blood 96:4307-4312 (2000).
Larisch-Bloch, S., Yi, Y., Lotan, R., Kerner, H., Eimerl, S., Parks, W.
T., Reffey, S. B., de Caestecker, M. P., Danielpour, D., Book-Melamed,
N., Timberg, R., Duckett, C. S., Lechleider, R. J., Orly, J., Kim, S.
-J. and Roberts, A. B. A novel mitochondrial septin, ARTS, mediates apoptosis
via its P-loop motif. Nature Cell Biol 2:915-921 (2000).
Richter, B.W.M and Duckett, C.S. The IAP proteins: caspase inhibitors
and beyond. Science's STKE (2000) (http://stke.sciencemag.org/cgi/content/full/OC_sigtrans%3b2000/44/pe1)
(2000).
Richter, B.W.M., Mir, S.S., Eiben, L.J., Lewis, J, Frattini, A., Tian,
L., Frank, S., Youle, R.J., Nelson, D.L., Notarangelo, L.D., Vezzoni,
P., Fearnhead, H.O. and Duckett, C.S. Molecular cloning of ILP-2, a novel
member of the inhibitor of apoptosis protein (IAP) family. Mol. Cell.
Biol. 21:4292-4301 (2001).
Reffey, S.B., Wurthner, J.U, Parks, W.T., Roberts, A.B and Duckett, C.S.
X-linked inhibitor of apoptosis protein functions as a cofactor in transforming
growth factor- signaling. J. Biol. Chem. 276:26542-26549 (2001).
Richter, B.W. M, Lewis, J., Mir, S.S., Reffey, S.B., Eiben, L.J. and Duckett,
C.S. VIAF, a highly conserved regulator of apoptosis that interacts with
IAP proteins. Submitted.
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