Faculty and Trainees Work to Understand Therapy-Resistant Malignancies

By Lidija Fremeau | October 30 2019

Two Michigan Medicine Fellows, Caroline Simon, MD, and Stephanie Skala, MD, (who recently joined the Department of Pathology as faculty), joined colleagues from the Michigan Center for Translational Pathology, in a research study Stephanie Skalapublished in Diagnostic Pathology dated October 21, 2019.  This article reports that rapid (“warm”) autopsies performed within three hours of death of end-stage cancer patients help us to understand the clinical and pathological aspects of therapy-resistant malignancies.

Caroline SimonIn one particular case, the MLTP Program at Michigan Medicine/MCTP found a patient with recurrent Plasmacytoid Urothelial Carcinoma (PUC) had persistent disease after cystoprostatectomy. Shortly before death, imaging showed only subtle growth along vascular tissue planes; however, extensive disease was seen on autopsy. In conclusion, more vigilant and alternative forms of surveillance may be required for detection of recurrent PUC.  Their findings highlight the unique clinical, pathologic, and genomic profile encountered in such patients.

The full article can be found at: www.ncbi.nlm.nih.gov