Parkos & Nusrat Labs

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Welcome to the Parkos-Nusrat Group

Our laboratories have closely collaborated for over two decades. Our group investigates mechanisms regulating the intestinal barrier during health and disease, with particular focus on pathologic inflammatory states. We are interested in understanding fundamental mechanisms controlling epithelial homeostasis, which includes maintenance of barrier function through cellular migration, proliferation and repair, and how these processes are impacted in disease.

 

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Understanding the Barrier

Structure of the intestinal epithelium

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Defending the Barrier

Pathophysiology of barrier compromise

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Mobilizing Defenders of the Barrier

Leukocyte trafficking in mucosal inflammatory disease

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Rebuilding the Barrier

Molecular mechanisms of epithelial repair

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