Clinical trials underway are testing whether drugs that target the androgen receptor – successful in controlling prostate cancer – could also work against the coronavirus. wo proteins, ACE2 and TMPRSS2, help the coronavirus gain entry and replicate within cells. TMPRSS2 is well-known to Arul Chinnaiyan, MD, PhD. His lab discovered that TMPRSS2 fuses with the ETS gene to drive more than half of all prostate cancers [...]

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A new study led by Drs. Jolanta Grembecka and Tomasz Cierpicki of the Department of Pathology was just published in Blood's American Society of Hematology. The research focuses on combinatorial treatment with menin and FLT3 and how inhibitors induce complete remission in acute myeloid leukemia (AML) with activating FLT3 mutations [...]

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New research by the Department of Pathology was recently published in Modern Pathology. The study, led by Drs. Aaron Udager, Noah Brown, Bryan Betz, Jonathan McHugh and Scott Tomlins, focuses on how TP53 mutations and CDKN2A mutations and deletions are highly recurrent molecular alterations within malignant progression of sinonasal papilomas [...]

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Research by the Department of Pathology's Drs. Richard Miller and Joseph Endicott was just published in the Journal of Cell Biology. The study focuses on the inhibition of class I PI3K and how it enhances chaperone-mediated autophagy (CMA) [...]

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New research from the Department of Pathology and Dr. Alexandra Hristov was just published in the Journal of Cutaneous Pathology. The study focuses on the kappa and lambda immunohistochemistry in situ hybridization of atypical cutaneous lymphoid infiltrates. 

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In a recently published Nature Reviews-Nephrology review article, “Digital pathology and computational image analysis in nephropathology,” Dr. Ulysses G. J. Balis discussed how the emergence of digital pathology — an image-based environment for the acquisition, management, and interpretation of pathology information supported by computational techniques for data extraction and analysis — is changing the pathology ecosystem [...]

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In a broadly collaborative effort, Pathology faculty Drs. Carl Schmidt, Jeffrey Myers, Kristine Konopka, Paul Lephart, and Teresa Nguyen joined Michigan Medicine faculty from the departments of Epidemiology, Internal Medicine, Microbiology and Immunology, Mathematics and Complex Systems, and the School of Public Health in a study published in Clinical Infectious Diseases entitled “SARS-CoV-2 surveillance in decedents in a large, urban medical examiner’s office.”

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New research related to H3K27M-mutant diffuse midline glioma with extensive intratumoral microthrombi in young adults with COVID-19 from the Department of Pathology was just published in Acta Neurologica. [...]

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Research from Dr. Analisa Difeo was just published in Nature Communications. The study focuses on miR-181a and how it initiates and perpetuates oncogenic transformation through the regulation of innate immune signaling [...]

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The publication takes an in-depth examination of diffuse alveolar damage (DAD) caused by COVID-19 and how it is morphologically indistinguishable from other causes of DAD.

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Dr. Jeffrey Myers discusses the importance of frontline workers and their caring of patients - alive or deceased - during the COVID-19 pandemic.

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The research, which focuses on invasive squamous cell carcinomas and the precursor lesions that demonstrate concordic genomic complexity in driver genes, was just published in Modern Pathology.

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The research was just published in Histopathology and features prominent contributions from our faculty.

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The Department of Pathology 2019 Annual Report is now available online. Our department continues to show outstanding performance and growth and the past year was another example of why our department is one of the best in the world.

In the report, you will read about [...]

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The study pertains to the molecular characterization of uterine and ovarian tumors and their relationships to epithelial and germ cell features by somatic derivation.

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The study sheds light on alternative methods used for measuring size and depth of vulvar squamous cell carcinoma.

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A new study from the Andrew Lieberman Laboratory’s Samir Nath, et al, has discovered that MEF2 impairment underlies skeletal muscle atrophy in polyglutamine disease.

Kennedy’s Disease, also known as Spinal and Bulbar Muscular Atrophy (SBMA), is a disease caused by an inherited gene mutation that results in muscle and brain cell dysfunction. Patients progressively lose muscle mass until they are unable to walk without assistance. Ultimately [...]

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Researchers have uncovered the gene signature for ChRCC.

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The study details research surrounding Respiratory Syncytial Virus (RSV) among infants.

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Resolvin E1 (RvE1), a lipid derived from Omega-3 fatty acids, is a pro-repair molecule that promotes healing of intestinal wounds according to a recent study published in PNAS as a collaborative project between The Department of Pathology at the University of Michigan Medical School and [...]

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Modern Pathology recently published a multi-institutional study led by pathology faculty Dr. Rohit Mehra; other participating centers included The Cleveland Clinic, Emory School of Medicine and Memorial Sloan Kettering Cancer Center. Third year Pathology resident at Michigan Medicine, Alex Taylor, MD, was the first author with other major contributions by Drs. Noah Brown and May Chan. [...]

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Mark Schultz, PhD, and Andrew Lieberman MD, PhD, have published “Synthetic high-density lipoprotein nanoparticles for the treatment of Niemann–Pick diseases” in BMC Medicine. [...]

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Department faculty outreach to high school students to educate about careers in medicine and research.

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Our department's clinical resident Alex Taylor, MD, joined postdoctoral fellow Rahul Mannon, PhD, and other researchers from the Department of Pathology and the Michigan Center for Translational Pathology, who found that patients with a long-standing history of prostate cancer and other prostatic issues can find difficulty [...]

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Two Michigan Medicine Fellows, Caroline Simon, MD, and Stephanie Skala, MD, (who recently joined the Department of Pathology as faculty), joined colleagues from the Michigan Center for Translational Pathology, in a research study published in Diagnostic Pathology dated October 21, 2019 [...]

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Bryan Betz, PhD, was inspired by his late wife, Sharon, to pursue a career in clinical diagnostics.

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A look at the artists behind the artwork hung in the newly renovated facility.

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A study by Drs. Emily McMullen, Paul Harms, Lori Lowe, Doug Fullen, and May Chan is published in the September issue of the American Journal of Surgical Pathology (AJSP). Calciphylaxis is a dermatologic emergency where an accurate and timely diagnosis is crucial but [...]

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In collaboration with Drs. Luke Nayak and Arjun Sondhi, Dr. Maria Westerhoff published a report in Gastroenterology titled, "A Rare Complication of a Rare Disease" documents a case of erythropoietic protoporphyria, a rare condition that can affect the liver [...]

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The Fifth Edition of Histology for Pathologists has just been published by Wolters Kluwer and Maria Westerhoff, MD, and Joel Greenson, MD, co-wrote the chapter on colon histology. The newest edition of this award-winning book is a comprehensive collection of normal histology written by anatomic pathologists for anatomic pathologists. The book is designed to [...]

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Unique structure of circRNA makes it an ideal candidate for biomarkers – and it can be detected in blood or urine.

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A new U-M initiative aims to improve the patient experience by forging connections between pathologists and the people they serve.

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Dr. Sameer Khatri along with the Department of Pathology's Drs. Min Wang, Paul Harms, Douglas Fullen, Aleodor Andea, and May Chan, in collaboration with other U-M [...]

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The Review Article, Innate immune responses to trauma, was released today in Nature Immunology. This work, by Markus Huber-Lang of the University Hospital of Ulm, Institute of Clinical and Experimental Trauma-Immunology in Ulm Germany, John D. Lambris of the University of Pennsylvania School of Medicine, Department of Pathology [...]

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Clinical FISH Assays for TFE3 and TFEB Help Characterize Renal Cell Carcinoma.

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The work entitled The Utility of SDHB and FH Immunohistochemistry in Patients Evaluated for Hereditary Paraganglioma-Pheochromocytoma Syndromes by Aaron M. Udager, MD, PhD, and colleagues in the Department of Pathology was published in Human Pathology on [...]

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