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                          FACULTY MENTORS

 

Michael Bachman, M.D., Ph.D., Assistant Professor. The immune response to bacterial iron metabolism.

Stephen W. Chensue, M.D., Ph.D., Professor. Cellular and molecular mechanisms of leukocyte mobilization during granulomatous inflammation.

Arul Chinnaiyan, M.D., Ph.D., S.P. Hicks Endowed Professor of Pathology and Professor of Urology; Investigator, Howard Hughes Medical Institute. Prostate and Breast Cancer, Genomics, Proteomics, Metabolomics, and Bioinformatics.

Kathleen R. Cho, M.D., Professor. Molecular pathogenesis of gynecological tumors.

Tomasz Cierpicki, Ph.D., Assistant Professor. Structural studies of proteins involved in leukemogenesis. Development of small molecule compounds targeting protein-protein interactions relevant to leukemogenic transformation.

Yali Dou, Ph.D., Associate Professor. Epigenetic regulation by histone modifying enzymes in mammals.

Gregory Dressler, Ph.D., Professor. Genetic basis of cellular differentiation and pattern formation in a complex multicellular tissue.

Eric R. Fearon, M.D., Ph.D., Professor, Departments of Internal Medicine, Human Genetics, and Pathology. Tumor suppressor gene pathways in normal cell growth and differentiation, and the role of mutations in these pathways cancer.

David O. Ferguson, M.D., Ph.D., Associate Professor. DNA repair and genomic stability in mammals. Our focus is understanding how DNA repair prevents cancer through maintenance of genomic stability, and how it ensures proper development.

Jolanta Grembecka, Ph.D., Assistant Professor. Development of small molecules for targeted therapies in cancer, with a particular focus on proteins involved in leukemogenesis.

Cory Hogaboam, Ph.D., Professor. Chemokine contribution to chronic remodeling of the asthmatic airway in fungal asthma model.

Evan T. Keller, Ph.D. Professor. Immunologic aging.

Celina G. Kleer, M.D., Associate Professor. Genetic determinants of inflammatory breast cancer and the role of different markers as prognosticators in breast cancer.

Steven L. Kunkel, Ph.D., Endowed Professor in Pathology Research. Regulation of cytokine gene expression; macrophage pathobiology.

Elizabeth R. Lawlor, M.D., Ph.D., Russell G. Adderly Professor of Pediatric Oncology and Associate Professor of Pathology and Pediatrics. Pediatric cancer biology with a focus on Ewing sarcoma and stem cell pathway deregulation.

Andrew P. Lieberman, M.D., Ph.D. Associate Professor. Molecular mechanisms of neurodegeneration in polyglutamine expansion diseases and Niemann-Pick type C disease.

David B. Lombard, MD, PhD, Assistant Professor. Mammalian sirtuins in metabolism and aging; mechanisms of oxidative stress resistance.

Nicholas W. Lukacs, Ph.D., Professor. Cytokine/chemokine cascades associated with allergic airway responses (asthma) and T-lymphocyte-mediated pulmonary inflammation.

Richard A. Miller, M.D., Ph.D., Professor. Stress resistance pathways in long-lived mutant mice and long-lived species; and signal transduction in aging T cells.

Hedwig Murphy, M.D., Ph.D., Associate Professor. Endothelial cell responses in inflammation studied in cultured cells with emphasis on the enzyme source of endothelial cell oxidants, the role of endothelial cell derived oxidants in signaling and cell injury and the repertoire of endothelial cell derived cytokines and their role in inflammation.
Alexey Nesvizhskii, Ph.D., Assistant Professor. Functional and clinical proteomics, bioinformatics, computational analysis of biological datasets, mass spectrometry data analysis.

Zaneta Nikolovska-Coleska, PhD, Associate Professor. Discovery, design and development of small-molecules as new molecularly targeted therapies for cancer.
Gabriel Nuñez, M.D., Paul H. DeKruif Professor. Molecular regulation of programmed cell death (apoptosis), identification and characterization of apoptosis regulatory genes.

Jean-Francois Rual, Ph.D., Assistant Professor. Systems-level characterization of the Notch molecular network. Research interests lie in the field of systems biology and the use of proteomic approaches to study cellular networks. Focus on systematic analysis of protein interactions in biological systems and their relationship to human disease, with particular interest in the cancer-related Notch pathway. The Rual lab uses biochemical, molecular, cell biological, and genetic means in high-throughput settings to address these questions.

Sem H. Phan, M.D., Ph.D., Professor. Molecular and cellular mechanisms of tissue repair and fibrosis; regulation of extracellular matrix and cytokine gene expression; myofibroblast differentiation.

Lloyd M. Stoolman, M.D., Professor. Lymphocyte recirculation and migration; functional characterization of the lymphocyte and endothelial receptors that mediate migration into lymphoid organs and sites of chronic inflammation; role of lymphocyte homing receptors in the hematogenous dissemination of lymphoid malignancies; role of lymphocyte-extracellular matrix interactions in lymphocyte migration.

James Varani, Ph.D., Professor. Cell-substrate adhesion and cell motility in normal mammalian cells and their malignant counterparts; biosynthesis and surface expression of extracellular matrix molecules, such as fibronectin, laminin, and thrombospondin and their involvement as endogenous regulators of adhesion, motility, invasion, and metastasis.

Peter A. Ward, M.D., Godfrey D. Stobbe Professor. Mechanisms of the inflammatory response and its regulation; role of oxidants in tissue injury; mechanisms and participation of cytokines and chemokines; role of complement activation products in the inflammatory response.

Thomas E. Wilson, M.D., Ph.D., Associate Professor. Normal functions of DNA double-strand break (DSB) repair pathways and the origins of chromosomal rearrangements associated with cancer, specifically translocations, deletions, and amplifications.

Anuska V Andjelkovic-Zochowska, M.D., Ph.D. Associate Professor.
Molecular basis of inflammatory events at the blood brain barrier; the role of vascular endothelium in the pathogenesis of central nervous system inflammation; molecular mechanism of tumor associated angiogenesis.