Bachman Lab

The Bachman lab studies the gram-negative bacterial pathogen Klebsiella pneumoniae, its mechanisms of pathogenesis, and the host response to infection.

K. pneumoniae is a common cause of hospital-acquired infections, including urinary tract infections, bloodstream infections, and pneumonia. These infections are increasingly difficult to treat due to antibiotic resistance. Recently, strains of K. pneumoniae have emerged in the United States and throughout the world that are resistant to carbapenems, antibiotics of last resort against severe gram-negative infections. Carbapenem resistant K. pneumoniae and other related bacteria are collectively termed Carbapenem Resistant Enterobacteriaceae (CRE). CDC Director Thomas Frieden has termed CRE "nightmare bacteria" because of high mortality from untreatable infections. 

In the following video, Drs. Michael Bachman and Rebekah Martin share their research on Klebsiella pneumoniae infections in hospital patients.