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For information regarding upcoming seminars, contact Laura Labut, laszczem@med.umich.edu, (734) 763-0846.

Pathology Seminar Series are held on Thursdays from 4:00PM - 5:00PM in Pathology Seminar Room, 4234 Medical Science I , unless otherwise noted

 

2016-2017 Pathology Research Seminar Series

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May 25, 2017

Epigenetic remodeling in human hematopoietic stem cell aging

Emmalee Adelman

PhD candidate

Molecular & Cellular Pathology program

Mentor: Dr. Ken Figueroa

 
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May 18, 2017

Niche signaling and epigenetic regulation of stem cells

Linheng Li, PhD

Professor, Department of Pathology & Laboratory Medicine

University of Kansas School of Medicine

Host: Dr. Yali Dou

 
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May 11, 2017

Integrative genomic approaches to identify new cancer dependencies

Kimberly Stegmaier, MD

Associate Professor, Department of Pediatrics

Harvard Medical School

Host: Dr. Jolanta Grembecka

 
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May 4, 2017

Therapeutic resistance to BET bromodomain inhibition in prostate cancer

Carl Engelke

PhD candidate

Molecular & Cellular Pathology and MSTP programs

Mentor: Dr. Arul Chinnaiyan

 
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April 27, 2017

Environmental factors and regulation of the cytokine IL-22

Lauren Zenewicz, PhD

Assistant Professor, Department of Microbiology & Immunology

College of Medicine

The University of Oklahoma Health Sciences Center

Host: Dr. Gabriel Nuñez

 
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April 20, 2017

Epigentic and transcriptional regulation of cellular fate specification in the skin

Rui Yi, PhD

Associate Professor, Department of Molecular, Cellular & Developmental Biology

University of Colorado - Boulder

Host: Dr. Yali Dou

 
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April 13, 2017

Targeting the unfolded protein response in pancreatic neuroendocrine tumors - a highly secretory cancer

Scott Oakes, MD

Professor of Pathology

University of California, San Francisco

Host: Dr. David Lombard

 
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April 6, 2017  Will be rescheduled for Fall 2017

Ross Levine, MD

Physician Scientist, Leukemia Research

Memorial Sloan Kettering Cancer Center

Host: Dr. Jolanta Grembecka

 
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March 30, 2017*

Characterizing the role of Androgen Receptor regulated lncRNA ARlnc1 in prostate cancer

Yajia Zhang

PhD candidate

Molecular & Cellular Pathology program

Mentor: Dr. Arul Chinnaiyan

*Room changed to M3330 Med Sci I

 
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March 23, 2017

Targeting Auto-Inhibition to Inhibit “Undruggable” Transcription Factors

John Bushweller, PhD

Professor, Molecular Physiology, Biological Physics & Chemistry

University of Virginia

Host: Dr. Jolanta Grembecka

 
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March 16, 2017

Pathogenesis and Genomics of Ovarian Cancer: Converging on New Therapeutic Opportunities

Ronny Drapkin, MD, PhD

Principle Investigator, Department of Obstetrics & Gynecology

Director, Penn Ovarian Cancer Research Center

University of Pennsylvania

Host: Dr. David Lombard

 
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March 9, 2017

Sirtuins and Novel PTMs in Cancer

Hening Lin, PhD

Professor, Department of Chemistry & Chemical Biology

Cornell University

Host: Dr. David Lombard

 
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February 23, 2017

Fibroblast heterogeneity in the pancreatic microenvironment

Paloma Garcia

PhD candidate

Molecular & Cellular Pathology program

Mentors: Dr. Marina Pasca di Magliano & Dr. Gabriel Nuñez

 
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February 16, 2017

Evaluating mechanisms of PD-L1 regulation in head and neck cancer

Jacqueline Mann

PhD candidate

Molecular & Cellular Pathology program

Mentors: Dr. Chad Brenner & Dr. Alexey Nesvizhskii

 
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February 9, 2017

Chromatin and cell-type specific gene expression in mouse macrophages

Monique Floer, PhD

Assistant Professor, Biochemistry and Molecular Biology

Michigan State University

Host: Dr. Andrew Muntean

 
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February 2, 2017

TPRKB dependency in p53-deficient cancers

Kelly VanDenBerg

PhD candidate

Molecular & Cellular Pathology program

Mentor: Dr. Scott Tomlins

 
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January 26, 2017

Molecular profiling of unique cancer cohorts using targeted next-generation sequencing

Lorena Lazo de la Vega

PhD candidate

Molecular & Cellular Pathology program

Mentor: Dr. Scott Tomlins

 
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January 19, 2017*

Cytokine-mediated regulation of intestinal inflammation: Beauty and the Beast

Timothy Denning, PhD

Associate Professor, Center for Inflammation Immunity & Infection

Georgia State University, Institute for Biomedical Sciences

Host: Dr. Asma Nusrat

*Room changed to Danto Auditorium

 
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January 12, 2017*

New thinking on epithelial microbiota interactions

Andrew Neish, MD

Professor, Pathology & Laboratory Medicine

Emory University, School of Medicine

Host: Dr. Asma Nusrat

*Room changed to Danto Auditorium

 
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December 8, 2016

Targeting MCL-1 in malignancy

Joseph Opferman, PhD

Associate Member (Associate Professor)

Department of Cell & Molecular Biology

St. Jude Children's Research Hospital

Host: Dr. Zaneta Nikolovska-Coleska

 

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December 1, 2016

Malignant melanoma: Insights from genetic models and factors regulating tumor immune responses

Marcus Bosenberg, MD, PhD

Associate Professor

Dermatology and Pathology

Yale School of Medicine

Host: Dr. David Lombard

 

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November 17, 2016

IL-1 and TNF interplay in host protection against M.tuberculosis

Dmitry Shayakhmetov, PhD

Professor of Medicine

Division of Rheumatology

Emory University School of Medicine

Host: Dr. Gabriel Nuñez

 

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November 10, 2016

Targeting epigenetic mechanisms in leukemia

Kathrin Bernt, MD

Assistant Professor of Pediatrics

Department of Hematology/Oncology

Children's Hospital Colorado

University of Colorado - Denver

Host: Dr. Andrew Muntean

 

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November 3, 2016*

Molecular mechanisms underlying pandemics caused by group A Streptococcus, the flesh-eating pathogen

James Musser, MD, PhD

Chair, Department of Pathology and Genomic Medicine

Fondren Endowed Presidential Distinguished Chair

Director, Center for Molecular and Translational Human Infectious Diseases Research

Houston Methodist Hospital System and Houston Methodist Research Institute

Host: Dr. Asma Nusrat

*Room changed to Danto Auditorium

 

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October 27, 2016

Mechanotransduction, a driving force of idiopathic pulmonary fibrosis (IPF)?

Yong Zhou, PhD

Associate Professor in Medicine and of Molecular and Cellular Pathophysiology

Division of Pulmonary, Allergy & Critical Care Medicine

University of Alabama at Birmingham

Host: Dr. Sem Phan

 

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October 20, 2016

How telomeres repress the DNA damage response at chromosome ends

Sandy Chang, MD, PhD

Professor Laboratory Medicine, Pathology, Molecular Biophysics and Biochemistry

Associate Director, Molecular Diagnostics Laboratory

Yale School of Medicine

Host: Dr. David Lombard

 

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October 13, 2016

Cross-talk between oncogenic and immunogenic pathways and cancer immunotherapy

Weiping Zou, MD, PhD

Charles B. de Nancrede Professor of Surgery, Immunology and Biology

Department of Surgery

University of Michigan

 

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October 6, 2016

Tipping the balance: Modulating RAD51 to treat cancer and autoimmune disease

Kevin Mills, PhD

Chief Scientific Officer, Cyteir Therapeutics, Inc.

Associate Professor, Tufts Medical School

Host: Dr. David Lombard

 

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September 29, 2016

Type II mucosal immunity in C. difficile Infection

William Petri, MD, PhD

Wade Hampton Frost Professor of Epidemiology

Chief, Division of Infectious Diseases and International Health

University of Virginia School of Medicine

Host: Naohiro Inohara

 

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September 22, 2016

An ontogenic molecular switch controls human megakaryocyte differentiation

Adam Goldfarb, MD

Professor, Department of Pathology

University of Virginia School of Medicine

Host: Dr. Andrew Muntean

 

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September 15, 2016

Targeting metabolic vulnerabilities in cancer: new therapeutic approaches for EGFR-driven malignant gliomas

David Nathanson, PhD

Assistant Professor Molecular and Medical Pharmacology

University of California Los Angeles 

Host: Dr. Scott Tomlins

 


 2015-2016 Seminars

June 2, 2016

Lee J. Martin, PhD Taubman Visiting Scholar

Professor of Pathology and Neuroscience

Co-Investigator, Neuropathology Core

Johns Hopkins University

 *Note room change - CVC Danto Auditorium


May 26, 2016

Peter C. Lucas, MD, PhD Associate Professor of Pathology and Pediatrics

Divisions of Molecular Genomic Pathology and Experimental Pathology

Member, Vascular Medicine Institute

University of Pittsburgh


May 19, 2016

Metabolic heterogeneity in molecular subtypes of diffuse large B cell lymphoma

Nika N. Danial, PhD Associate Professor of Cell Biology

Harvard Medical School

Dana-Farber Cancer Institute


May 12, 2016 

Epithelial-mesenchymal plasticity in carcinoma metastasis

Jing Yang, PhD Associate Professor of Pharmacology and Pediatrics

University of California, San Diego

School of Medicine


May 5, 2016

Containing flagellin: a priority for host-microbiota detente

Charles O. Elson III, MD Professor and Director, Division of Gastroenterology & Hepatology

Basil I. Hirschowitz Chair in Gastroenterology

University of Alabama, Birmingham

School of Medicine

*Note room change - CVC Danto Auditorium


April 28, 2016

The role of gut microbiota-induced IgG antibodies in host defense

Melody Zeng, PhD Research Investigator

Department of Pathology

University of Michigan


April 21, 2016

Structural elucidation of resolvins and novel resolution phase mediators in infectious inflammation & tissue regeneration

Charles Serhan, PhD

Center for Experimental Therapeutics and Reperfusion Injury

Brigham and Women's Hospital

The Simon Gelman Professor of Anaesthesia (Biochemistry & Molecular Pharmacology)

Harvard Medical School and Prof. HS Dental Medicine

*Note room change - CVC Danto Auditorium


April 14, 2016

Desmoglein-2 intracellular cleavage and intestinal epithelial barrier compromise

Mark Yulis Doctoral Candidate (Mentor: Asma Nusrat, MD, University of Michigan, Department of Pathology)

Biochemistry, Cell and Developmental Biology Program

Emory University


April 7, 2016

Characterization of a novel mucosal chemokine and its receptor

Albert Zlotnik, PhD Professor of Physiology and Biophysics

Associate Director, Institute for Immunology

University of California, Irvin


March 31, 2016

The blood-brain barrier in multiple sclerosis - two tales of breakdown and repair

Dritan Agalliu, PhD Assistant Professor of Pathology and Cell Biology

Columbia University

College of Physicians & Surgeons


March 24, 2016

BioArtificial Hydrogels for Regenerative Medicine

Andrés J. Garcia, PhD, FBSE Rae S. and Frank H. Neely Chair and Regents’ Professor

Woodruff School of Mechanical Engineering

Petit Institute for Bioengineering and Bioscience

Georgia Institute of Technology

*Note room change - CVC Danto Auditorium


March 17, 2016

Structure & Function of the Corepressor MINT/SHARP: a Negative Regulator of Notch Signaling

Rhett Kovall, PhD Associate Professor of Molecular Genetics

University of Cincinnati

College of Medicine


March 10, 2016

Inflammatory cell death pathways in control of bacterial infection

Igor Brodsky, PhD Assistant Professor

Department of Pathobiology

University of Pennsylvania

School of Veterinary Medicine


March 3, 2016

No seminar due to spring break


February 25, 2016

The role of AR-regulated long non-coding RNA in prostate cancer

Yajia Zhang Doctoral Candidate (Mentor: Arul Chinnaiyan, MD, PhD)

Molecular and Cellular Pathology Program

University of Michigan Medical School


February 18, 2016

Targeting EWS-fusion driven Ewing sarcoma by BET bromodomain inhibitors

Carl Engelke Doctoral Candidate (Mentor: Arul Chinnaiyan, MD, PhD)

Molecular and Cellular Pathology Program and Medical Scientist Training Program

University of Michigan Medical School


February 11, 2016

How senecent cells contribute to aging and disease

Jan van Deursen, PhD Director, Gene Knockout Core Facility

Professor of Biochemistry/Molecular Biology

Professor of Pediatrics

Mayo Clinic


February 4, 2016

Mitochondria and Aging

Toren Finkel, MD, PhD Chief, Center for Molecular Medicine

National Heart, Lung and Blood Institute

National Institutes of Health


January 28, 2016

The role of Cdc73 in acute myeloid leukemia

James Ropa Doctoral Candidate (Mentor: Andrew Muntean, PhD)

Molecular and Cellular Pathology Program

University of Michigan Medical School


January 21, 2016

Development of Chemical and Genetic Tools to Understand and Target MLL-rearranged Leukemia Protein-Protein Interactions

Sierrah Grigsby Doctoral Candidate (Mentor: Zaneta Nikolovska-Coleska PhD)

Molecular and Cellular Pathology Program

University of Michigan Medical School


January 14, 2016

Tumorigenicity of Ewing sarcoma is critically dependent on the trithorax proteins MLL and menin

Laurie Svoboda, PhD Research Fellow (Lawlor Laboratory)

Pediatrics and Communicable Diseases

University of Michigan Medical School

 

9/10/15 - No seminar, new student orientation only

 

9/17/15 - Mitochondrial stress signaling in aging and immunity

Gerald Shadel, PhD Professor of Pathology and Genetics

Director, Pathology Research

Yale University

 

9/24/15 - The role of glycosylation in mediating neutrophil migration across intestinal epithelium

Jennifer Brazil, PhD Research Investigator

Department of Pathology

University of Michigan

 

10/1/15 - Tripping treatment resistance in head and neck cancer

Nisha D'Silva, BDS, MSD, PhD Donald A. Kerr Endowed Collegiate Professor of Oral Pathology

Professor of Dentistry, Department of Oral Medicine, Pathology and Oncology

Associate Professor of Pathology

University of Michigan

 

10/8/15 - Androgen receptor-mediated transcription program and its regulation in prostate cancer *co-hosted with Biochemistry

Jindan Yu, MD, PhD Associate Professor

Division of Hematology/Oncology

Northwestern University Feinberg School of Medicine

 

10/15/15 - Identification of pathogenicity-associated genes in Klebsiella pneumoniae clinical isolates

Rebekah Martin Doctoral Candidate (Mentor: Michael Bachman, MD, PhD)

Molecular and Cellular Pathology Program

University of Michigan Medical School

 

10/22/15 - Notch ligand Delta-like ligand 4 maintained Foxp3+ regulatory T cells by an epigenetic mechanism

Hung-An Ting Doctoral Candidate (Mentor: Nicholas Lukacs, PhD)

Molecular and Cellular Pathology Program

University of Michigan Medical School

 

10/29/15 - Innate immune signaling in malignant hematopoiesis

Daniel Starczynowski, PhD Associate Professor

UC Department of Pediatrics

Cincinnati Children's Hospital

 

11/5/15 - No seminar due to 14th Annual Pathology Research Symposium

 

11/12/15 - Mitochondrial stress response in long-lived mice

Ulas Ozkurede Doctoral Candidate (Mentor: Richard Miller, MD, PhD)

Molecular and Cellular Pathology Program

University of Michigan Medical School

 

11/19/15 - Phosphorylation of EZH2 in triple-negative breast cancer

Talha Anwar Doctoral Candidate (Mentor: Celina Kleer, MD)

Molecular and Cellular Pathology Program and Medical Scientist Training Program

University of Michigan Medical School

 

11/26/15 - No seminar due to holiday

 

12/10/15 - Cancer-centric view on chimeric RNAs

Hui Li, PhD Associate Professor of Pathology

University of Virginia

School of Medicine

*Note change of date

 

12/17/15 - Insights to treatment resistant prostate cancer

Colin Collins, PhD Professor, Department of Urologic Sciences

University of British Columbia

Sr. Research Scientist & Director, Laboratory for Advanced Genome Analysis

Vancouver Prostate Centre

*Note room change - 5330 Med Sci I

 

12/24/15 - No seminar due to holiday

 

12/31/15 - No seminar due to holiday