Findings offer clues to why some types of renal cell carcinoma respond to immunotherapy while others do not — it’s a scientific riddle tangled up in a complex web. How do you turn an immune cold cancer into one that responds to immunotherapy?
The Department of Pathology's 2020 Annual Report is now available online. In the report, you will read about the department’s tripartite mission of research, education, and patient care, and learn about the goals of the department’s Strategic Council [...]
The Department of Pathology is pleased to announce its new Pathology Residency Training Program Leadership Team! Dr. Shih Hon (Sean) Li, will transition from Associate Residency Program Director to Residency Program Director, replacing Dr. Kristine Konopka, on August 1, 2021. Supporting him are Dr. David Manthei, who will serve as the Associate Residency Program Director for Clinical Pathology, and Dr. Sara Abbott [...]
Spanish is the second most frequently spoken language in the United States and at the University of Michigan Medical School, medical students are learning how to speak medical Spanish as they prepare to interact with their patients of the future. Whether the student is a beginner or fluent, they can participate in this program with the goal of being comfortable interacting with Spanish-speaking patients.
Within the Department of Pathology, lives a Communications Team who handle all aspects of departmental promotion. Led by Lynn McCain, the team also features Brent Temple, Camren Clouthier and Carrie Walper on the MLabs side. Learn more about this group of creative-minded individuals and how they help to put the Department on the map.
For the last 18 months, faculty and staff have had to endure the renovation being done in the hallways of the University Hospital, which caused significantly longer routes to deliver specimens, social separation from teammates, and the usual challenges associated with construction. However, on July 7, 2021, the walls came down and completed another milestone.
Activity of the polycomb repressive complex 1 is essential for the development and maintenance of leukemic cells; disrupting it presents a new potential therapeutic approach. Leukemia stem cells are rare cells that can renew themselves while continuing to generate malignant cells known as leukemic blasts. These cells are difficult to eradicate using chemotherapy drugs and frequently lead to recurrence of leukemia [...]
Research by Drs. Alexander Taylor and Stephanie Skala seek to understand why tumors masquerade as forms of type-2 papillary of renal cell carcinoma. The study was just published in Urologic Oncology's ScienceDirect [...]
Not all kidney cancers behave the same, with wildly different responses to immunotherapy or other treatments – and wildly different outcomes for patients as a result. By sequencing the RNA of individual cells within multiple benign and cancerous kidney tumors, researchers from the University of Michigan Rogel Cancer Center have identified the cells [...]
Research from the Department of Pathology was just published in the Archives of Pathology and Laboratory Medicine. Learn more about this publication, which highlights GI samples from COVID-19 patients, led by Dr. Maria Westerhoff [...]
A research effort by Drs. Jolanta Grembecka and Tomasz Cierpicki was just published in Nature Communications. Learn more about the protein made by the ASH1L gene, which plays a key role in the development of acute leukemia, along with other diseases [...]
Research from the Department's Lombard Lab was just published in the Journal of Clinical Investigation. The study, which focuses on how the deacylase SIRT5 compound supports melanoma viability by influencing chromatin dynamics, was led by Dr. Lombard [...]
Congratulations to Arul Chinnaiyan, MD, PhD, who was announced as the Science of Oncology Award and Lecture recipient by the American Society of Clinical Oncology (ASCO). As part of this award, Chinnaiyan will present a 30-minute lecture entitled “Exploring Precision Oncology: from Gene Fusions to Related Genetic Drivers“ at the ASCO Annual Meeting, to be held virtually on June 4-8, 2021 [...]
We are pleased to announced that Sriram Venneti, MD, PhD, Associate Professor of Neuropathology in the Department of Pathology with a joint appointment in Pediatrics, was appointed as the inaugural Al and Robert Glick Family Research Professor in Pediatrics, April 1, 2021. “Sriram has proven to be an exceptionally talented scientist, clinician, and colleague since joining us in 2014,” stated Dr. Charles Parkos, Chair of Pathology. “This is a well-deserved honor.” Please join us in congratulating him [...].
In 2009, a shy, but extremely talented employee arrived in the Education Office of the Department of Pathology. “From the beginning, we knew we’d work well together and since then, our team has become like family,” stated Marie Goldner about Pam Howard, the Residency Program Administrator. This week, the Education office bids Pam a fond farewell as she retires. “If I had to choose what I appreciate the most about Pam, it is her incredible commitment to her work. That is not something that can be easily taught. I think it is a characteristic inherent in who she is,” continued Goldner [...]
The department has navigated an unprecedented workload over the past year and continues to increase. Hear from experts Christine Kizer, Dr. Michael Bachman, Jennifer Bergendahl, and more, as they discuss how efforts have helped Michigan Medicine stay afloat during the COVID-19 pandemic [...]
As a member of Michigan Medicine, you have an opportunity to save lives by donating blood!
Three days of blood drives will be held on the medical campus:
A new publication from the Department of Pathology, led by Dr. Kathleen Cho, was just published in the American Association for Cancer Research's flagship journal. highlights how altering the microbiome within a mouse model of oviductal high-grade serious carcinoma can inhibit tumorigeneis [...]
Dr. Laura W. Lamps, the Godfrey Dorr Stobbe Professor and Director of Gastrointestinal Pathology and the director of the GI Pathology Fellowship Program, can now add President of the United States and Canadian Academy of Pathology (USCAP) to her list of titles. Dr. Lamps assumed this leadership role on April 1, 2021 [...]
MiTF renal cell carcinoma can masquerade as other subtypes and may not respond as well to front-line therapies.
This year's Medical Laboratory Professionals Week (MLPW) kicks off from April 18 until April 24, 2021. The department plans to celebrate with virtual events and activities for all those within the department! When did it start, and how can you be a part of it? Continue to the article for more information [...]
The Department of Pathology was well represented at the 110th Annual Meeting of the United States and Canadian Academy of Pathology (USCAP), held March 13-18, 2021. This year's event was reconstructed into a fully virtual format in response to the COVID-19 pandemic, with participants able to tune in and contribute from all over the world. Several of our faculty and trainees were featured at this year's conference. Let's take a moment to recap some key highlights from #USCAP2021.
Research by Drs. Ann Laszczyk and the Department of Pathology's Dr. Gregory Dressler was just published in the Journal of the American Society of Nephrology. The study focuses on PAX2 proteins and their effects on kidney function and development.
Giving Blueday, the University of Michigan’s 24-hour celebration of giving, has moved to the spring this year. On March 10, the university will encourage donors around the world to give to the programs and causes they care most about at U-M. Donors can visit the Giving Blueday website to find causes and make donations, view real-time progress, read about the impact of Giving Blueday, and more.
We encourage you to consider a gift to Pathology on Giving Blueday! [...]
Detroit's Daily Docket (D3), a podcast produced by Michigan Medicine forensic pathologists at the Wayne County Medical Examiner’s Office (WCMEO), launched its initial season in 2020. This successful podcast series is now gearing up to launch Season 2 on February 26, 2021.
The Department of Pathology bids a fond farewell to administrative assistant Ms. Linda O’Brien, who is set to retire from the Department at the end of February. Linda leaves the department with over 30 years of service, primarily working with the GI pathology faculty [...]
Research team discovered that proteins with the capacity to multimerize quickly responded to osmotic changes (dehydration) caused by high saline or sugar concentrations, condensing into aggregates resembling processing bodies (P-bodies). The reaction, known as hyperosmotic phase separation, or HOPS, takes only a few seconds and is reversible within less than 2 minutes [...]
The Annual Winter Blood Battle has begun! This year our opponent is Michigan State University. Our goal: To collect more pints of blood donated between February 10 and February 28, 2021 than MSU. All blood donors who register to donate as part of our U-M BB Team, will receive a Blood Battle T-shirt, a coupon for Washtenaw Dairy (while supplies last) and be entered into a raffle for gift cards to local business along with other great prizes. This is a win-win for you and the patients who receive your donated blood products. Let's make this a win-win-win as we beat MSU!
A series of sophisticated processes are required in the development of innate lymphoid cells (ILC) for them to reach maturity. The Kim laboratory discovered that basic leucine zipper ATF-like transcription factor (Batf) regulates the production of ILC progenitors in the bone marrow as well as the maintenance of ILCs in the periphery. These cells are strategically distributed in peripheral tissues to provide important innate immunity to fight pathogens such as pathogenic viruses and bacteria.
A collaboration between the Department of Pathology and the Department of Dermatology examined biomarkers of outcomes in 346 cases of Merkel cell carcinoma (MCC), an aggressive type of skin cancer. The study was published in the recent edition of Clinical Cancer Research [...]
Thursday, January 28th, was a bittersweet day for the Department of Pathology. Bill LeBar, Administrative Manager of the Clinical Microbiology Laboratory, retired after more than 12 years of service. A virtual retirement ceremony was held in his honor, with more than 50 faculty, staff, and family members attending [...]
The plethora of knowledge that pathology residents are expected to master – for future practice and especially for Boards – is overwhelmingly immense. Second-year resident, Dr. Ryan Landvater, has been working on a question bank software from scratch, in an effort to make the mastery of pathology knowledge less intimidating. Below is a short interview with Landvater, as well as screenshots of the QBank (beta version)...
A new publication, generated by Department of Pathology faculty members Drs. Aaron Udager and Scott Tomlins was successfully published in European Urology. The research highlights a longitudinal cohort study centered around the serial molecular profiling of low-grade prostate cancer in order to better assess tumor upgrading [...]
Dr. Chen Yang joined the faculty of the Michigan Medicine Departments of Pathology and Pediatrics in a joint recruitment effort in July 2020. He serves as the associate director of the Clinical Cytogenetics Lab (Pathology) and MMGL Molecular Genetics Lab (Pediatrics). Yang’s appointment is rather unique in that he has a 50% appointment in each department. Usually, faculty have a primary appointment in one department and a secondary “dry” appointment in another department.
Michael Caplan, MD is no stranger to the University of Michigan Department of Pathology. This is actually his fourth time joining the Department! After completing a BS in Criminalistics at Michigan State University and an MD from the University of Connecticut School of Medicine, Caplan joined the Department for the first time as an AP/CP Resident from 1987-1992.
Technological advances have made telepathology a reality for many pathologists, allowing challenging case consultations regardless of where the expert may be located. Recently, Dr. Liron Pantanowitz, Director of Anatomic Pathology, presented a keynote address entitled, "Telepathology: Still the #1 application of digital pathology" at the 7th Digital Pathology & AI Congress: Europe, December 1, 2020.
While in medical school, Dr. Myra Kahn discovered her love for gross pathology during a pathology rotation. This led her to a residency in Anatomic Pathology at the University of Chicago from 2014-2018. As a resident, Forensic Pathology “[put] together my interest for gross pathology along with autopsy,“ shared Khan. She also discovered her love for breast pathology [...]
A new study by the University of Michigan's Rogel Cancer Center analyzed patients with cancer and the factors that cause the cancer to spread to the liver, leading to worse outcomes.
Clinical trials underway are testing whether drugs that target the androgen receptor – successful in controlling prostate cancer – could also work against the coronavirus. wo proteins, ACE2 and TMPRSS2, help the coronavirus gain entry and replicate within cells. TMPRSS2 is well-known to Arul Chinnaiyan, MD, PhD. His lab discovered that TMPRSS2 fuses with the ETS gene to drive more than half of all prostate cancers [...]
Marie began her career at the University of Michigan as an undergraduate biology student working in security at the old Mott Hospital, checking ID badges. This is where she caught the attention of the phlebotomy supervisor, Theresa Malcolm, who encouraged Marie to contact her about a position in phlebotomy. Marie called and, as Marie recalls, “The rest is a 35-year history.”[...]
Recently, Department of Pathology faculty member Dr. Laura Lamps appeared on the December 3 episode of the PathPod Pocast's Beyond the Scope. In the episode, Dr. Lamps discusses a varierty of topics including her role as the Director of Gastrointestinal Pathology at Michigan Medicine, her involvement in United States and Canadian Academy of Pathology (USCAP), personal hobbies and her experience working in medicine overall [...]
Congratulations to Suzanne Butch for winning the American Association of Blood Banks’s 2020 President’s Award. This award was in recognition of her “extraordinary work with the ISBT Working Party on Information Technology and [her] leadership in moving the ISBT 128 labeling program forward.” [...]
A new study led by Drs. Jolanta Grembecka and Tomasz Cierpicki of the Department of Pathology was just published in Blood's American Society of Hematology. The research focuses on combinatorial treatment with menin and FLT3 and how inhibitors induce complete remission in acute myeloid leukemia (AML) with activating FLT3 mutations [...]
Congratulations to Dr. Thomas Giordano and the entire Cancer Genome Atlas Project team for winning the American Association of Cancer Research's 2020 Team Science Award [...]
New research by the Department of Pathology was recently published in Modern Pathology. The study, led by Drs. Aaron Udager, Noah Brown, Bryan Betz, Jonathan McHugh and Scott Tomlins, focuses on how TP53 mutations and CDKN2A mutations and deletions are highly recurrent molecular alterations within malignant progression of sinonasal papilomas [...]
Congratulations to Dr. Celina Kleer who was awarded the American Society for Investigative Pathology (ASIP)'s 2020 Outstanding Investigator Award. Dr. Kleer receives the award for her demonstrated excellence in research in experimental pathology [...]
Congratulations to Usha Kota, BS, MT(ASCP) on her retirement following 32 years in Pathology! Usha began in Pathology in 1988 in the blood bank, moving to flow cytometry in 1989. In 1990, she was promoted to senior technologist, then flow cytometry supervisor in 1994. In 2005, she was promoted to laboratory supervisor of Hematology [...]