Diarrhea can be the unfortunate but short-lived side effect of bad takeout food, yet it is also a leading cause of death in children under five globally. Scientists continue to investigate how illness-causing bacteria gain a foothold within the digestive tract when they are usually held in check by the protective bacteria collectively known as the gut microbiome [...]

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Congratulations to Don Giacherio, PhD, who retired July 31, 2020, following 38 years of service in the University of Michigan Department of Pathology. Giacherio completed his PhD at the University of Illinois in 1980, followed by a 2-year postdoctoral fellowship at Mayo Clinic. In 1982, Giacherio joined the University of Michigan Department of Pathology as an Instructor in Pathology, advancing to Assistant Professor in 1986. He was promoted to Clinical Associate Professor in 2004... In his retirement, Giacherio looks forward to spending more time with his family and completing his bucket list of goals he has put off too long.

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New research from the Department of Pathology and Dr. Alexandra Hristov was just published in the Journal of Cutaneous Pathology. The study focuses on the kappa and lambda immunohistochemistry in situ hybridization of atypical cutaneous lymphoid infiltrates. 

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Kathy Davis, IT Administrative Director in Pathology Informatics, retires after more than 40 years of service to the Department of Pathology. Over her career, she has contributed to lab information system software development efforts that have impacted the history of pathology informatics, both at Michigan and nationally.

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In a recently published Nature Reviews-Nephrology review article, “Digital pathology and computational image analysis in nephropathology,” Dr. Ulysses G. J. Balis discussed how the emergence of digital pathology — an image-based environment for the acquisition, management, and interpretation of pathology information supported by computational techniques for data extraction and analysis — is changing the pathology ecosystem [...]

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The University of Michigan will begin a Sampling and Testing Program of asymptomatic students, faculty and staff for the virus that causes COVID-19 on September 7.

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In a broadly collaborative effort, Pathology faculty Drs. Carl Schmidt, Jeffrey Myers, Kristine Konopka, Paul Lephart, and Teresa Nguyen joined Michigan Medicine faculty from the departments of Epidemiology, Internal Medicine, Microbiology and Immunology, Mathematics and Complex Systems, and the School of Public Health in a study published in Clinical Infectious Diseases entitled “SARS-CoV-2 surveillance in decedents in a large, urban medical examiner’s office.”

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Structural biology techniques helped researchers target the nuclear receptor-binding SET domain family, whose malfunction is associated with several types of cancer.

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"Patient advocacy and engagement is essential to provide high quality care.  Your dedication to empower other patients through education and awareness has made big contributions to the life-changing impact of patient-pathology interactions.”  So begins the award letter to Michele Mitchell from the American Society for Clinical Pathology (ASCP), who is awarding Michele the ASCP Patient Champion Award for 2020... 

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In a new study, Chan Chung et al. from the Venneti laboratory have discovered a “catch 22”-like phenomena, where epigenetic and metabolic pathways feed one another, in a childhood brain tumor called Diffuse Intrinsic Pontine Gliomas (DIPG) [...]

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When people think about forensic pathology, images of crime shows where an investigator sets out to determine a murder victim’s cause of death often come to mind. However, it’s important to acknowledge the crucial role this field actually plays in our collective response to death, especially as the COVID-19 pandemic continues to unravel...

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Dr. Vincent Laufer was recently awarded the 2020 William Boyd Medal for the Outstanding Student in Pathology. The award is given to a medical student who demonstrates outstanding expertise in all aspects of their pathology education [...]

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Dr. Celina Kleer named 2019 AACR Outstanding Investigator in Breast Cancer Research

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Dr. Aaron Udager recently appeared on Michigan Medicine's 3P's of Cancer: Prevention, Preparedness, Progress podcast

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Pathology Welcomes 8 New Residents

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New research related to H3K27M-mutant diffuse midline glioma with extensive intratumoral microthrombi in young adults with COVID-19 from the Department of Pathology was just published in Acta Neurologica. [...]

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Please welcome Dr. Pantanowitz to the Department.

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The Department of Pathology has a long history of exceptional fellowship directors and this tradition continues as we welcome five new Fellowship Directors for this academic year.

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Research from Dr. Analisa Difeo was just published in Nature Communications. The study focuses on miR-181a and how it initiates and perpetuates oncogenic transformation through the regulation of innate immune signaling [...]

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On Friday, June 19, the Department of Pathology hosted an Equality Walk at NCRC `in observance of the Juneteenth holiday. Here, members from all areas of the department gathered to show their support against racial discrimination and for the Black Lives Matter movement.

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Graduating Class of Residents.

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Graduating Class of Fellows and Clinical Lecturers.

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The publication takes an in-depth examination of diffuse alveolar damage (DAD) caused by COVID-19 and how it is morphologically indistinguishable from other causes of DAD.

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Dr. Jeffrey Myers discusses the importance of frontline workers and their caring of patients - alive or deceased - during the COVID-19 pandemic.

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The research was just published in Modern Pathology and highlights the importance of next-generation sequencing within oncogenic roles for P53 and JAK/STAT signaling in microcystic adnexal carcinomas.

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Congratulations to Thomas Annesley, PhD, on winning the 2020 IFCC Award for Distinguished Contributions in Education.

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Peter Ouillette, MT (ASCP) shares his experience working as the Department's Digital Pathology Operations Manager.

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The protein Argonaute 2 was found to be critical to the progression from benign lesions into pancreatic cancer, suggesting a therapeutic opportunity.

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The research, which focuses on invasive squamous cell carcinomas and the precursor lesions that demonstrate concordic genomic complexity in driver genes, was just published in Modern Pathology.

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Serology testing for SARS-CoV-2 is now available for ordering on appropriate patients at Michigan Medicine. A separate process for testing and screening of health care workers and Michigan Medicine affiliates will be communicated in the coming weeks.

The serology test detects specific antibodies generated as part of the immune response to SARS-COV-2 infection. Our current test methods detect  [...]

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The research was just published in Histopathology and features prominent contributions from our faculty.

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Selections will be chosen in a virtual ceremony on June 20.

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The Department of Pathology 2019 Annual Report is now available online. Our department continues to show outstanding performance and growth and the past year was another example of why our department is one of the best in the world.

In the report, you will read about [...]

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Dr. Farkash recently sat down with the podcast team to discuss renal pathology during the COVID-19 pandemic.

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The study pertains to the molecular characterization of uterine and ovarian tumors and their relationships to epithelial and germ cell features by somatic derivation.

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The study sheds light on alternative methods used for measuring size and depth of vulvar squamous cell carcinoma.

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Clinical Pathology Operations Director, Kristina Martin, MS, MLS(ASCP)^CM, has been named the recipient of the 2020 Recent Alumni Award from the Michigan State University College of Natural Science. Martin graduated from [...]

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Along with co-investigators, Sabra Djomehri, a graduate student in Celina Kleer's Laboratory, has discovered the proteomic landscape of metaplastic carcinomas, the most aggressive type of triple negative breast cancer. The study, published in [...]

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Congratulations to Arul M. Chinnaiyan, MD, PhD, on his election to the National Academy of Science!  Chinnaiyan is an investigator, Howard Hughes Medical Institute; and S.P. Hicks Endowed Professor of Pathology, American Cancer Society Research Professor, and director, Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor [...]

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A new study from the Andrew Lieberman Laboratory’s Samir Nath, et al, has discovered that MEF2 impairment underlies skeletal muscle atrophy in polyglutamine disease.

Kennedy’s Disease, also known as Spinal and Bulbar Muscular Atrophy (SBMA), is a disease caused by an inherited gene mutation that results in muscle and brain cell dysfunction. Patients progressively lose muscle mass until they are unable to walk without assistance. Ultimately [...]

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Today is Administrative Professionals Day.  A day to honor all of our amazing Admins who undergird our missions and ensure everything runs smoothly.   Thank you for all that you do!

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Researchers have uncovered the gene signature for ChRCC.

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The study details research surrounding Respiratory Syncytial Virus (RSV) among infants.

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Resolvin E1 (RvE1), a lipid derived from Omega-3 fatty acids, is a pro-repair molecule that promotes healing of intestinal wounds according to a recent study published in PNAS as a collaborative project between The Department of Pathology at the University of Michigan Medical School and [...]

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During the COVID-19 pandemic, and every day, our Department of Pathology phlebotomists are on the front lines of patient care.

We often call our phlebotomists the face of the laboratory since they are often the first, if not the only, touchpoint to the department for patients. [...]

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I am standing in the Blood Bank at Michigan Medicine in Ann Arbor. I am looking at the refrigerator that contains only one day's supply of blood for the hospital. 

The hospital is full. There are patients who need blood and cannot wait. Some have leukemia. Some are bleeding. Some are infants born with heart disease who will die is they do not have surgery [...]

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Resources and guidance.

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Congratulations to Alex Taylor, MD, 3^rd year resident, for winning the first place Rodger Haggitt GI Pathology Award for his platform presentation at USCAP! 

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Sara Abbott, MD, took a winding road to becoming an assistant professor here at U-M. She actually has a master’s degree in education and spent two years guiding students grudgingly through high school biology. That’s when she realized that maybe this wasn’t the kind of teaching she was meant to do after all. [...]

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The event showcased experiemental pathology research.

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