Laboratory:
Chemical Pathology
Referral Laboratory:
MiChart Code:
IgG and Albumin, CSF
Soft Order Code:
GALB
Synonyms:
Albumin, CSF Cerebrospinal Fluid IgG
CSF IgG and Albumin CSF Immunoglobulin and Albumin
IgG and Albumin, CSF Spinal Fluid Immunoglobulin and Albumin
Container:
Clean tube or container
Normal Volume:
1.0 mL CSF
Minimum Volume:
0.5 mL CSF
Offsite Collection:
Collect spinal fluid and refrigerate up to 1 week.
Onsite Collection (Michigan Medicine Hospitals Only):
Spinal fluid.
Days Set Up:
Tuesday, Friday
Analytic Time:
8 hours
Reference Range:
*Reference ranges may change over time. Please refer to the original patient report when evaluating results.
CSF IgG: 0-4.5 mg/dL; CSF Albumin: 5-34 mg/dL; CSF IgG/Albumin ratio: 0.02-0.20
Test Usage:
The level of CSF albumin is used as a reference to indicate whether an increase of the IgG is due to local secretion or to increased permeability of the blood capillaries. CSF IgG is frequently elevated in multiple sclerosis; elevations occur also in CNS syphilis, postvaccinial encephalitis, subacute sclerosing leukoencephalitis, and other primary inflammatory states of the CNS.
Test Limitations:
Normal levels do not rule out multiple sclerosis.
Test Methodology:
Turbidmetric
Additional Information:
The CSF IgG/Albumin ratio is elevated in multiple sclerosis (MS), neurosyphilis, post vaccinial encephalitis, and subacute sclerosing leukoencephalitis. High normal values may indicate degenerative diseases such as cerebral or cerebellar atrophy, amyotrophic sclerosis or brain tumor. Normal levels can occur in incomplete obstruction of the spinal canal. Increase in albumin alone can be a result of a lesion in the choroid plexus or a blockage in the flow of CSF. Electrophoretic analysis of CSF protein may show oligoclonal `bands' in cases of MS but false positive patterns also occur (e.g., absence of absolute specificity). (See Oligoclonal Bands, CSF). Determination of myelin basic protein in CSF may be of use in diagnosis of MS or other active demyelinating processes. (See Myelin Basic Protein, CSF.)
LOINC:
CSF ALB 1746-7, CSF IGG 2464-6
CPT Code:
82784 IgG, 82402 Albumin CSF
Fee Code:
21987, 22202
Test ID:
545