The Immunohistochemistry Laboratory

We offer over 300 immunohistochemical stains for diagnostic use. Among these are important predictive markers such as ER, PR, HER2, PD-L1 (22C3/SP142), and mismatch repair proteins (MSH2, MSH6, MLH1, PMS2). A number of chromogenic in-situ hybridization probes such as EBER, high- and low-risk HPV, and SARS-CoV-2 are also available. In addition, the Laboratory performs direct immunofluorescence on skin and kidney biopsies, and histochemistry on fresh/frozen skeletal muscles. Over 125,000 tests are performed annually on paraffin-embedded, frozen, and cytology specimens. Additional information on the immunohistochemical stains provided by the Laboratory can be found in the list below.


Click here for list of IHC Antibodies

Click here for list of ISH Probes


For clients outside of Michigan Medicine, please contact Michigan Medicine Laboratories (MLabs) for information on how to submit a test request.

For questions related to immunohistochemistry projects for research purposes, please contact the Research Histology Core.