Tomlins Lab

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Research in the Scott Tomlins lab utilizes integrative high-throughput approaches, including next generation sequencing, to molecularly profile genitourinary malignancies, including clinical subtyping of prostate cancer, as well as bladder and adrenocortical carcinoma.

My previous research has focused on using high-throughput techniques to characterize the cancer genome and transcriptome to identify cancer-specific aberrations to better understand cancer biology and identify clinically relevant biomarkers and therapeutic targets. My most important contribution has been discovering TMPRSS2:ETS gene fusions in prostate cancer, which play a fundamental role in prostate cancer development and have potential as biomarkers for early detection, risk stratification and therapeutic targeting. Through additional efforts, we have identified other molecular prostate cancer subtypes, which provide the foundation for improved classification, prognosis and personalized medicine.