University of Michigan
Kleer Laboratory
Welcome to the laboratory of Celina G. Kleer, M.D., Harold A. Oberman Collegiate Professor of Pathology at the University of Michigan Medical School.
Breast cancer has killed millions of women and continues to be responsible for over 44,000 deaths each year in this country. Morphology and current prognosticators do not allow accurate prediction of progression and metastasis, indicating that some breast cancers, despite grade and size at diagnosis, have the ability to invade and metastasize early in their development, unbeknownst to both patient and clinician. Our laboratory focuses on discovering better ways of identifying breast cancers with a propensity to metastasize. To this end, we are devoted to understanding major mechanisms of breast cancer initiation and progression and in translating them into clinical utility. We use histopathology, cellular, and mouse models.
In the next pages, you will find details about our laboratory projects. Please feel free to contact us for additional information.
Rogel Cancer Center
1500 E. Medical Center Dr.
Ann Arbor, 48109
ph. (734) 936-6775 / (734) 615-3448
f. (734) 763-4095
e. kleer@umich.edu
Understanding the mechanisms by which EZH2 promotes breast cancer metastasis.
Investigation of the tumor suppressor function of CCN6, a matrix-associated protein, in breast cancer.
Elucidating the role and mechanism of mesenchymal stem/stromal cells (MSCs) in the tumor microenvironment on breast cancer progression.
Utilization of state of the art transcriptome analyses and quantitative proteomics, and proteogenomics to understand defining molecular alterations in breast cancer.
News & Highlights See All
Dr. Celina Kleer: Physician Scientist, Dedicated Mentor, ASIP Outstanding Investigator Awardee
Dr. Celina Kleer named 2019 AACR Outstanding Investigator in Breast Cancer Research
Study from Kleer and Nesvizhskii Labs Reveals the Proteomic Landscape of Metaplastic Breast Carcinomas
Along with co-investigators, Sabra Djomehri, a graduate student in Celina Kleer's Laboratory, has discovered the proteomic landscape of metaplastic carcinomas, the most aggressive type of triple negative breast cancer. The study, published in [...]
Kleer honored by the AACR
The American Association for Cancer Research announced that Celina Kleer, MD, the Harold A. Oberman Collegiate Professor of Pathology and Director of the Breast Pathology Program, will be the recipient of the 2019 Outstanding Investigator in Breast Cancer Research, supported by the Breast Cancer Research Foundation.
By Cannibalizing Nearby Stromal Stem Cells, Some Breast Cancer Cells Gain Invasion Advantage
Cancer biologists and engineers collaborated on a device that could help predict the likelihood of breast cancer metastasis.
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