Research Interest:

My research focuses on the role of the Wnt/APC/ß-catenin/Tcf signaling pathway in a particular subtype of ovarian carcinomas, namely, endometrioid adenocarcinomas (OEAs). Specifically, I am working to verify this pathway’s transcriptional regulation of a candidate gene. In addition, my studies seek to explore this gene’s role in cell growth, transformation and invasion. I am also working to see how the Wnt pathway interacts with known tumor suppressor pathways to promote OEA development/progression.

Publications:

Donald R. Schwartz, Rong Wu, Sharon L. R. Kardia, Albert M. Levin, Chiang-Ching Huang, Kerby A. Shedden, Rork Kuick, David E. Misek, Samir M. Hanash, Jeremy M. G. Taylor, Heather Reed, Neali Hendrix, Yali Zhai, Eric R. Fearon, and Kathleen R. Cho. Novel Candidate Targets of ß-catenin/TCF Signaling Identified by Gene Expression Profiling of Ovarian Endometrioid Adenocarcinomas. Cancer Res 63: 2913-22.