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TRIM63 - What is it? (Hint: Not a weight-loss product)
Dr. Xiao-Ming (Mindy) Wang and colleagues from the Michigan Center for Translational Pathology and Department of Pathology published a groundbreaking finding from an inter-institutional study regarding TRIM63 in Modern Pathology [...]
2020 Annual Report Now Available
The Department of Pathology's 2020 Annual Report is now available online. In the report, you will read about the department’s tripartite mission of research, education, and patient care, and learn about the goals of the department’s Strategic Council [...]
Research Published in Urologic Oncology's ScienceDirect
Research by Drs. Alexander Taylor and Stephanie Skala seek to understand why tumors masquerade as forms of type-2 papillary of renal cell carcinoma. The study was just published in Urologic Oncology's ScienceDirect [...]
Coronavirus (COVID-19) Research Published in Archives of Pathology and Laboratory Medicine
Research from the Department of Pathology was just published in the Archives of Pathology and Laboratory Medicine. Learn more about this publication, which highlights GI samples from COVID-19 patients, led by Dr. Maria Westerhoff [...]
Researchers Develop First-in-Class Inhibitors Against Key Leukemia Protein
A research effort by Drs. Jolanta Grembecka and Tomasz Cierpicki was just published in Nature Communications. Learn more about the protein made by the ASH1L gene, which plays a key role in the development of acute leukemia, along with other diseases [...]
Research from Lombard Lab Published in Journal of Clinical Investigation
Research from the Department's Lombard Lab was just published in the Journal of Clinical Investigation. The study, which focuses on how the deacylase SIRT5 compound supports melanoma viability by influencing chromatin dynamics, was led by Dr. Lombard [...]
Broadening the Scope: A Qualitative Study of Pathologists’ Attitudes Toward Patient-Pathologist Interactions
Learn more about pathologists' attitudes toward patient interactions in this new publication, led by Dr. Cathryn Lapedis.
Passing the Test: Pathology Department Teams Help Carry Michigan Medicine Through Pandemic
The department has navigated an unprecedented workload over the past year and continues to increase. Hear from experts Christine Kizer, Dr. Michael Bachman, Jennifer Bergendahl, and more, as they discuss how efforts have helped Michigan Medicine stay afloat during the COVID-19 pandemic [...]
Research by Dr. Cho Published in AACR's "Cancer Research"
A new publication from the Department of Pathology, led by Dr. Kathleen Cho, was just published in the American Association for Cancer Research's flagship journal. highlights how altering the microbiome within a mouse model of oviductal high-grade serious carcinoma can inhibit tumorigeneis [...]
Biomarker Could Help Identify Difficult-to-Diagnose Kidney Cancer Subtype
MiTF renal cell carcinoma can masquerade as other subtypes and may not respond as well to front-line therapies.
Two Proteins Critical for Kidney Function
Research by Drs. Ann Laszczyk and the Department of Pathology's Dr. Gregory Dressler was just published in the Journal of the American Society of Nephrology. The study focuses on PAX2 proteins and their effects on kidney function and development.
Role of BATF in the Development of Innate Lymphoid Cells Elucidated
A series of sophisticated processes are required in the development of innate lymphoid cells (ILC) for them to reach maturity. The Kim laboratory discovered that basic leucine zipper ATF-like transcription factor (Batf) regulates the production of ILC progenitors in the bone marrow as well as the maintenance of ILCs in the periphery. These cells are strategically distributed in peripheral tissues to provide important innate immunity to fight pathogens such as pathogenic viruses and bacteria.
Prognostic Subgroups of Merkel Cell Carcinoma Defined
A collaboration between the Department of Pathology and the Department of Dermatology examined biomarkers of outcomes in 346 cases of Merkel cell carcinoma (MCC), an aggressive type of skin cancer. The study was published in the recent edition of Clinical Cancer Research [...]
Research from Dr. Udager Published in European Urology
A new publication, generated by Department of Pathology faculty members Drs. Aaron Udager and Scott Tomlins was successfully published in European Urology. The research highlights a longitudinal cohort study centered around the serial molecular profiling of low-grade prostate cancer in order to better assess tumor upgrading [...]
Prostate Cancer Regulator Plays Role in COVID-19, Providing a Promising Treatment Lead
Clinical trials underway are testing whether drugs that target the androgen receptor – successful in controlling prostate cancer – could also work against the coronavirus. wo proteins, ACE2 and TMPRSS2, help the coronavirus gain entry and replicate within cells. TMPRSS2 is well-known to Arul Chinnaiyan, MD, PhD. His lab discovered that TMPRSS2 fuses with the ETS gene to drive more than half of all prostate cancers [...]
Research Led by Drs. Cierpicki and Grembecka Published in "Blood"
A new study led by Drs. Jolanta Grembecka and Tomasz Cierpicki of the Department of Pathology was just published in Blood's American Society of Hematology. The research focuses on combinatorial treatment with menin and FLT3 and how inhibitors induce complete remission in acute myeloid leukemia (AML) with activating FLT3 mutations [...]
Research Led by Dr. Udager Published in Modern Pathology
New research by the Department of Pathology was recently published in Modern Pathology. The study, led by Drs. Aaron Udager, Noah Brown, Bryan Betz, Jonathan McHugh and Scott Tomlins, focuses on how TP53 mutations and CDKN2A mutations and deletions are highly recurrent molecular alterations within malignant progression of sinonasal papilomas [...]
Study Regarding Inhibition of Class I PI3K Published in Journal of Cell Biology
Research by the Department of Pathology's Drs. Richard Miller and Joseph Endicott was just published in the Journal of Cell Biology. The study focuses on the inhibition of class I PI3K and how it enhances chaperone-mediated autophagy (CMA) [...]
Research By Dr. Hristov Published in Journal of Cutaneous Pathology
New research from the Department of Pathology and Dr. Alexandra Hristov was just published in the Journal of Cutaneous Pathology. The study focuses on the kappa and lambda immunohistochemistry in situ hybridization of atypical cutaneous lymphoid infiltrates.
Utilizing Machine Learning in Pathology
In a recently published Nature Reviews-Nephrology review article, “Digital pathology and computational image analysis in nephropathology,” Dr. Ulysses G. J. Balis discussed how the emergence of digital pathology — an image-based environment for the acquisition, management, and interpretation of pathology information supported by computational techniques for data extraction and analysis — is changing the pathology ecosystem [...]
Study of SARS-CoV-2 reveals new disease surveillance method
In a broadly collaborative effort, Pathology faculty Drs. Carl Schmidt, Jeffrey Myers, Kristine Konopka, Paul Lephart, and Teresa Nguyen joined Michigan Medicine faculty from the departments of Epidemiology, Internal Medicine, Microbiology and Immunology, Mathematics and Complex Systems, and the School of Public Health in a study published in Clinical Infectious Diseases entitled “SARS-CoV-2 surveillance in decedents in a large, urban medical examiner’s office.”
Research Surrounding H3K27M-mutant diffuse midline glioma in COVID-19 Published
New research related to H3K27M-mutant diffuse midline glioma with extensive intratumoral microthrombi in young adults with COVID-19 from the Department of Pathology was just published in Acta Neurologica. [...]
Research Surrounding miR-181a Published
Research from Dr. Analisa Difeo was just published in Nature Communications. The study focuses on miR-181a and how it initiates and perpetuates oncogenic transformation through the regulation of innate immune signaling [...]
Forensic Research Regarding COVID-19 Published
The publication takes an in-depth examination of diffuse alveolar damage (DAD) caused by COVID-19 and how it is morphologically indistinguishable from other causes of DAD.
Frontline Workers in the Backrooms of COVID-19: Caring for the Living and the Dead
Dr. Jeffrey Myers discusses the importance of frontline workers and their caring of patients - alive or deceased - during the COVID-19 pandemic.
Research Regarding Invasive Squamous Cell Carcinoma Published
The research, which focuses on invasive squamous cell carcinomas and the precursor lesions that demonstrate concordic genomic complexity in driver genes, was just published in Modern Pathology.
Research about Renal Cell Carcinoma in Young Adults Published
The research was just published in Histopathology and features prominent contributions from our faculty.
2019 Annual Report Now Available
The Department of Pathology 2019 Annual Report is now available online. Our department continues to show outstanding performance and growth and the past year was another example of why our department is one of the best in the world.
In the report, you will read about [...]
New Research Published in Modern Pathology
The study pertains to the molecular characterization of uterine and ovarian tumors and their relationships to epithelial and germ cell features by somatic derivation.
New Research Published in Journal of Lower Genital Tract Disease
The study sheds light on alternative methods used for measuring size and depth of vulvar squamous cell carcinoma.
Study from Lieberman Lab Published in Acta Neuropathologica
A new study from the Andrew Lieberman Laboratory’s Samir Nath, et al, has discovered that MEF2 impairment underlies skeletal muscle atrophy in polyglutamine disease.
Kennedy’s Disease, also known as Spinal and Bulbar Muscular Atrophy (SBMA), is a disease caused by an inherited gene mutation that results in muscle and brain cell dysfunction. Patients progressively lose muscle mass until they are unable to walk without assistance. Ultimately [...]
Diagnostic Biomarkers Uncovered for Rare Kidney Cancer
Researchers have uncovered the gene signature for ChRCC.
New Study Finds Inhibition of Uric Acid or IL-1β Ameliorates Respiratory Syncytial Virus Immunopathology and Development of Asthma
The study details research surrounding Respiratory Syncytial Virus (RSV) among infants.
New Study Finds Resolvin E1 is a Pro-repair Molecule that Promotes Intestinal Epithelial Wound Healing
Resolvin E1 (RvE1), a lipid derived from Omega-3 fatty acids, is a pro-repair molecule that promotes healing of intestinal wounds according to a recent study published in PNAS as a collaborative project between The Department of Pathology at the University of Michigan Medical School and [...]
Results of Michigan-Led Study Published in Modern Pathology
Modern Pathology recently published a multi-institutional study led by pathology faculty Dr. Rohit Mehra; other participating centers included The Cleveland Clinic, Emory School of Medicine and Memorial Sloan Kettering Cancer Center. Third year Pathology resident at Michigan Medicine, Alex Taylor, MD, was the first author with other major contributions by Drs. Noah Brown and May Chan. [...]
Results from the Andrew P. Lieberman Lab are Published
Mark Schultz, PhD, and Andrew Lieberman MD, PhD, have published “Synthetic high-density lipoprotein nanoparticles for the treatment of Niemann–Pick diseases” in BMC Medicine. [...]
Engaging Our Future
Department faculty outreach to high school students to educate about careers in medicine and research.
Faculty and Trainees Work to Understand Therapy-Resistant Malignancies
Two Michigan Medicine Fellows, Caroline Simon, MD, and Stephanie Skala, MD, (who recently joined the Department of Pathology as faculty), joined colleagues from the Michigan Center for Translational Pathology, in a research study published in Diagnostic Pathology dated October 21, 2019 [...]
PCR-based TERT Promoter Assays Aid in Bladder Cancer Diagnosis
Our department's clinical resident Alex Taylor, MD, joined postdoctoral fellow Rahul Mannon, PhD, and other researchers from the Department of Pathology and the Michigan Center for Translational Pathology, who found that patients with a long-standing history of prostate cancer and other prostatic issues can find difficulty [...]
A Fundamental Passion
Bryan Betz, PhD, was inspired by his late wife, Sharon, to pursue a career in clinical diagnostics.
A Blank Canvas
A look at the artists behind the artwork hung in the newly renovated facility.
Study led by McMullen and Chan published in the American Journal of Surgical Pathology
A study by Drs. Emily McMullen, Paul Harms, Lori Lowe, Doug Fullen, and May Chan is published in the September issue of the American Journal of Surgical Pathology (AJSP). Calciphylaxis is a dermatologic emergency where an accurate and timely diagnosis is crucial but [...]
Dr. Maria Westerhoff Publishes in Gastroenterology
In collaboration with Drs. Luke Nayak and Arjun Sondhi, Dr. Maria Westerhoff published a report in Gastroenterology titled, "A Rare Complication of a Rare Disease" documents a case of erythropoietic protoporphyria, a rare condition that can affect the liver [...]
Drs. Westerhoff and Greenson Co-write Chapter in Histology Text Book
The Fifth Edition of Histology for Pathologists has just been published by Wolters Kluwer and Maria Westerhoff, MD, and Joel Greenson, MD, co-wrote the chapter on colon histology. The newest edition of this award-winning book is a comprehensive collection of normal histology written by anatomic pathologists for anatomic pathologists. The book is designed to [...]
Circular RNA Holds Promise as Cancer Biomarker
Unique structure of circRNA makes it an ideal candidate for biomarkers – and it can be detected in blood or urine.
Building Better Bridges
A new U-M initiative aims to improve the patient experience by forging connections between pathologists and the people they serve.
Dr. Khatri et al. Published in the Journal of the American Academy of Dermatology
Dr. Sameer Khatri along with the Department of Pathology's Drs. Min Wang, Paul Harms, Douglas Fullen, Aleodor Andea, and May Chan, in collaboration with other U-M [...]
Work by Peter A. Ward, MD, featured in Nature Immunology
The Review Article, Innate immune responses to trauma, was released today in Nature Immunology. This work, by Markus Huber-Lang of the University Hospital of Ulm, Institute of Clinical and Experimental Trauma-Immunology in Ulm Germany, John D. Lambris of the University of Pennsylvania School of Medicine, Department of Pathology [...]
Modern Pathology Cover Features Research by Mehra, Skala, and Team
Clinical FISH Assays for TFE3 and TFEB Help Characterize Renal Cell Carcinoma.
Immunohistochemistry Used to Investigate Genetic Link
The work entitled The Utility of SDHB and FH Immunohistochemistry in Patients Evaluated for Hereditary Paraganglioma-Pheochromocytoma Syndromes by Aaron M. Udager, MD, PhD, and colleagues in the Department of Pathology was published in Human Pathology on [...]
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