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  • Ogura, Y., Bonen, D.K., Inohara, N., Nicolae, D.L., Chen, F.F., Ramos, R., Britton, H., Moran, T, Karaliuskas, R., Duerr, R.H., Achkar, J-P., Brant, S.R., Bayless, T.M., Kirschner, B.S., Hanauer, S.B., Nuñez, G.,* and Cho, J.H.* (*joint senior authors). A frameshift mutation in Nod2 associated with susceptibility to Crohn's disease. Nature 411:603-606 (2001).

  • Kanneganti T-D, Özören N, Body-Malapel M, Amer A, Park J-P, Franchi L, Whitfield J, Barchet W, Colonna M, Vandenabeele P, Bertin J,  Coyle A, Grant EP, Akira S,  Núñez G. Bacterial RNA and Small Antiviral Compounds Activate Caspase-1 Through Cryopyrin/Nalp3. Nature 440:223-236 (2006).

  • Franchi L, Amer A, Body-Malapel M, Kanneganti TD, Ozoren N, Jagirdar R, Inohara N, Vandenabeele P, Bertin J, Coyle A, Grant EP, Núñez G. Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat Immunol. 7:576-582 (2006). 

  • Kanneganti TD, Lamkanfi M, Kim YG, Chen G, Park JH, Franchi L, Vandeenabeele P, Núñez G.  Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptors Signaling. Immunity 26:433-443 (2007).

  • Kim YG, Park J-P, Shaw MH, Franchi L, Inohara N and Núñez G.  Nod1 and Nod2 are Critical for Intracellular Bacterial Sensing and Host Defense after Exposure to Toll-like Receptors Ligands.  Immunity, 28:246-57 (2008).

  • Shaw MH, Reimer T, Sánchez-Valdepeñas C, Warner N, Kim YG, Fresno M, Nuñez G. T cell-intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii. Nature  Immunol.12:1267-1274 (2009).

  • Kim YG, Kamada N., Shaw MH, Warner N., Chen GY, Franchi L., and Núñez G. Nod2 Orchestrates Immune Responses that Promote Intestinal Pathogen Eradication via CCL2-Dependent Recruitment of Inflammatory Monocytes. Immunity 34:769-780 (2011).

  • Kim YG, Park J-H, Reimer T, Baker DP, Kawai T, Kumar H, Shizuo Akira S,Wobus C, and Núñez G. Nod1 and Nod2 Signaling Augmented by Viral Infection through Type I Interferons Potentiate Lethality Induced by Secondary Bacterial Infection. Cell Host & Microbe 16:9:496-507 (2011).