News Archive

/static/apps/cms/news/1281/images/banners/06082022_CSC_DermPath_Faculty_Photo-1405 x 600.png

Fun in the Sun...and Skin Cancer Risk

June 3, 2022 / Anatomic Pathology

What is skin cancer and how can you prevent it?

FULL STORY
/static/apps/cms/news/1216/Taylor_500x500.jpg

Research Study Published in European Urology's Open Science

January 5, 2022 / Faculty

 A multi-institutional study led by Drs. Alex Taylor, Noah Brown and Rohit Mehra from the Department of Pathology was just published in European Urology's Open Science. Learn more about the resarch, which focuses on how TERT promoter mutations were characterized in urinary tract lesions, which may be considered as precursors to neoplasia at this site [...]

FULL STORY
/static/apps/cms/news/1214/Cells-Microscopic-3D-Render-Particles-500x500.jpg

Study Demonstrates a Novel Approach to Target Enhancer-Addicted Cancers

January 4, 2022 / Mctp

A chromatin degrader stops transcription factors from driving cancer, which may serve as a potential treatment approach for over 90% of prostate cancers.

FULL STORY
/static/apps/cms/news/1180/Harms_500x500.jpg

The Link Between Dysplastic Squamous Cells and Merkel Cell Carcinoma (MCC)

October 15, 2021 / Clinical Pathology

Research pertaining to Merkel cell carcinoma (MCC) and cutaneous neuroendocrine carcinomas was just published in the latest edition of Modern Pathology. Led by the team of Drs. Paul Harms, May Chan, Aaron Udager, Rajiv Patel, and more [...]

FULL STORY
/static/apps/cms/news/1160/TRIM63-20x-500x500.jpg

TRIM63 - What is it? (Hint: Not a weight-loss product)

August 9, 2021 / Cancer

Dr. Xiao-Ming (Mindy) Wang and colleagues from the Michigan Center for Translational Pathology and Department of Pathology published a groundbreaking finding from an inter-institutional study regarding TRIM63 in Modern Pathology  [...]

FULL STORY
/static/apps/cms/news/1152/Green-Blob-Spirals-Blue-Molecule-500x500.jpg

Researchers Develop First Inhibitors Against Key Epigenetic Complex Involved in Cancer

June 21, 2021 / Leukemia

Activity of the polycomb repressive complex 1 is essential for the development and maintenance of leukemic cells; disrupting it presents a new potential therapeutic approach. Leukemia stem cells are rare cells that can renew themselves while continuing to generate malignant cells known as leukemic blasts. These cells are difficult to eradicate using chemotherapy drugs and frequently lead to recurrence of leukemia [...]

FULL STORY

Research Published in Urologic Oncology's ScienceDirect

June 10, 2021 / Cancer

Research by Drs. Alexander Taylor and Stephanie Skala seek to understand why tumors masquerade as forms of type-2 papillary of renal cell carcinoma. The study was just published in Urologic Oncology's ScienceDirect [...]

FULL STORY
/static/apps/cms/news/1147/Blue-Kidney-Cancer-Cell-500x500.jpg

Analysis Reveals How Kidney Cancer Develops and Responds to Treatment

June 10, 2021 / Mctp

Not all kidney cancers behave the same, with wildly different responses to immunotherapy or other treatments – and wildly different outcomes for patients as a result. By sequencing the RNA of individual cells within multiple benign and cancerous kidney tumors, researchers from the University of Michigan Rogel Cancer Center have identified the cells [...]

FULL STORY
/static/apps/cms/news/1136/Lab_Note_500x500.jpg

Researchers Develop First-in-Class Inhibitors Against Key Leukemia Protein

May 17, 2021 / Cancer

A research effort by Drs. Jolanta Grembecka and Tomasz Cierpicki was just published in Nature Communications. Learn more about the protein made by the ASH1L gene, which plays a key role in the development of acute leukemia, along with other diseases [...]

FULL STORY
/static/apps/cms/news/1134/Lung-Cell-Microscopic-Cancer-Purple-500x500.jpg

Study Suggests Path to Blocking Common Genetic Driver of Lung Cancer

May 12, 2021 / Mctp

Stopping the interaction between KRAS and the protein AGO2 slowed tumor growth in mouse models.

FULL STORY
/static/apps/cms/news/1122/Kidney-Cancer-Microscopic-Gene-Biomarker-500x500.jpg

Biomarker Could Help Identify Difficult-to-Diagnose Kidney Cancer Subtype

April 14, 2021 / Cancer Research

MiTF renal cell carcinoma can masquerade as other subtypes and may not respond as well to front-line therapies.

FULL STORY
https://www.pathology.med.umich.edu/static/apps/cms/1101/Harms_500x500.jpg

Prognostic Subgroups of Merkel Cell Carcinoma Defined

February 9, 2021 / Cancer

A collaboration between the Department of Pathology and the Department of Dermatology examined biomarkers of outcomes in 346 cases of Merkel cell carcinoma (MCC), an aggressive type of skin cancer. The study was published in the recent edition of Clinical Cancer Research [...]

FULL STORY

The multi-faceted role of the SUV family of H3K9 methyltransferases

February 8, 2021 / Clinical Pathology

A new study from Drs. Andrew Muntean and Nirmalya Saha of the Department of Pathology's Muntean Lab was just published in Biochim et Biophysica (BBA) Reviews on Cancer. The research project sheds light on the multi-faceted role of the SUV family of H3K9 methyltransferases in carcinogenesis and within cancer progression.

FULL STORY
https://www.pathology.med.umich.edu/static/apps/cms/1096/Udager_500x500.jpg

Research from Dr. Udager Published in European Urology

February 1, 2021 / Cancer

A new publication, generated by Department of Pathology faculty members Drs. Aaron Udager and Scott Tomlins was successfully published in European Urology. The research highlights a longitudinal cohort study centered around the serial molecular profiling of low-grade prostate cancer in order to better assess tumor upgrading [...]

FULL STORY
https://www.pathology.med.umich.edu/static/apps/cms/1087/Liver_Story_500x500.jpg

Study Explains Why Patients with Cancer Spread to the Liver Have Worse Outcomes

January 5, 2021 / Cancer

A new study by the University of Michigan's Rogel Cancer Center analyzed patients with cancer and the factors that cause the cancer to spread to the liver, leading to worse outcomes. 

FULL STORY
https://www.pathology.med.umich.edu/static/apps/cms/1080/GREMBECKA_500X500.jpg

Research Led by Drs. Cierpicki and Grembecka Published in "Blood"

December 2, 2020 / Cancer

A new study led by Drs. Jolanta Grembecka and Tomasz Cierpicki of the Department of Pathology was just published in Blood's American Society of Hematology. The research focuses on combinatorial treatment with menin and FLT3 and how inhibitors induce complete remission in acute myeloid leukemia (AML) with activating FLT3 mutations [...]

FULL STORY
https://www.pathology.med.umich.edu/static/apps/cms/1073/Myers_500x500.jpg

Global Virtual Cancer Conference: Dr. Jeffrey Myers

November 11, 2020 / Cancer

Introducing the 2020 Global Virtual Cancer Conference. Join us for the segment entitled "Prevention, Diagnosis and Me" to hear from the Department of Pathology's own Dr. Jeffrey Myers, who will discuss his experiences working in the cancer community [...]

FULL STORY
https://www.pathology.med.umich.edu/static/apps/cms/1048/500x500_MM_Image.jpg

Scientists Develop First Drug-Like Compounds to Inhibit Elusive Cancer-Linked Enzymes

September 2, 2020 / Rogel Cancer Center

Structural biology techniques helped researchers target the nuclear receptor-binding SET domain family, whose malfunction is associated with several types of cancer.

FULL STORY
https://www.pathology.med.umich.edu/static/apps/cms/1039/3Ps of Cancer Image.jpeg

Dr. Udager Appears on '3Ps of Cancer' Podcast

July 14, 2020 / Cancer

Dr. Aaron Udager recently appeared on Michigan Medicine's 3P's of Cancer: Prevention, Preparedness, Progress podcast

FULL STORY
https://www.pathology.med.umich.edu/static/apps/cms/1008/May_Chan_Story_Image.jpg

Research Regarding Microcystic Adnexal Carcinomas Published

June 11, 2020 / Cancer Research

The research was just published in Modern Pathology and highlights the importance of next-generation sequencing within oncogenic roles for P53 and JAK/STAT signaling in microcystic adnexal carcinomas.

FULL STORY

Study from Kleer and Nesvizhskii Labs Reveals the Proteomic Landscape of Metaplastic Breast Carcinomas

May 1, 2020 / Breast Cancer

Along with co-investigators, Sabra Djomehri, a graduate student in Celina Kleer's Laboratory, has discovered the proteomic landscape of metaplastic carcinomas, the most aggressive type of triple negative breast cancer. The study, published in [...]

FULL STORY
/static/apps/cms/news/956/Rohit-Header-LG-Apr14-2020.jpg

Diagnostic Biomarkers Uncovered for Rare Kidney Cancer

April 21, 2020 / Experimental Pathology

Researchers have uncovered the gene signature for ChRCC.

FULL STORY
/static/apps/cms/news/921/grembecka-921-Header-LG.jpg

Anti-Leukemia Compound Induces Complete Remission in Mouse Models

February 3, 2020 / Experimental Pathology

A Phase I clinical trial, using a structurally related analog of the compound, is currently enrolling patients.

FULL STORY

Cervical Health Awareness Month

January 24, 2020 / Anatomic Pathology

January is Cervical Health Awareness Month. While cervical health is important twelve months of the year, it’s a great time to schedule necessary appointments and screenings. According to Dr. Richard Lieberman, with regular health screenings and the use of pap-smear testing, death rates from cervical cancer have dropped 90% since 1943. [...]

FULL STORY
/static/apps/cms/news/896/Twist-of-Cell-Fate-896-Header-LG.jpg

A Simple Twist of Cell Fate

January 15, 2020 / Experimental Pathology

U-M researchers are shedding new light with exciting implications for research and health.

FULL STORY

PCR-based TERT Promoter Assays Aid in Bladder Cancer Diagnosis

October 30, 2019 / Publications

Our department's clinical resident Alex Taylor, MD, joined postdoctoral fellow Rahul Mannon, PhD, and other researchers from the Department of Pathology and the Michigan Center for Translational Pathology, who found that patients with a long-standing history of prostate cancer and other prostatic issues can find difficulty [...]

FULL STORY
/static/apps/cms/news/845/Betz-Passion-Art845-HeaderLG.jpg

A Fundamental Passion

October 18, 2019 / Insidepath

Bryan Betz, PhD, was inspired by his late wife, Sharon, to pursue a career in clinical diagnostics.

FULL STORY
/static/apps/cms/news/842/Cancer-Patients842-Header-LG.jpg

Cancer Patients Want to Pull Back the Curtain on Pathology

October 10, 2019 / Michigan Health Blog

Speaking directly with a pathologist could help patients better understand their diagnosis and feel empowered, a survey of patient sentiment finds.

FULL STORY
https://www.pathology.med.umich.edu/static/apps/cms/836/dad and sons 500 x 500 px.jpg

September is Prostate Cancer Awareness Month

September 17, 2019 / Cancer

Every year in the United States, nearly 3 million men hear the words, “You have prostate cancer.” That is 1 in 9 men each year.  The word “cancer” triggers an immediate response in most people…fear, worry about family, denial, and often an increased awareness of one’s mortality. [...]

FULL STORY
/static/apps/cms/news/830/MakingSense-Header-Lg.jpg

Making Sense Out of Tragedy

September 17, 2019 / Philanthropy

A gift from the Silver Family Foundation is funding research at Michigan Medicine.

FULL STORY

New Tool Helps Identify Patients at Risk for Hereditary Cancers

July 3, 2019 / Announcement

Lynn McCain and Drs. David Keren and Lee Schroeder are part of a multidisciplinary team at Michigan Medicine and Rogel Cancer Center who have developed an online tool to help identify those at risk for familial cancers. InheRET, which has already [...]

FULL STORY