Dr. Chang H. Kim and the Immunology & Hematopoiesis Lab

Selected Publications

Citation Impact   PUBMED

Major Topics


Microbial metabolites, short-chain fatty acids, and the immune system Kim CH. B cell-helping functions of gut microbial metabolites. Microbial cell (Graz, Austria). 2016; 3(10):529-531.

Kim M, Qie Y, Park J, Kim CH. Gut Microbial Metabolites Fuel Host Antibody Responses. Cell host & microbe. 2016; 20(2):202-14.

Park J, Kim M, Kang SG, Jannasch AH, Cooper B, Patterson J, Kim CH. Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathway. Mucosal Immunol. 2014 Jun 11. doi: 10.1038/mi.2014.4

Kim CH, Park J, Kim M. Gut microbiota-derived short-chain Fatty acids, T cells, and inflammation.
Immune Netw. 2014 Dec;14(6):277-88. doi: 10.4110/in.2014.14.6.277. Epub 2014 Dec 22. Review.

Kim CH. Host and microbial factors in regulation of T cells in the intestine. Frontiers in Immunology. 2013 Jun 10;4:141. doi: 10.3389/fimmu.2013.00141. 

Kim MH, Kang SG, Park JH, Yanagisawa M, Kim CH. Short-Chain Fatty Acids Activate GPR41 and GPR43 on Intestinal Epithelial Cells to Promote Inflammatory Responses in Mice. Gastroenterology. 2013 May 7. doi:pii: S0016-5085(13)00708-7. 10.1053/j.gastro.2013.04.056
Vitamin A, retinoic acid and the immune system Hashimoto-Hill S, Friesen L, Kim M, Kim CH. Contraction of intestinal effector T cells by retinoic acid-induced purinergic receptor P2X7. Mucosal immunology. 2017; 10(4):912-923. NIHMSID: NIHMS828140

Kim MH, Taparowsky EJ, Kim CH. Retinoic Acid Differentially Regulates the Migration of Innate Lymphoid Cell Subsets to the Gut.  Immunity.  2015; 43(1):107-19. NIHMSID: NIHMS698201 View

Wang C, Thangamani S, Kim M, Gu BH, Lee JH, Taparowsky EJ, Kim CH. BATF is required for normal expression of gut-homing receptors by T helper cells in response to retinoic acid. J Exp Med. 2013 Mar 11;210(3):475-89.

Kim CH. Retinoic acid, immunity, and inflammation. Vitam Horm. 2011;86:83-101.

Chang J, Thangamani S, Kim MH, Ulrich B, Morris SM Jr, Kim CH. Retinoic acid promotes the development of Arg1-expressing dendritic cells for the regulation of T-cell differentiation. Eur J Immunol. 2013 Apr;43(4):967-78. 

Kang SG, Park J, Cho JY, Ulrich B, Kim CH. Complementary roles of retinoic acid and TGF-beta1 in coordinated expression of mucosal integrins by T cells. Mucosal Immunol. 2011, PMID: 20664575

Kang SG, Wang C, Matsumoto S, Kim CH. High and low vitamin A therapies induce distinct FoxP3+ T cell subsets and effectively control intestinal inflammation. Gastroenterology. 2009 Oct;137(4):1391-402.

Kang SG, Lim HW, Andrisani OM, Broxmeyer HE, Kim CH. Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells. J Immunol. 2007, 179(6):3724-33.
T follicular helper (Tfh)  and regulatory (Tfr) cells and regulation of humoral immunity Kim CH, Hashimoto-Hill S, Kang SG. Human Tfh and Tfr cells: identification and assessment of their migration potential. Methods Mol Biol. 2015;1291:175-86. doi: 10.1007/978-1-4939-2498-1_15.

Betz BC, Jordan-Williams KL, Wang C, Kang SG, Liao J, Logan MR, Kim CH, Taparowsky EJ. Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J Exp Med. 2010 Apr 26.

Lim HW, Kim CH. Loss of IL-7 Receptor alpha on CD4+ T Cells Defines Terminally Differentiated B Cell-Helping Effector T Cells in a B Cell-Rich Lymphoid Tissue. J Immunol. 2007, 179:7448-56.

Kim CH. Regulation of humoral immunity by FoxP3+ regulatory T cells. Expert Review of Clinical Immunology, 2006. Vol. 2(6): 859-868.

Kim JR, Lim HW, Hillsamer P, Kim CH. Human CD57+ germinal center-T cells are the major helpers for GC-B cells and induce class switch recombination. BMC Immunology 2005, 6:3.

Lim, HW, Hillsamer P, Banham AH, and Kim CH, Cutting Edge: Direct Suppression of B Cells by CD4+CD25+ Regulatory T Cells , J Immunol 2005 175: 4180-4183.

Lim HW, Hillsamer P, Kim CH. Regulatory T cells acquire migratory capacity to follicles upon T cell activation and suppress GC-T helper cell-driven B cell responses. 2004, J. Clin. Invest. 114:1640-1649.

Kim CH, Campbell DJ, and Butcher EC, Nonpolarized memory T cells. 2001, Trends in Immunology. 22:527-530.

Kunkel EJ, Kim CH, Lazarus NH, Vierra MA, Soler D, Bowman EP, Butcher EC. CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. J Clin Invest. 2003, 111:1001-10.

Roy M, Kim CH, Butcher EC. Cytokine regulation of B cell homing machinery. 2002, J. Immunol. 169:1676.

Campbell DJ, Kim CH and Butcher EC, Separable populations of effector CD4+ T cells mediate B cell help and tissue inflammation. 2001, Nature Immunology, 9:876-881.

Kim CH, Rott LS, Clark-Lewis I, Campbell DJ, Wu L, Butcher EC. Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells. 2001, J. Exp. Med. 193:1373.

Kim CH, Pelus LM, White JR, Appelbaum E, Johanson K, and Broxmeyer HE, CKb-11/MIP-3b/ELC is an efficacious chemoattractant for T- and B-cells. J. Immunol., 1998, 160:2418-2424.
Trafficking and function of effector T cells (Th1, Th2, Th9, Th17, NKT etc) Kim CH, Hashimoto-Hill S, Kim M. Migration and Tissue Tropism of Innate Lymphoid Cells. Trends in immunology. 2016.

Jabeen R, Goswami R, Awe O, Kulkarni A, Nguyen ET, Attenasio A, Walsh D, Olson MR, Kim MH, Tepper RS, Sun J, Kim CH, Taparowsky EJ, Zhou B, Kaplan MH.  Th9 cell development requires a BATF-regulated transcriptional network. J Clin Invest. 2013 Oct 8. pii: 69489. doi: 10.1172/JCI69489.

Wang C, Kang SG, Hogenesch H, Love PE, Kim CH. Retinoic Acid Determines the Precise Tissue Tropism of Inflammatory Th17 Cells in the Intestine. J Immunol. 2010, 184, 5519 -5526 

Wang C, Kang SG, Lee J, Sun Z, Kim CH. The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut. Mucosal Immunol. 2009 Mar;2(2):173-83.

Lim HW, Lee J, Hillsamer P, Kim CH. Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3+ regulatory T cells. J Immunol. 2008 Jan 1;180(1):122-9.

Kim CH. The greater chemotactic network for lymphocyte trafficking: Chemokines and beyond. Current Opinion in Hematology 2005, 12:298-304.

Kim CH, Lim HW, Kim JR, Rott L, Hillsamer P, Butcher EC. Unique gene expression program of human germinal center T cells. 2004. Blood. 104: 1952-1960.

Johnston B, Kim CH, Soler D, Emoto M, Butcher EC. Differential chemokine responses and homing patterns of murine TCRalphabeta NKT cell subsets. J Immunol. 2003, 171:2960-9.

Kim CH, Nagata K, and Butcher EC. Dendritic Cells Support Sequential Reprogramming of Chemoattractant Receptor Profiles During Naive to Effector T Cell Differentiation. J. Immunol. 2003. 171(1):152-8.

Campbell DJ, Kim CH, Butcher EC. Chemokines in the systemic organization of immunity. Immunol Rev. 2003, 195:58-71.

Kim CH, Butcher EC, Johnston B. Distinct subsets of human Va24-invariant NKT cells. 2002, Trends in Immunology, 23:516-9.

Kim CH, Johnston Brent and Butcher EC, Trafficking machinery of NKT cells: differential chemokine receptor expression among NKT cell subsets with distinct cytokine-producing capacity. 2002, Blood. 2002;100:11-16.

Andrew DP, Ruffing N, Kim CH (co-first authors), Miao A, Heath H, You-Li, Murphy K, Butcher EC, Wu L, CCR4 expression defines a major subset of circulating non-intestinal memory T cells of both Th1 and Th2 potential. 2001, J. Immunol.166:103.

Kim CH, Kunkel, EJ, Boisvert J, Johnston B, Campbell JJ, Genovese MC, Greenberg HB, and Butcher EC. Bonzo/CXCR6 defines polarized Type 1 memory/effector T cell subsets with extra-lymphoid tissue homing potential. 2001, J. Clin. Invest.107: 595.

Kim CH, Rott LS, Kunkel EJ, Genovese M, Andrew DP, Wu L, and Butcher EC. Rules of chemokine receptor association with T cell polarization in vivo. 2001, J. Clin. Invest, 108:1331.
Hematopoietic stem and progenitor cells and their migration Park J, Lee JW, Cooper SC, Broxmeyer HE, Cannon JR, Kim CH. Parkinson disease-associated LRRK2 G2019S transgene disrupts marrow myelopoiesis and peripheral Th17 response. Journal of leukocyte biology. 2017; 102(4):1093-1102.

Broxmeyer HE, Cooper S, Hangoc G, Kim CH. Stromal cell-derived factor-1/CXCL12 selectively counteracts inhibitory effects of myelosuppressive chemokines on hematopoietic progenitor cell proliferation in vitro. 2005. Stem Cells Dev. 14: 199-203.

Kim CH, Qu C, Hangoc G, Cooper S, Feng G-S, and Broxmeyer HE, Abnormal chemokine induced responses of immature and mature hematopoietic cells from motheaten mice: Implication of the protein tyrosine phosphatase SHP-1 in chemokine responses, 1999, J. Exp. Med., 190:681-690.

Youn BS, Kim CH, Smith F, Broxmeyer HE, TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9-6/CCR9 as a specific receptor. 1999, Blood. 94:2533-2536.

Kim CH, Hangoc G, Cooper S, Helgason CD, Yew S, Humphries RK, Krystal G, and Broxmeyer HE, Altered responsiveness to chemokines due to targeted disruption of SHIP. 1999, J. Clin. Invest. 104:1751.
Kim CH, Pelus LM, White JR, and Broxmeyer HE. Rapid communication: Differential chemotactic behavior of developing T cells in response to thymic chemokines. Blood, 1998, 91:4434-4443.

Kim CH, Pelus LM, White JR, and Broxmeyer HE. MIP-3b/ELC/CKb-11, a CC chemokine, is a chemoattractant for myeloid progenitor cells with a specificity for macrophage progenitors. J. Immunol., 1998, 161:2580-2585.

Hromas R, Kim CH, Klemsz M, Krathwohl M, Fife K, et al.Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension. Journal of immunology. 1997; 159(6):2554-8.
Progesterone and the immune system Thangamani S, Kim M, Son Y, Huang X, Kim H, Lee JH, Cho J, Ulrich B, Broxmeyer HE, Kim CH.Cutting edge: progesterone directly upregulates vitamin d receptor gene expression for efficient regulation of T cells by calcitriol. J Immunol. 2015 Feb 1;194(3):883-6.

Kim CH, A functional relay from progesterone to vitamin d in the immune system. DNA Cell Biol. 2015 Jun;34(6):379-82. doi: 10.1089/dna.2015.2857. Epub 2015 Mar 31.

Lee JH, Lydon JP, Kim CH. Generation of induced regulatory T cells with improved stability and suppressive activity with progesterone. Eur. J. Immunol. 2012 Jun 28. doi: 10.1002/eji.201142317

Lee JH, Ulrich B, Cho J, Park J, Kim CH. Progesterone promotes differentiation of human cord blood fetal T cells into T regulatory cells but suppresses their differentiation into Th17 cells. J Immunol. 2011 Aug 15;187(4):1778-87. PMID: 21768398

Broxmeyer HE, Cooper S, Kohli L, Hangoc G, Lee Y, Mantel C, Clapp DW, Kim CH. Transgenic Expression of Stromal Cell-Derived Factor-1/CXC Chemokine Ligand 12 Enhances Myeloid Progenitor Cell Survival/Antiapoptosis In Vitro in Response to Growth Factor Withdrawal and Enhances Myelopoiesis In Vivo. J. Immunol. 2003, 170:421-429.
Trafficking and function of Tregs Lee JH, Wang C, Kim CH. FoxP3+ regulatory T cells restrain splenic extramedullary myelopoiesis via suppression of hemopoietic cytokine-producing T cells. J Immunol. 2009 Nov 15;183(10):6377-86.

Kang SG, Piniecki RJ, Hogenesch H, Lim HW, Wiebke E, Braun SE, Matsumoto S, Kim CH.  Identification of a chemokine network that recruits FoxP3(+) regulatory T cells into chronically inflamed intestine. Gastroenterology. 2007, 3: 966-81.

Kim CH. Reining in FoxP3(+) regulatory T cells by the sphingosine 1-phosphate-S1P1 axis. Immunol Cell Biol. 2009 Oct;87(7):502-4.

Lee JH, Kang SG, Kim CH. FoxP3+ T cells undergo conventional first switch to lymphoid tissue homing receptors in thymus but accelerated second switch to non-lymphoid tissue homing receptors in secondary lymphoid tissues. 2007, J Immunol 2007 178: 301-311.

Kim CH. Migration and function of Foxp3+ regulatory T cells in hematolymphoid system (review). Exp. Hematol. 2006, 34:1033-40.

Lim HW, Broxmeyer HE, Kim CH. Regulation of trafficking receptor expression in human forkhead box p3+ regulatory T cells. J Immunol. 2006 177(2):840-51.
Cell migration in cancer Wang C, Lee JH, Kim CH. Optimal population of FoxP3+ T cells in tumors requires an antigen priming-dependent trafficking receptor switch. 2012. PLOS One. 2012;7(1):e30

Braun SE, Chen SE, Foster RG, Kim CH, Hromas R, Broxmeyer, HE, Cornetta K, The CC chemokine CKb-11/MIP-3b/ELC/Exodus3 mediates tumor rejection of murine breast cancer cells through natural killer cells. 2000, J. Immunol. 164:4025.