Figueroa Lab

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Epigenetic Regulation of Normal and Malignant Hematopoiesis

 

Contact Information
University of Michigan,
Department of Pathology,
109 Zina Pitcher Place,
Lab: BSRB 2348,
Office: BSRB 2019,
Ann Arbor, MI 48109-2200,
Lab Phone: 734-764-6925
Office Phone: 734-763-1865
Fax: 734-763-2162
The Figueroa lab studies the role of epigenetic modifications in transcriptional regulation during normal and malignant hemopoiesis. Our focus is mainly on how changes in normal DNA methylation and hydroxymethylation patterns occur during malignant transformation and how these changes may contribute to the leukemogenic process. We use a combination of computational approaches based on genome-wide next generation sequencing data as well as in vitro and in vivo modeling to determine the consequences of the epigenetic lesions that we have identified.