Publications   For the most recent list of publications from the P. Ward laboratory, see the National Library of Medicine's PubMed site. Here are selected, recent publications from the laboratory: Riedemann, N.C., Guo, R.F., Neff, T.A., Laudes, I.J., Keller, K.A., Sarma, J.V., Markiewski, M.M., Mastellos, D., Strey, C.W., Pierson, C.L., Lambris, J.D., Zetoune, F.S., and Ward, P.A.: Increased C5a receptor expression in sepsis. J. Clin. Invest., 2002;110:101-108. Anaya-Prado, R., and Ramos-Kelly, J.R., Toldeo-Pereyra, L.H., Walsh, J., and Ward, P.A.: Multiple selectin blockade with a small-molecule selectin inhibitor does not affect survival after a second inflammatory challenge with nonlethal LPS. J Invest. Surg., 2002;15:171-180. Guo, R.F., Riedemann, N.C., Laudes, I.J., Sarma, V.J., Kunkel, R.G., Dilley, K.A., Paulauskis, J.D., and Ward, P.A.: Altered neutrophil trafficking during sepsis. J Immunol., 2002;169(1):307-314. Riedemann, N.C., Guo, R.F., Laudes, I.J., Keller, K., Sarma, V.J., Padgaonkar, V., and Ward, P.A.: C5a receptor and thymocyte apoptosis in sepsis. FASEB J.; 2002:16(8):887-888 Ward, P.A. and Lentsch, A.B.: Endogenous regulation of the acute inflammatory response. Molecular and Cellular Biochemistry, 2002;234/235:225-228. Beck-Schimmer, B., Madjdpour, C., Kneller, S., Ziergler, U., Pasch, T., Wuthrich, R.P., Ward, P.A., and Schimmer, R.C.: Role of alveolar epithelial ICAM-1 in lipopolysaccharide-induced lung inflammation. Eur Respir J 2002 19(6):1142-1150. Guo, R.F., and Ward, P.A.: Mediators and regulation of neutrophil accumulation in inflammatory responses in lung: Insights from the IgG immune complex model. Free Radical Biology and Medicine. 2002 33:303-310. Guo, R.F., Lentsch, A.B., Sarma, J.V., Sun, L., Riedemann, N.C., McClintock, S.D., McGuire, S.R., Van Rooijen, N., and Ward, P.A.: Activator protein-1 activation in acute lung injury. Am J Pathol. 2002 161:275-282. Anaya-Prado, R., Toledo-Pereyra, L.H., Lentsch, A.B., and Ward, P.A.: Ischemia/reperfusion injury. J Surg Res. 2002 105:248-258. McClintock, S.D., Till, G.O., Smith, M.G., and Ward, P.A.: Protection from half-mustard gas-induced acute lung injury in the rat. J Appl Toxicol. 2002 22:257-262. Riedemann NC, Ward PA: Oxidized lipid protects against sepsis. Nat Med 2002 8:1084-1085. Shanley, T.P., Zhao, B., Macariola, D.R., Denenberg, A., Salzman, A.L., Ward, P.A.: Role of nitric oxide in acute lung inflammation: Lessons learned from the inducible nitric oxide synthase knockout mouse. Crit Care Med. 2002 9:1960-1968. Huber-Lang, M.S., Younkin, E.M., Sarma, J.V., McGuire, S.R., Lu, K.T., Guo, R.F., Padgaonkar, V.A., Curnutte, J.T., Erickson, R., and Ward, P.A.: Complement-induced impairment of innate immunity during sepsis. J Immunol. 2002 169(6):3223-3231. Huber-Lang, M.S., Riedemann, N.C., Sarma, J.V., Younkin, E.M., McGuire, S.R., Laudes, I.J., Lu, K.T., Guo, R., Neff, T.A., Padgaonkar, V.A., Lambris, J.D., Spruce, L, Mastellos, D., Zetoune, F.S., and Ward, P.A.: Protection of innate immunity by C5aR antagonist in septic mice. FASEB J. 2002 (12) 1567-1574. Martinez-Mier, G., Toledo-Pereyra, L.H., McDuffie, J.E., Warner, R.L., Hsiao, C., Stapleton, S.R., and Ward, P.A.: Exogenous nitric oxide downregulates MIP-2 and MIP-1a chemokines and MAPK p44/42 after ischemia and reperfusion of the rat kidney. J Invest Surg. 2002 (15):287-296. Laudes IJ, Chu JC, Huber-Lang M, Guo RF, Riedemann NC, Sarma JV, Mahdi F, Murphy HS, Speyer C, Lu KT, Lambris JD, Zetoune FS, and Ward PA: Expression and function of C5a receptor in mouse microvascular endothelial cells. J. Immunol. 2002 169(10):5962-5970. Huber-Lang, M., Younkin, E.M., Sarma, J.V., Riedemann, N., McGuire, S.R., Lu, K.T., Kunkel, R., Younger, J.G., Zetoune F.S., and Ward, P.A.: Generation of C5a by phagocytic cells. Am. J. Pathol. 2002 161(5):1849-1859. Naidu, B., Krishnadasan, B., Whyte, R.I., Warner, R.L., Ward, P.A., and Mulligan, M.S. Regulatory role of IL-10 in experimental obliterative bronchiolitis in rats. Exp Mol Pathol 2002; 73(3): 164-170. Riedemann, N.C., and Ward, P.A.: Complement in ischemia reperfusion injury. Invited Commentary Am J Pathol. 2003 162(2): 363-367. Riedemann, N.C., Neff, T.A., Guo, R.F., Bernacki, K.D., Laudes, I.J., Sarma, J.V., Lambris, J.D., and Ward, P.A.: Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression. J Immunol. 2003 170(1): 503-507. Riedemann, N.C. and Ward, P.A.: Anti-inflammatory strategies for the treatment of sepsis. Expert Opin Biol Ther. 2003 3(2): 339-350. Riedemann, N.C., Guo, R.F., and Ward, P.A.: Novel strategies for the treatment of sepsis. Nature Med. 2003 9(5): 517-524. Huber-Lang, M.S., Sarma, J.V., McGuire, S.R., Lu, K.T., Padgaonkar, V.A., Younkin, E.M., Guo, R.F., Weber, C.H., Zuiderweg, R.R., Zetoune, F.S. and Ward, P.A.: Structure-function relationships of human C5a and C5aR. J Immunol., 2003 170(12):6115-6124. Younger, J.G., Shankar-Sinha, S., Mickiewicz, M., Brinkman, A.S., Sarma, J.V., Younkin, E.M., Standiford, T.J., Zetoune, F.S., and Ward, P.A. Complement interactions with Pseudomonas aeruginosa and their proinflammatory consequences in vivo. Am. J. Resp. Cell Mol. Biol. 2003. Riedemann, N.C., Guo, R.F., and Ward, P.A.: A key role of C5a/C5aR activation for the development of sepsis. Accepted J. Leukoc.Biol. 2003.