The department of Pathology supports a robust research program including over 100 research faculty in over 40 laboratories, with 12 endowed professorships. Broad areas of research interests encompass basic, translational and clinical sciences, and utilize state of the art multi-disciplinary approaches investigating the pathobiology of human disease. Research programs in U-M Pathology encompass a wide range of topics in the areas of Aging, Cancer Biology, Development & DNA repair, Inflammation and Immunology, Mucosal Inflammation and Epithelial Pathobiology, Neurobiology/Pathology and Bioinformatics. Research strengths are further complemented by innovative clinical and translational research programs in Anatomic and Clinical Pathology.
Pathology research at U-M is supported by funding from the NIH, NSF, DOD, private foundations and pharmaceutical industry and ranks in the top ten nationally among Pathology Departments. Our recruitment efforts as well as recent funding successes have positioned U-M Pathology as a leading research destination in Pathology nationally.
Congratulations to Molecular and Cellular Pathology PhD student, Hung-An (Ana) Ting, in the laboratory of Dr. Nicholas Lukacs, whose work on “Notch Ligand Delta-like 4 Promotes Regulatory T Cell Identity in Pulmonary Viral Infection" is featured in the “In This Issue” section of the February 15, 2017 issue of The Journal of Immunology. The “In This Issue” highlights articles considered to be among the top 10% of articles published in the journal. Their work is on regulating lung pathology with the Notch pathway.
The laboratory of Dr. Celina Kleer, Harold A. Oberman Collegiate Professor, discovered that mammary-specific knock down of CCN6 results in mammary carcinomas with features of human metaplastic carcinomas. This model may lead to discovery of new diagnostic and therapeutic targets for this rare and aggressive form of triple negative breast cancer. The article appeared in Oncogene, on the November 7th 2016 issue, and can be found at www.nature.com
The laboratory of Dr. Tomasz Cierpicki has determined the structure of BMI1 protein in complex with PHC2 and characterized its role in regulation of the architecture and activity of the PRC1. The article "BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization" has been published in Nature Communications. Co-first authors are Felicia Gray, Hyo-Je Cho and Shirish Shukla, and this is a collaborative study with Dr. Grembecka and Dr. Lawlor from the Department of Pathology.