Selected Publications from Nuñez’s Laboratory

For a Complete list of publications, visit National Library of Medicine's PubMed site.

Wu, D., Wallen, H., Nuñez, G.: Interaction and regulation of subcellular localization of CED-4 by CED-9. Science. 275:1126-1128 (1997).

del Peso, L., Gonzalez-Garcia, M., Page, C., Herrera, R., Nuñez, G.: Interleukin-3-Induced Phosphorylation of BAD through the Protein Kinase Akt. Science. 278:687-689 (1997).

Inohara, N., Koseki, N., del Peso, L., Hu, Y., Yee, C., Chen, S., Carrio, R., Merino, J., Liu, D., Ni, J., Nuñez, G. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor kB. J Biol Chem. 274(21):14560-14567 (1999).

Hu, Y., Benedict, M.A., Ding, L., Nuñez, G. Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis. EMBO J. 18(13):3586-3595 (1999).

Inohara, N., Koseki, T., Lin, J., del Peso, L., Lucas, P.C., Chen, F.F., Ogura, Y., Nuñez, G.: An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. J Biol Chem. 275(36):27823-31 (2000).

Inohara, N., Ogura, Y., Chen, F.F., Muto, A., Nuñez, G.: Human Nod1 Confers Responsiveness to Bacterial Lipopolysaccharides. J Biol Chem. 276:2551-2554 (2001).

Ogura, Y., Inohara, N., Benito, A., Chen, F.F., Yamaoka, S., Nuñez, G.: Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NFkappaB. J Biol Chem. 276:4812-4818 (2001).

Lucas, P.C., Yonezumi, M., Inohara, N., McAllister-Lucas, L.M., Abazeed, M.E., Chen, F.F., Yamaoka, S., Seto, M., Nuñez, G.: Bcl10 and MALT1, independent targets of chromosomal translocation in MALT lymphoma,cooperate in a novel NF-kappaB signaling pathway. J Biol Chem 276:19012-19019 (2001).

Ogura, Y., Bonen, D.K., Inohara, N., Nicolae, D.L., Chen, F.F., Ramos, R., Britton, H., Moran, T, Karaliuskas, R., Duerr, R.H., Achkar, J-P., Brant, S.R., Bayless, T.M., Kirschner, B.S., Hanauer, S.B., Nuñez, G.* and Cho, J.H.* (*joint senior authors). A frameshift mutation in Nod2 associated with susceptibility to Crohn's disease. Nature 411:603-606, 2001.

McAllister-Lucas, L.M., Inohara, N., Lucas, P.C., Ruland, J., Benito, A., Li, Q., Chen, S., Chen, F.F., Yamaoka, S., Iverma, I.M., Mak, T.W. and Nuñez, G. Bimp1, a MAGUK Family Member Linking PKC Activation to Bcl10-Mediated NF-kB Induction. J Biol Chem 276:30589-97 (2001).

Inohara, N., Ogura, Y., Fontalba, A., Gutierrez, O., Pons, F., Crespo, J., Fukase, K., Inamura, S., Kusumoto, S., Hashimoto, M., Foster, S.J., Moran, A.P., Fernandez-Luna, J.L., Nuñez, G. Host recognition of bacterial muramyl dipeptide mediated through NOD2: implications for Crohn's disease. J Biol Chem 278:5509-55012 (2003)

Chamaillard M, Hashimoto M, Horie Y, Masumoto J, Qiu S, Saab L, Ogura Y, Kawasaki A, Fukase K, Kusumoto S, Valvano MA, Foster SJ, Mak TW, Nuñez G, Inohara N. An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol, 4:702-707, 2003.

Tanabe T, Chamaillard M, Ogura Y, Zhu L, Qiu S, Masumoto J, Ghosh P, Moran A, Predergast MM, Tromp G, Williams CJ, Inohara N, Nuñez G. Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition. EMBO J. 7; 23:1587-1597 (2004).

Dowds TA, Masumoto J, Zhu L, Inohara N, Nuñez G . Cryopyrin induced IL-1 secretion in monocytic cells: Enhanced activity of disease-associated mutants and requirement for ASC. J Biol Chem 279:21924-21928 (2004).

Kobayashi KS, Chamaillard M, Ogura Y, Henegariu O, Inohara N, Nuñez G* , Flavell RA* (* joint senior authors). Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science. 307:731-4 (2005).

Kanneganti T-D, Özören N, Body-Malapel M, Amer A, Park J-P, Franchi L, Whitfield J, Barchet W, Colonna M, Vandenabeele P, Bertin J, Coyle A, Grant EP, Akira S, Núñez G. Bacterial RNA and Small Antiviral Compounds Activate Caspase-1 Through Cryopyrin/Nalp3. Nature 440:223-236 (2006).

Özören N, Masumoto J, Franchi L, Kanneganti T-D, Body-Malapel M, Ertürk I*, Jagirdar R, Zhu L, Inohara N, Bertin J, Coyle A, Grant EP, and Núñez G. Distinct Roles of TLR2 and the Adaptor ASC in IL-1b/IL-18 Secretion in response to Listeria monocytogenes. J. Immunol 176:4337-4342 (2006).

Franchi L, Amer A, Body-Malapel M, Kanneganti TD, Ozoren N, Jagirdar R, Inohara N, Vandenabeele P, Bertin J, Coyle A, Grant EP, Núñez G. Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat Immunol. 7:576-582 (2006).