Dr. Chang H. Kim and the Immunology & Hematopoiesis Lab

Overview of Research

Isolator-small.jpgMajor research areas

  • Mucosal immunology, inflammation, and cancer
  • Migration of innate immune cells and lymphocytes
  • Development  of T cells (FoxP3+, Tr1, andTh17 cells)  and dendritic cells in health and disease
  • Roles of vitamin A  and retinoic acid in regulation of the immune system
  • Roles of microbial metabolites (short chain fatty acids) in regulation of the immune system
  • Roles of hormones in regulation of the immune system
  • Regulation of Tfh, GC-T cells, and B cell antibody production
  • Gut Microbiota and Immune Responses (below: Purdue Germ-Free Animal Facility)

 

Cell trafficking and function in the hematolymphoid system

 

Cell trafficking and function in the hematolymphoid system

We study trafficking mechanisms of lymphocytes for development and effector functions. Special emphasis is on the roles of chemokine receptors and integrins in regulation of the trafficking of various T cell populations (Th17, Th1, Tfh, Tfr, IL-10+ T cells, and FoxP3+ Tregs) and innate lymphoid cells (ILCs).

 

Mucosal immunity, inflammation, and cancer

 

Mucosal immunity, inflammation, and cancer

Balanced immunity is important for prevention of inflammation and cancer. We study the interactive relationships among immunity, inflammation and cancer development in the intestine. The cooperative roles of T cells, B cells, dendritic cells and innate lymphoid cells are studied.

 

Host and microbial metabolites in regulation of the immune system

 

Host and microbial metabolites in regulation of the immune system

Metabolites produced from dietary factors play important roles in regulation of immunity and inflammation. We study the roles of short-chain fatty acids (SCFAs) and retinoic acid. Short-chain fatty acids are produced by gut commensal bacteria from fermentation of dietary fibers. Retinoic acid is produced from vitamin A. These two different types of metabolites promote immunity and prevent inflammatory responses in the body. In addition, we study the functions of sex hormones and related factors in regulation of immunity and inflammatory processes.

 


 

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