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JC Virus DNA by PCR, Quantitative
Soft Order Code:
Blood: Lavender top tube; CSF: sterile tube
Normal Volume:
Blood: 2 mL EDTA plasma; CSF: 2 mL
Minimum Volume:
Blood: 2 mL EDTA plasma; CSF: 2 mL
Days Set Up:
Monday - Saturday
Analytic Time:
1 day
Test Usage:
Monitoring of viral load to track the course of infection and response to treatment.
Test Methodology:
Polymerase Chain Reaction (PCR)
Additional Information:
JCV virus establishes latency in the kidney and virus is shed sporadically through life and more frequently during pregnancy or immunosuppression. JC virus causes progressive multifocal leukoencephalopathy (PML), which is a subacute demyelinating disease of the CNS and is seen mainly in advanced disseminated malignant conditions, immunodeficiency syndromes, and in immunosrppressed patients following organ transplantation. The disease PML represents a reactivation of longstanding persistent infection of the kidney and perhaps also of the brain. JC virus has also been associated with hemorrhagic cystitis, ureteral stenosis and allograft dysfunction. Test sent to Viracor-IBT Laboratories.
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Alternate Specimen:
Acceptable specimen types (1/23/12): CSF, plasma, serum, urine.
Blood: Collect specimen in a lavender top (EDTA) tube. Centrifuge and aliquot plasma into a plastic vial. Store and transport at room temperature. CSF: Send specimen frozen in a sterile tube (2 mL). The following specimen type is also acceptable: Urine (random) (2 mL in screw-capped tube, room temperature).
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