Our principle focus is the study of lymphocyte recirculation and migration. Current projects include: (1) the functional characterization of the lymphocyte and endothelial receptors which mediate migration into lymphoid organs and sites of chronic inflammation; (2) investigation of the role of lymphocyte homing receptors in the hematogenous dissemination of lymphoid malignancies; and (3) investigation of the role of migration. Investigators will have the opportunity to study a variety of general topics in cell biology, including mechanisms of intercellular adhesion, the biology of mammalian carbohydrate-binding molecules (lectins), the molecular basis of organ selective lymphocyte recirculation, cell-extracellular matrix interactions, the metastatic process and mechanisms of immunologically-mediated tumor cell lysis. Investigators will be exposed of a wide variety of techniques in cell and cancer biology, including automated flow cytometry, hybridoma technology, tissue culture, in vivo and in vitro measurements of cellular migratory activity and quantitative measurements of the metastatic process.

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