Point of Care

Home POCT Contacts & Location Access & Barcodes Glucometer Exchange POCT Procedures & Logs Training Resources POCT Supplies Frequently Asked Questions (FAQs) New Test Request Health & Safety Manual Contact Information
  1. Home
  2. Urine Drug Screen Facts

Point of Care Urine Drug Screen Facts

The Point of Care Urine Drug Screen is an immunoassay drug screening test that provides only preliminary test results for drugs of abuse.  For a quantitative result or to confirm results obtained by the Point of Care Urine Drug Screen, a more specific alternative method must be used.  Mass spectometery (MS) is the preferred confirmatory method.  Contact the Toxicology laboratory at 734-936-6758 or the Pathology Handbook for more information.

 

The Point of Care Urine Drug Screen is for medical purposes only.  It is not intended for employment or legal testing purposes.

 

Drug Classes detected, cut-off calibrator concentrations used, and estimated concentration of other drugs in each class to produce a positive response:

AMP Amphetamine Cut-off calibrator is 1000 ng/mL d-Amphetamine

Substance Conc. (ng/mL) Substance Conc. (ng/mL)
AMP 1000
d-Amphetamine 1,000 l-Amphetamine 50,000
d,l-Amphetamine 3,000 (+/-) 3,4-
Methylenedioxyamphetamine
(MDA)		 5,000
Phentermine 3,000 d-Methamphetamine >100,000
l-Methamphetamine >100,000 Ephedrine >100,000
(+/-) 3,4-
Methylenedioxymethamphetamine
(MDMA)		 100,000 Hydroxyamphetamine 8,000
β-Phenylethylamine  100,000  p-Hydroxynorephedrine 100,000
Tyramine  100,000 (±) Phenylpropanolamine >100,000
Phenylpropanolamine >100,000 d/l-Norephedrine 100,000
p-Hydroxyamphetamine 100,000 l-Ephedrine >100,000
Benzphetamine >100,000 d/l-Epinephrine >100,000
l-Epinephrine >100,000    

 

MET Methamphetamine Cut-off is 1000 ng/mL D(+)-Methamphetamine

Substance Conc. (ng/mL) Substance Conc. (ng/mL)
MET 1000
d-methamphetamine 1,000 l-phenylephrine >100,000
p-Hydroxymethamphetamine 30,000 Mephentermine 50,000
l-methamphetamine 25,000 (+/-) 3,4-
Methylenedioxyethylamphetamine
(MDEA)		 1,000
D/L-Methamphetamine 1,000 D-Amphetamine 100,000
L-Amphetamine 75,000 Chloroquine 50,000
(+/-)-Ephedrine 50,000 (-)-Methamphetamine 25,000
(+/-) 3,4-Methylenedioxyamphetamine
(MDA)		 1,000 (+/-) 3,4-
Methylenedioxymethamphetamine
(MDMA)		 4,000
β-Phenylethylamine 50,000 Trimethobenzamide 10,000
d,l-Amphetamine 100,000 (1R,2S)-(-)-Ephedrine 100,000

 

BAR Barbituraes Cut-off is 300 ng/mL Secobarbital

Substance Conc. (ng/mL) Substance Conc. (ng/mL)
BAR 300
Secobarbital

300

 Butathal 100
Amobarbital 10,000 Butalbital 2,500
Alphenol 150 Cyclopentobarbital 600
Aprobarbital 200 Pentobarbital 2,500
Butabarbital 75 Phenobarbital 10,000

 

BZO Benzodiazepines Cut-off is 300 ng/mL Oxazepam

Substance Conc. (ng/mL) Substance Conc. (ng/mL)
BZO 300
Oxazepam 300 Diazepam 200
Alprazolam 200 Estazolam 1,000
α-Hydroxyalprazolam 1,500 Flunitrazepam 2,500
Bromazepam 500 D,L-Lorazepam 1,500
Chlordiazepoxide 1,500 Midazolam 12,500
Clobazam 100 Nitrazepam 4,000
Clonazepam 800 Norchlordiazepoxide 200
Clorazepate dipotassium 200 Nordiazepam 500
Delorazepam 1,500 Temazepam 250
Desalkylflurazepam 400 Triazolam 1,200
Demoxepam 2,000 Flurazepam 500

 

COC Cocaine Cut-off is 300 ng/mL Benzoylecgonine

Substance Conc. (ng/mL) Substance Conc. (ng/mL)
 COC 300
Benzoylecgonine 300 Ecgonine 32,000
Cocaine 750 Ecgonine methyl ester >100,000
Cocaethylene 12,500 Norcocaine >100,000

 

THC Cannabinoids Cut-off is 50 ng/mL 11-nor-∆9-THC-9-COOH

Substance Conc. (ng/mL) Substance Conc. (ng/mL)
 THC 50
11-nor-∆9-THC-9-COOH 50 ∆9-Tetrahydrocannabinol 5,000
11-nor-∆8-THC-9-COOH 30 Cannabinol 20,000
11-hydroxy-∆9-Tetrahydrocannabinol 5,000 Cannabidiol 100,000
∆8-Tetrahydrocannabinol 1,300 11-nor-∆9-THC-carboxyglucuronide 100

 

OPI Opiates/Morphine Cut-off is 300 ng/mL of Morphine

Substance Conc. (ng/mL) Substance Conc. (ng/mL)
 MOP 300
Morphine 300 Morphinie-3-β-d-glucuronide 1,000
Codeine 300 Norcodeine 6,250
Ethyl Morphine 100 Normorphine 300
Heroin 300 Oxycodone 10,000
Hydrocodone 5,000 Oxymorphone 10,000
Hydromorphone 1,000 Procaine 150,000
6-Monoacetylmorphine (6-MAM) 150 Thebaine 3,000
Levorphanol 10,000    

 

OXY Oxycodone Cut-off is 100 ng/mL of Oxycodone

Substance Conc. (ng/mL) Substance Conc. (ng/mL)
 OXY100
Oxycodone 100 Codeine 100,000

 

MTD Methadone Cut-off is 300 ng/mL Methadone

Substance Conc. (ng/mL) Substance Conc. (ng/mL)
 MTD300
Methadone 300 Doxylamine 50,000
EMDP >100,000 EDDP >100,000
LAAM >100,000 Alpha Methadol >100,000

 

BUP Buprenorphrine Cut-off is 10 ng/mL of Buprenorphrine

Substance Conc. (ng/mL) Substance Conc. (ng/mL)
 BUP10
Buprenorphine 10 Norbuprenorphine 20
Buprenorphine-3-D-Glucuronide 15 Norbuprenorphine-3-D-Glucuronide 200
Morphine >100,000 Oxymorphone >100,000
Hydromorphone >100,000    

 

Unexpected Results-if results are different than expected, confirmatory testing should be ordered.  Contact the Toxicology Lab for advice on confirmatory testing.  Below are some considerations with regard to detection of particular drugs by the assay:

  1. Amphetamine. Methylphenidate, labetalol, trazodone, and ranitidine are LIKELY NOT detected by the amphetamine strip.
  2. Morphine (opiates). Codeine IS detected. Fentanyl and tramadol ARE NOT detected by the morphine strip. Methadone, buprenorphine also ARE NOT detected by the morphine strip but have their own strips in the assay. Oxycodone MAY be detected at very high levels but does have its own strip in the assay. Hydromorphone and hydrocodone MAY be detected by the morphine strip at higher levels. Poppy seed ingestion MAY be detected.
  3. Oxycodone. Hydrocodone MAY be detected on the oxycodone strip if present at very high concentrations.
  4. Benzodiazepines. Due to glucuronidation, lorazepam IS LIKELY NOT detected well and on most occasions will not be detected even if the patient is taking the drug. Clonazapam MAY be detected at high levels.
  5. Methadone. Doxylamine is LIKELY NOT detected except at very high concentrations.
  6. Regarding compliance testing, several assays will detect the parent drug as well as metabolites but these cannot be distinguished from each other: Buprenorphine, Morphine (opiates), Benzodiazepine.

 

1. What does a positive result mean?

  1. The patient is compliant, taking the drug as prescribed.
  2. Patient is partially compliant.
  3. Patient taking another drug which produces a positive result in the test.

2. What does a negative result mean?

  1. Patient is not compliant, not taking the drug.
  2. Patient taking the drug incorrectly (lower dose, less frequent)
  3. The drug is present but below the cut-off concentration for a positive test.
  4. Altered pharmacokinetic variables such as poor absorption, rapid metabolism.
  5. The test does not detect the prescribed drug.
  6. Diluted or adulterated sample.

3. Window of detection

Drug (Identifier) Cut-off Level (ng/ml) Minimum Detection Time Maximum Detection Time
Amphetamine (AMP) 1000

2-7 hours

 1-2 days
Barbiturates (BAR) 300 2-4 hours 1-4 days
Buprenorphine (BUP) 10 4 hours 1-3 days 
Benzodiazepine (BZO) 300 2-7 hours

1-2 days
Cocaine (COC) 300 1-4 hours 2-4 days
Methamphetamine(MET) 1,000 2-7 hours 2-4 days 
Morphine (MOP) 300 2 hours 2-3 days
Oxycodone (OXY) 100 4 hours

1-3 days
Methadone (MTD) 300 3-8 hours 1-3 days
Marijuana (THC) 50 2 hours Up to 5+ days

 

References:

Alere iSCREEN Urine Test DX Drug Screen Square Cup Package Insert. Distributed by Instant Technologies, Inc., Portsmouth VA 23704 USA. 2022 Abbott Rel.:2022/10/28

 

The most recent version of the drug screen facts will be held in MediaLab Job Aid 136707.187. Contact POCT at PATH-POC-Offsite@med.umich.edu if you need the current version. POCT updates the webpage as new versions are approved.