Professor
Campus Address:
7520 MSRBI
1301 Catherine Road
Ann Arbor, Michigan 48109-0602
Phone: 734/747-2921
kjjkjj@umich.edu
Annual Report | Biography | Clinical Interests | Research Interests | Selected Publications
Departmental Annual Report
Brief Biography
Dr. Johnson earned his undergraduate degree at the University of North Dakota, Grand Forks, North Dakota, in 1968 and his M.D. degree from the University of Connecticut Medical School, Farmington, Connecticut, in 1976. He performed his residency in the Department of Anatomic Pathology at the University of Connecticut Medical School from 1977-1979, then became an Assistant Professor in that same Department in 1979.
In 1980, Dr. Johnson moved to the University of Michigan where he became an Assistant Professor in the Department of Pathology, where he was promoted to Associate Professor in 1983 and Full Professor in 1988. He serves as the Director of the Morphology Core for the Department of Pathology.
The major areas of study for Dr. Johnson include clinical interests in the immunopathological evaluation of skin and renal biopsies, and research interests, broadly characterized, which deal with the pathogenesis of inflammation, particularly the acute inflammatory response and the role of matrix metalloproteinases in prostate cancer. These interests have led to significant NIH-sponsored research support.
Clinical Interests
Pathology, Immunopathology, and renal pathology.
Research Interests
Inflammation and oxygen radicals.
For many years our laboratory has been interested in the pathogenesis of inflammation; particularly the acute inflammatory response. Our studies are centered on the role of neutrophils and macrophages in these reactions including the recruitment of these cells into sites of inflammation, activation of these cells, and the products produced by these cells that are responsible for the tissue injury. Specific areas of study include leukocyte-derived oxidants and proteases and their role in tissue injury, the role of cytokines, and the up-regulation of adhesive interactions between leukocytes and endothelial cells. Much of our research has centered on acute lung injury, but we also have ongoing projects on the mediation of renal glomerular, as well as vascular injury.
Selected Publications
Nader, N.D., Knight, P.R., Bobela, I., Davidson, B.A., Johnson, K.J., and Morin, F.: High-dose nitric oxide inhalation increases lung injury after gastric aspiration. Anesthesiology. 1999;91(3):741-749.
Donovan, B.W., Reuter, J.D., Zhengyi, C., Andrezej, M., Johnson, K.J., and Baker Jr., J.R.: Prevention of murine influenza A viral pneumonitis by surfactant nanoemulsions. AntiViral Chemistry and Chemotherapy, Antiviral Chemistry & Chemotherapy 2000; 11:41-49.
Warner, R.L., Bless, N.M., Lewis, C.S., Younkin, E., Beltran, L., Guo, R.F., Johnson, K.J., and Varani, J.: Time-dependent inhibition of immune complex lung injury by catalase: Relationship to alterations in macrophage and neutrophil matrix metalloproteinase elaboration. Free Rad. Biol. Med., 2000; 29:8-16.
Shanley, T.P., Davidson, B.A., Nader, N.D., Bless, N., Vasi, N., Ward, P.A., Johnson, K.J., and Knight, P.R.: Role of macrophage inflammatory protein-2 in aspiration-induced lung injury. Critical Care Medicine. 2000;28(7):2437-2444.
Yung, R., Ray, D., Eisenbraun, J., Deng, C., Attwood, J., Eisenbraun, M., Johnson, K., Miller, R., Hanash, S.,and Richardson, B.: Unexpected effects of a heterozygous DNMT1 null mutation on age-dependent DNA hypomethylation and autoimmunity. J. Gerontology: Biological Sciences. 2001;56(6)B268-B276.