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Analysis Reveals How Kidney Cancer Develops and Responds to Treatment
Not all kidney cancers behave the same, with wildly different responses to immunotherapy or other treatments – and wildly different outcomes for patients as a result. By sequencing the RNA of individual cells within multiple benign and cancerous kidney tumors, researchers from the University of Michigan Rogel Cancer Center have identified the cells [...]
Researchers Develop First-in-Class Inhibitors Against Key Leukemia Protein
A research effort by Drs. Jolanta Grembecka and Tomasz Cierpicki was just published in Nature Communications. Learn more about the protein made by the ASH1L gene, which plays a key role in the development of acute leukemia, along with other diseases [...]
Study Suggests Path to Blocking Common Genetic Driver of Lung Cancer
Stopping the interaction between KRAS and the protein AGO2 slowed tumor growth in mouse models.
Biomarker Could Help Identify Difficult-to-Diagnose Kidney Cancer Subtype
MiTF renal cell carcinoma can masquerade as other subtypes and may not respond as well to front-line therapies.
Study Explains Why Patients with Cancer Spread to the Liver Have Worse Outcomes
A new study by the University of Michigan's Rogel Cancer Center analyzed patients with cancer and the factors that cause the cancer to spread to the liver, leading to worse outcomes.
Prostate Cancer Regulator Plays Role in COVID-19, Providing a Promising Treatment Lead
Clinical trials underway are testing whether drugs that target the androgen receptor – successful in controlling prostate cancer – could also work against the coronavirus. wo proteins, ACE2 and TMPRSS2, help the coronavirus gain entry and replicate within cells. TMPRSS2 is well-known to Arul Chinnaiyan, MD, PhD. His lab discovered that TMPRSS2 fuses with the ETS gene to drive more than half of all prostate cancers [...]
Research Led by Drs. Cierpicki and Grembecka Published in "Blood"
A new study led by Drs. Jolanta Grembecka and Tomasz Cierpicki of the Department of Pathology was just published in Blood's American Society of Hematology. The research focuses on combinatorial treatment with menin and FLT3 and how inhibitors induce complete remission in acute myeloid leukemia (AML) with activating FLT3 mutations [...]
Dr. Celina Kleer Wins ASIP 2020 Outstanding Investigator Award
Congratulations to Dr. Celina Kleer who was awarded the American Society for Investigative Pathology (ASIP)'s 2020 Outstanding Investigator Award. Dr. Kleer receives the award for her demonstrated excellence in research in experimental pathology [...]
Scientists Develop First Drug-Like Compounds to Inhibit Elusive Cancer-Linked Enzymes
Structural biology techniques helped researchers target the nuclear receptor-binding SET domain family, whose malfunction is associated with several types of cancer.
Dr. Celina Kleer: Physician Scientist, Dedicated Mentor, ASIP Outstanding Investigator Awardee
Dr. Celina Kleer named 2019 AACR Outstanding Investigator in Breast Cancer Research
Dr. Udager Appears on '3Ps of Cancer' Podcast
Dr. Aaron Udager recently appeared on Michigan Medicine's 3P's of Cancer: Prevention, Preparedness, Progress podcast
Diagnostic Biomarkers Uncovered for Rare Kidney Cancer
Researchers have uncovered the gene signature for ChRCC.
Anti-Leukemia Compound Induces Complete Remission in Mouse Models
A Phase I clinical trial, using a structurally related analog of the compound, is currently enrolling patients.
A Simple Twist of Cell Fate
U-M researchers are shedding new light with exciting implications for research and health.
Kleer honored by the AACR
The American Association for Cancer Research announced that Celina Kleer, MD, the Harold A. Oberman Collegiate Professor of Pathology and Director of the Breast Pathology Program, will be the recipient of the 2019 Outstanding Investigator in Breast Cancer Research, supported by the Breast Cancer Research Foundation.
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