Activity of the polycomb repressive complex 1 is essential for the development and maintenance of leukemic cells; disrupting it presents a new potential therapeutic approach. Leukemia stem cells are rare cells that can renew themselves while continuing to generate malignant cells known as leukemic blasts. These cells are difficult to eradicate using chemotherapy drugs and frequently lead to recurrence of leukemia [...]
Research by Drs. Alexander Taylor and Stephanie Skala seek to understand why tumors masquerade as forms of type-2 papillary of renal cell carcinoma. The study was just published in Urologic Oncology's ScienceDirect [...]
Research from the Department of Pathology was just published in the Archives of Pathology and Laboratory Medicine. Learn more about this publication, which highlights GI samples from COVID-19 patients, led by Dr. Maria Westerhoff [...]
A research effort by Drs. Jolanta Grembecka and Tomasz Cierpicki was just published in Nature Communications. Learn more about the protein made by the ASH1L gene, which plays a key role in the development of acute leukemia, along with other diseases [...]
Research from the Department's Lombard Lab was just published in the Journal of Clinical Investigation. The study, which focuses on how the deacylase SIRT5 compound supports melanoma viability by influencing chromatin dynamics, was led by Dr. Lombard [...]
Learn more about pathologists' attitudes toward patient interactions in this new publication, led by Dr. Cathryn Lapedis.
A new publication from the Department of Pathology, led by Dr. Kathleen Cho, was just published in the American Association for Cancer Research's flagship journal. highlights how altering the microbiome within a mouse model of oviductal high-grade serious carcinoma can inhibit tumorigeneis [...]
The Department of Pathology was well represented at the 110th Annual Meeting of the United States and Canadian Academy of Pathology (USCAP), held March 13-18, 2021. This year's event was reconstructed into a fully virtual format in response to the COVID-19 pandemic, with participants able to tune in and contribute from all over the world. Several of our faculty and trainees were featured at this year's conference. Let's take a moment to recap some key highlights from #USCAP2021.
Research by Drs. Ann Laszczyk and the Department of Pathology's Dr. Gregory Dressler was just published in the Journal of the American Society of Nephrology. The study focuses on PAX2 proteins and their effects on kidney function and development.
Research team discovered that proteins with the capacity to multimerize quickly responded to osmotic changes (dehydration) caused by high saline or sugar concentrations, condensing into aggregates resembling processing bodies (P-bodies). The reaction, known as hyperosmotic phase separation, or HOPS, takes only a few seconds and is reversible within less than 2 minutes [...]
A series of sophisticated processes are required in the development of innate lymphoid cells (ILC) for them to reach maturity. The Kim laboratory discovered that basic leucine zipper ATF-like transcription factor (Batf) regulates the production of ILC progenitors in the bone marrow as well as the maintenance of ILCs in the periphery. These cells are strategically distributed in peripheral tissues to provide important innate immunity to fight pathogens such as pathogenic viruses and bacteria.
A new publication, generated by Department of Pathology faculty members Drs. Aaron Udager and Scott Tomlins was successfully published in European Urology. The research highlights a longitudinal cohort study centered around the serial molecular profiling of low-grade prostate cancer in order to better assess tumor upgrading [...]
A new study by the University of Michigan's Rogel Cancer Center analyzed patients with cancer and the factors that cause the cancer to spread to the liver, leading to worse outcomes.
Clinical trials underway are testing whether drugs that target the androgen receptor – successful in controlling prostate cancer – could also work against the coronavirus. wo proteins, ACE2 and TMPRSS2, help the coronavirus gain entry and replicate within cells. TMPRSS2 is well-known to Arul Chinnaiyan, MD, PhD. His lab discovered that TMPRSS2 fuses with the ETS gene to drive more than half of all prostate cancers [...]
A new study led by Drs. Jolanta Grembecka and Tomasz Cierpicki of the Department of Pathology was just published in Blood's American Society of Hematology. The research focuses on combinatorial treatment with menin and FLT3 and how inhibitors induce complete remission in acute myeloid leukemia (AML) with activating FLT3 mutations [...]
New research by the Department of Pathology was recently published in Modern Pathology. The study, led by Drs. Aaron Udager, Noah Brown, Bryan Betz, Jonathan McHugh and Scott Tomlins, focuses on how TP53 mutations and CDKN2A mutations and deletions are highly recurrent molecular alterations within malignant progression of sinonasal papilomas [...]
Congratulations to Dr. Celina Kleer who was awarded the American Society for Investigative Pathology (ASIP)'s 2020 Outstanding Investigator Award. Dr. Kleer receives the award for her demonstrated excellence in research in experimental pathology [...]
Research by the Department of Pathology's Drs. Richard Miller and Joseph Endicott was just published in the Journal of Cell Biology. The study focuses on the inhibition of class I PI3K and how it enhances chaperone-mediated autophagy (CMA) [...]
12:00 pm EST
Join #UMichPath and the University of Pennsylvania's Perelman School of Medicine for a virtual event with department faculty Dr. Gabriel Nuñez, who will be hosting a discussion related to host-microbiota interactions in modern health and disease.
Experts from the Department of Pathology's Phlebotomy Team were featured on Michigan Medicine's "The Wrap" podcast. The podcast focuses on the department's Poke Plan Program at C.S. Mott Children's Hospital, an initiative that helps to alleviate pain and fear among children during the blood draw process [...]
Diarrhea can be the unfortunate but short-lived side effect of bad takeout food, yet it is also a leading cause of death in children under five globally. Scientists continue to investigate how illness-causing bacteria gain a foothold within the digestive tract when they are usually held in check by the protective bacteria collectively known as the gut microbiome [...]
10:00 am EST
Join us for a virtual event featuring the Department of Pathology's Dr. Celina Kleer, who will host a discussion related to her experiences in understanding breast cancer and her journey as a physician-scientist.
11:30 am EST
Join us for a virtual event featuring the Department of Pathology's Dr. Arul Chinnaiyan, who will give the 2020 American Society for Investigative Pathology (ASIP)'s Rous-Whipple Award Lecture.
New research from the Department of Pathology and Dr. Alexandra Hristov was just published in the Journal of Cutaneous Pathology. The study focuses on the kappa and lambda immunohistochemistry in situ hybridization of atypical cutaneous lymphoid infiltrates.
Structural biology techniques helped researchers target the nuclear receptor-binding SET domain family, whose malfunction is associated with several types of cancer.
New research related to H3K27M-mutant diffuse midline glioma with extensive intratumoral microthrombi in young adults with COVID-19 from the Department of Pathology was just published in Acta Neurologica. [...]
The protein Argonaute 2 was found to be critical to the progression from benign lesions into pancreatic cancer, suggesting a therapeutic opportunity.
The research, which focuses on invasive squamous cell carcinomas and the precursor lesions that demonstrate concordic genomic complexity in driver genes, was just published in Modern Pathology.
A Phase I clinical trial, using a structurally related analog of the compound, is currently enrolling patients.
Modern Pathology recently published a multi-institutional study led by pathology faculty Dr. Rohit Mehra; other participating centers included The Cleveland Clinic, Emory School of Medicine and Memorial Sloan Kettering Cancer Center. Third year Pathology resident at Michigan Medicine, Alex Taylor, MD, was the first author with other major contributions by Drs. Noah Brown and May Chan. [...]
Chan Chung, PhD, received two grants in funding from the ChadTough Foundation and Defeat DIPG foundation ($150,000) and the Robert Connor Dawes CERN Pediatric Fellowship ($100,000). [...]
All faculty who serve as the Principal Investigator or one of the key personnel on an NIH award or pending proposal are required to review their new guidance and address the two parts below, as appropriate, by January 20, 2020 [...]
The National Cancer Institute’s (NCI) Predoctoral to Postdoctoral Fellow Transition (F99/K00) Award supports outstanding PhD and other Research Doctoral candidates who complete their dissertation research training (F99 phase) and transition in a timely manner to mentored, cancer-focused postdoctoral career development research positions (K00 phase). [...]
Carrie-Anne Malinczak, PhD successfully defended her thesis entitled “Long-Term Immune System Alterations Following Early-Life RSV Infection” on October 21, 2019. Respiratory syncytial virus (RSV), a ubiquitous human pathogen, infects nearly all children by age two. Severe RSV bronchiolitis in infancy is strongly correlated with the development of recurrent wheezing later in childhood [...]
Surinder Kumar, Ph.D., has received The Pablove Foundation Childhood Cancer Research Grant for his proposal entitled “The sirtuin SIRT5 as a novel therapeutic target for Ewing’s Sarcoma” [...]
In collaboration with Drs. Luke Nayak and Arjun Sondhi, Dr. Maria Westerhoff published a report in Gastroenterology titled, "A Rare Complication of a Rare Disease" documents a case of erythropoietic protoporphyria, a rare condition that can affect the liver [...]
Congratulations to Jolanta Gembecka, PhD, who is one of fourteen in the inaugural class of Rogel Scholars! As part of the commitment from Richard and Susan Rogel, researchers will have the opportunity and freedom to pursue new directions in their work. Dr. Grembecka's research focus is developing [...]
Researchers identify a lncRNA that provides insight into a key driver of prostate cancer — and a potential target for future therapy.