Jacqueline Mann of Nesvizhskii Lab Awarded NIH F31 Fellowship

By Elizabeth Walker | September 11 2017

Jacqueline Mann, an MCP Program PhD student in the lab of Alexey Nesvizhskii, PhD, has been awarded a Ruth L Kirschstein Predoctoral Individual National Research Service Award (F31) for her work with head and neck squamous cell carcinomas (HNSCCs).

Like many cancers, HNSCCs often employ immunosuppressive molecules to evade detection and clearance by the immune system. Thus, relieving immunosuppression represents an attractive therapeutic strategy. Jacqueline proposes to gain a detailed profile of the molecular pathways underlying immunosuppression in HNSCCs, seeking biomarkers and novel molecular targets to alter tumor immunogenicity. Ultimately, she aims to inform patient selection criteria and advance combination treatment protocols that alter tumor-immune system interactions.