Felix de la Iglesia, M.D.

Felix A. de la Iglesia, M.D. Adjunct Professor Campus Address: MSRB-1 7520A 1301 Catherine Road Ann Arbor, Michigan 48109-2029 Phone: 734/647-2937 delaigf@med.umich.edu

Departmental Annual Report 2000-2001
Research Interests Liver cell toxicity, coherent multispectral fluorescence analysis of cell function. Coherent multispectral fluorescence analysis of cell function provides a new tool to dissect altered pathways and to recognize disease or toxicity mechanisms. Using live human or animal liver cells, this approach contributes to understanding and predicting hepatic side effects from therapeutic agents, particularly in disease groups where patients receive several concomitant medications. The multispectral fluorescence analysis includes panels of molecular probes specific for metabolic and excretory functions aimed to develop new clinical laboratory tests. Recent Publications F. A. de la Iglesia, J.R. Haskins and G. Feuer. Hepatotoxicity of Cardiovascular and Antidiabetic Drugs. In: Drug-Induced Liver Disease. N. Kaplovitz (Ed.) Marcel Dekker (publ.) New York, (In press) 2001. J.R. Haskins, P. Rowse, R, Rhabari, F.A. de la Iglesia. Thiazolidinedione Toxicity to Isolated Hepatocytes Revealed by Coherent Multiprobe Fluorescence Microscopy and Correlated with Multiparameter Flow Cytometry of Peripheral Leukocytes. Archives of Toxicology, In Press, 2001. S. J.Bulera, S. M. Eddy, E. Ferguson, T. A. Jatkoe, J. Reindel M.R. Bleavins, F.A. de la Iglesia. RNA Expression in the Early Characterization of Hepatotoxicants by High Density DNA Microarrays. Hepatology, 33: 1239-1258, 2001. S.J. Bulera, T.A. Festerling, F.A. de la Iglesia. Gabapentin Activates MAP Kinase In Vivo and In Vitro in Pancreatic Acinar Cells from Wistar Rats: A Postulated Mechanism for Pancreatic Acinar Tumor Formation. Toxicological Sciences, In Press, 2001. L. Dethloff, B. Barr, L. Bestervelt, S. Bulera, R. Sigler, M. LaGattuta, F. de la Iglesia. Gabapentin-Induced Mitogenic Activity in Rat Pancreatic Acinar Cells. Toxicological Sciences 55: 52-59, 2000. Brief Biography Dr. de la Iglesia graduated from the National University of Cordoba, Argentina and undertook postgraduate training at the University of Toronto, Canada. He was Director of the Warner Lambert Research Institute of Canada and in 1977 moved to Parke-Davis Research in Ann Arbor, where he became Vice President of Pathology and Experimental Pathology until his retirement in 2000. In addition to being Adjunct Professor of Pathology, he is Adjunct Professor of Toxicology at the School of Public Health and Professor of Pathology at the University of Toronto. He was founder and Co-Director, with Dr. Ward, Genomic Pathology Laboratory in the Department of Pathology. He is a Fellow of the Academy of Toxicological Sciences and has published numerous articles and books, mainly on toxicologic pathology and liver toxicity. At present he is involved in starting a cell toxicity laboratory using advanced fluorescence microscopic techniques.