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Targeting a metabolite as a therapy for childhood ependymomas

February 4, 2026 / Cancer Research

A new study published in Nature by Dr. Sriram Venneti’s laboratory at the University of Michigan’s Department of Pathology and the Chad Carr Pediatric Brain Tumor Center has identified a surprising driver of ependymoma growth: a molecule called itaconate. The discovery opens the door to new therapeutic strategies for this aggressive childhood cancer.

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