Pathology News

Drs. Udager, Dhanasekaran, and Mehra publish new paper in the AJSP: Reviews & Reports

By Dustin Johnston | 1 December

Aaron Udager, MD, PhD, Saravana Dhanasekaran PhD, and Rohit Mehra MD have published Mucinous Tubular and Spindle Cell Carcinoma: Case Report and Review of an Uncommon Renal Tumor in the American Journal of Surgical Pathology: Reviews and Reports. An image from their case report was also included on the cover of the journal.

The abstract from the paper reads, "Mucinous tubular and spindle cell carcinoma (MTSCC) is an uncommon renal tumor with characteristic morphologic features but overlapping immunophenotype with papillary renal cell carcinoma. Recent genomic and transcriptomic analysis of MTSCC has uncovered recurrent chromosomal losses and frequent biallelic alteration of Hippo pathway genes, resulting in increased YAP1 nuclear expression. In this article, we describe a case of MTSCC and review the pertinent clinical, morphologic, immunohistochemical, and molecular findings of this uncommon kidney tumor. In the era of personalized medicine, increased pathologic recognition of MTSCC may facilitate targeted therapeutic approaches (ie, the YAP1 small molecule inhibitor verteporfin) for rare patients with aggressive tumors."

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