Change in calibration of Direct Bilirubin Assay will lower results

By Donald Giacherio | December 16 2016



The manufacturer of the chemistry analyzers and reagents used here at UMHS (Siemens Healthineers, Tarrytown NY) has recently announced a change in its calibration material for the direct bilirubin assay in order to bring results more in line with a reference method. This change produces a significant proportional lowering of direct bilirubin results by approximately 30% at elevated direct bilirubin concentrations. There is very little change in lower values that are within the reference range for direct bilirubin. If trending a patient over time, please take this change into account.

The lab will be implementing the new calibration on December 20, 2016.
Please direct any questions concerning the change to Dr Don Giacherio at 936-6719 or email