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"A Correct Diagnosis Can Be Life-Changing": Dr. Rohit Mehra
Dr. Mehra discusses his career path and how he arrived at Michigan Medicine in our latest Careers in Pathology video.
Stressed Cellular Protein HOPS Into Action
Research team discovered that proteins with the capacity to multimerize quickly responded to osmotic changes (dehydration) caused by high saline or sugar concentrations, condensing into aggregates resembling processing bodies (P-bodies). The reaction, known as hyperosmotic phase separation, or HOPS, takes only a few seconds and is reversible within less than 2 minutes [...]
Research from Dr. Udager Published in European Urology
A new publication, generated by Department of Pathology faculty members Drs. Aaron Udager and Scott Tomlins was successfully published in European Urology. The research highlights a longitudinal cohort study centered around the serial molecular profiling of low-grade prostate cancer in order to better assess tumor upgrading [...]
Prostate Cancer Regulator Plays Role in COVID-19, Providing a Promising Treatment Lead
Clinical trials underway are testing whether drugs that target the androgen receptor – successful in controlling prostate cancer – could also work against the coronavirus. wo proteins, ACE2 and TMPRSS2, help the coronavirus gain entry and replicate within cells. TMPRSS2 is well-known to Arul Chinnaiyan, MD, PhD. His lab discovered that TMPRSS2 fuses with the ETS gene to drive more than half of all prostate cancers [...]
Research Regarding Microcystic Adnexal Carcinomas Published
The research was just published in Modern Pathology and highlights the importance of next-generation sequencing within oncogenic roles for P53 and JAK/STAT signaling in microcystic adnexal carcinomas.
U-M Researchers Home in on Key Player in Pancreatic Cancer Development
The protein Argonaute 2 was found to be critical to the progression from benign lesions into pancreatic cancer, suggesting a therapeutic opportunity.
Research Regarding Invasive Squamous Cell Carcinoma Published
The research, which focuses on invasive squamous cell carcinomas and the precursor lesions that demonstrate concordic genomic complexity in driver genes, was just published in Modern Pathology.
Research about Renal Cell Carcinoma in Young Adults Published
The research was just published in Histopathology and features prominent contributions from our faculty.
Arul Chinnaiyan, MD, PhD, elected to the National Academy of Science
Congratulations to Arul M. Chinnaiyan, MD, PhD, on his election to the National Academy of Science! Chinnaiyan is an investigator, Howard Hughes Medical Institute; and S.P. Hicks Endowed Professor of Pathology, American Cancer Society Research Professor, and director, Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor [...]
Marcin Cieslik Receives Award from Bristol-Myers Squibb
Marcin Cieslik, Assistant Professor of Pathology and Computational Medicine and Bioinformatics and member of the Michigan Center for Translational Pathology (MCTP), received an award from Bristol-Myers Squibb (BMS) for the project entitled, “Identification of novel therapeutic vulnerabilities across immunophenotypes of refractory and metastatic tumors.” This award provides two years of funding.
Engaging Our Future
Department faculty outreach to high school students to educate about careers in medicine and research.
Faculty and Trainees Work to Understand Therapy-Resistant Malignancies
Two Michigan Medicine Fellows, Caroline Simon, MD, and Stephanie Skala, MD, (who recently joined the Department of Pathology as faculty), joined colleagues from the Michigan Center for Translational Pathology, in a research study published in Diagnostic Pathology dated October 21, 2019 [...]
U-M Compounds Show Promise in a Lab Model of Advanced Prostate Cancer
A new study finds that U-M-designed compounds led to significantly smaller, slower-growing tumors.
Witnessing the dance of RNAs around droplets of cellular degradation machinery
If a picture's worth a thousand words, a video is perhaps worth much more.
Medicine, Humility, Respect, and Beyond
Rohit Mehra, MD—faculty perspective on the need to understand why a patient’s cancer would not respond to treatment.
Team Led by Dr. Rohit Mehra discovers New Diagnostic Biomarker for Kidney Cancer
A recent collaborative study out of the Michigan Center for Translational Pathology (MCTP) has led to new insight into kidney cancer. The resulting paper, VSTM2A Overexpression is a Sensitive and Specific Biomarker for [...]
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