Pathology News

Study by Postdoc in Nusrat Lab Published in The Journal of Clinical Investigation

By Elizabeth Walker | 11 August

A study investigating fundamental mechanisms of wound healing in the gut by Miguel Quiros in Asma Nusrat’s lab entitled, “Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling” was just published in The Journal of Clinical Investigation on August 7, 2017.  

Quiros and colleagues showed that IL-10 generated by monocytes recruited into healing wounds plays a fundamental role in regulating intestinal mucosal wound repair by stimulating release of WISP-1 that, in turn, activates epithelial cell proliferative signaling pathways. These findings highlight the importance of macrophage cross-talk with epithelial cells to 
orchestrate mucosal repair after injury.

Congratulations to the investigative team!
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