Michael Bachman, M.D., Ph.D., Assistant Professor. The immune response to bacterial iron metabolism.
Jason X. Cheng, M.D., Ph.D., Assistant Professor. Epigenetic and genetic controls of both normal and abnormal hematopoiesis, especially, myelopoiesis. New technologies for genome-wide profiling of epigenetic biomarkers/signatures and exploring their potential usages in clinical diagnosis, prognosis and management of myelodysplastic syndrome (MDS), leukemias and other diseases. Pathogenetic mechanisms underlying epigenetic alterations in MDS, leukemia and bone marrow diseases.
Stephen
W. Chensue, M.D., Ph.D., Professor. Cellular and molecular
mechanisms of leukocyte mobilization during granulomatous inflammation.
Arul
Chinnaiyan, M.D., Ph.D., S.P. Hicks Endowed Professor of Pathology and Professor of Urology; Investigator, Howard Hughes Medical Institute. Prostate and Breast Cancer, Genomics, Proteomics, Metabolomics, and Bioinformatics.
Kathleen
R. Cho, M.D., Professor. Molecular pathogenesis of gynecological
tumors.
Tomasz Cierpicki, Ph.D., Assistant Professor. Structural studies of proteins involved in leukemogenesis. Development of small molecule compounds targeting protein-protein interactions relevant to leukemogenic transformation.
Yali Dou, Ph.D., Assistant Professor. Epigenetic regulation by histone modifying enzymes in mammals.
Gregory
Dressler, Ph.D., Professor. Genetic basis of cellular differentiation and
pattern formation in a complex multicellular tissue.
Colin
S. Duckett, Ph.D., Professor. Regulation of apoptosis,
control of cell survival by the tumor necrosis factor and transforming
growth factor beta receptor superfamilies.
Kojo Elenitoba-Johnson, M.D., Henry Clay Bryant Professor and Director, Division of Translational Pathology. Hematologic malignancies.
Eric R. Fearon, M.D., Ph.D., Professor, Departments of Internal Medicine, Human Genetics, and Pathology. Tumor suppressor gene pathways in normal cell growth and differentiation, and the role of mutations in these pathways cancer.
David
O. Ferguson,
M.D., Ph.D., Associate Professor. DNA repair and genomic stability
in mammals. Our focus is understanding how DNA repair prevents
cancer through maintenance of genomic stability, and how it ensures
proper development. Visit http://www.pathology.med.umich.edu/fergusonlab/
Maria E. Figueroa, M.D., Assistant professor. Role of DNA methylation in transcriptional regulation during normal and malignant hematopoiesis. Genomics and epigenomics. Characterization of epigenetic changes in the bone marrow during differentiation and aging.
Jason
E. Gestwicki, Ph.D., Assistant Professor. Chemical biology;
small molecule inhibitors of protein-protein interactions; controlling
subcellular location of proteins with molecular machines; developing
new therapeutic strategies.
Jolanta Grembecka, Ph.D., Assistant Professor. Development of small molecules for targeted therapies in cancer, with a particular focus on proteins involved in leukemogenesis.
Jay
H. Hess, M.D., Ph.D., Carl V. Weller Professor and Chair.
Transcriptional regulation, epigenetics, mixed lineage leukemia,
histone methyltransferases, microarray, bioinformatics.
Cory
Hogaboam, Ph.D., Professor. Chemokine contribution
to chronic remodeling of the asthmatic airway in fungal asthma
model.
Evan
T. Keller, Ph.D. Professor. Immunologic aging.
Celina
G. Kleer, M.D., Associate Professor. Genetic determinants
of inflammatory breast cancer and the role of different markers
as prognosticators in breast cancer.
Steven
L. Kunkel, Ph.D., Endowed Professor in Pathology Research.
Regulation of cytokine gene expression; macrophage pathobiology.
Elizabeth R. Lawlor, M.D., Ph.D., Russell G. Adderly Professor of Pediatric Oncology and Associate Professor of Pathology and Pediatrics.
Pediatric cancer biology with a focus on Ewing sarcoma and stem cell pathway deregulation.
Andrew
P. Lieberman, M.D., Ph.D. Associate Professor. Molecular mechanisms of neurodegeneration in polyglutamine expansion diseases and Niemann-Pick type C disease.
Megan S. Lim, M.D., Ph.D., Professor and Director, Hematopathology. Hematologic malignancies.
David B. Lombard, MD, PhD, Assistant Professor. Mammalian sirtuins in metabolism and aging; mechanisms of oxidative stress resistance.
Peter
Lucas, M.D., Ph.D. Associate Professor. NF-kB signaling in vascular, metabolic, and neoplastic disease.
Nicholas
W. Lukacs, Ph.D., Professor. Cytokine/chemokine
cascades associated with allergic airway responses (asthma) and
T-lymphocyte-mediated pulmonary inflammation.
Richard
A. Miller, M.D., Ph.D., Professor. Stress resistance pathways in long-lived mutant mice and long-lived species; and signal transduction in aging T cells.
Hedwig
Murphy, M.D., Ph.D., Associate Professor. Endothelial cell responses
in inflammation studied in cultured cells with emphasis on the
enzyme source of endothelial cell oxidants, the role of endothelial
cell derived oxidants in signaling and cell injury and the repertoire
of endothelial cell derived cytokines and their role in inflammation.
Alexey Nesvizhskii, Ph.D., Assistant Professor. Functional and clinical proteomics, bioinformatics, computational analysis of biological datasets, mass spectrometry data analysis.
Zaneta Nikolovska-Coleska, PhD, Assistant Professor. Discovery, design and development of small-molecules as new molecularly targeted therapies for cancer.
Gabriel
Nuñez, M.D., Paul H. DeKruif Professor. Molecular regulation
of programmed cell death (apoptosis), identification and characterization
of apoptosis regulatory genes.
Jean-Francois Rual, Ph.D., Assistant Professor. Systems-level characterization of the Notch molecular network. Research interests lie in the field of systems biology and the use of proteomic approaches to study cellular networks. Focus on systematic analysis of protein interactions in biological systems and their relationship to human disease, with particular interest in the cancer-related Notch pathway. The Rual lab uses biochemical, molecular, cell biological, and genetic means in high-throughput settings to address these questions.
Sem
H. Phan, M.D., Ph.D., Professor. Molecular and cellular mechanisms
of tissue repair and fibrosis; regulation of extracellular matrix
and cytokine gene expression; myofibroblast differentiation.
Lloyd
M. Stoolman, M.D., Professor. Lymphocyte recirculation and
migration; functional characterization of the lymphocyte and endothelial
receptors that mediate migration into lymphoid organs and sites
of chronic inflammation; role of lymphocyte homing receptors in
the hematogenous dissemination of lymphoid malignancies; role
of lymphocyte-extracellular matrix interactions in lymphocyte
migration.
James
Varani, Ph.D., Professor. Cell-substrate adhesion and cell
motility in normal mammalian cells and their malignant counterparts;
biosynthesis and surface expression of extracellular matrix molecules,
such as fibronectin, laminin, and thrombospondin and their involvement
as endogenous regulators of adhesion, motility, invasion, and
metastasis.
Peter
A. Ward, M.D., Godfrey D. Stobbe Professor. Mechanisms of
the inflammatory response and its regulation; role of oxidants
in tissue injury; mechanisms and participation of cytokines and
chemokines; role of complement activation products in the inflammatory
response.
Thomas
E. Wilson, M.D., Ph.D., Associate Professor. Normal functions
of DNA double-strand break (DSB) repair pathways and the origins
of chromosomal rearrangements associated with cancer, specifically
translocations, deletions, and amplifications.
Anuska V Andjelkovic-Zochowska,
M.D., Ph.D. Assistant Professor.
Molecular basis of inflammatory events at the blood brain barrier;
the role of vascular endothelium in the pathogenesis of central
nervous system inflammation; molecular mechanism of tumor associated
angiogenesis.
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