News Archive

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What is a Research Lab Manager?

June 20, 2022 / Experimental Pathology

...and what do they do?

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Using Artificial Intelligence to predict ERG Gene Fusion in Prostate Cancer

May 10, 2022 / Experimental Pathology

The role of artificial intelligence (AI) in healthcare continues to expand. In a recent issue of BMC Cancer, Dr. Vipulkumar Dadhania (first author) and colleagues published a result of their study Leveraging artificial intelligence to predict ERG gene fusion status in prostate cancer. The expert team from the Michigan Center for Translational Pathology developed a deep-learning-based model to predict ERG genomic rearrangements in prostatic adenocarcinomas using only H&E-stained digital slides [...]

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Careers in Pathology: Aging Research

April 5, 2022 / Experimental Pathology

Dr. Richard Miller candidly describes his career progression in aging research.

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Parolia Selected For Harold Weintraub Graduate Student Award

March 1, 2022 / Experimental Pathology

Please join us in congratulating Dr. Abhijit Parolia on being selected for the 2022 Harold Weintraub Graduate Student Award. The award, established by the Fred Hutchinson Cancer Research Center, is given yearly and recognizes outstanding achievement during graduate studies in the biological sciences [...]

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Year in Review: 2021

January 31, 2022 / Conferences

Last year was an eventful time within the Department of Pathology at Michigan Medicine. As we reminisce about 2021, let's revisit some of the greatest memories [...]

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From Chaos to Balance

January 3, 2022 / Experimental Pathology

Dr. Anuska Andjelkovic-Zochowski's story

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The Yin and the Yang of Research in the COVID Era

December 20, 2021 / Newsletter

As COVID closed down research labs, researchers shifted focus.

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Study Finds that Microbiome Colonization During Infancy is Critical for Modulating Immunity Later in Life

October 29, 2021 / Experimental Pathology

A study related to the maternal gut microbiome and how it regulates immunity to respiratory syncytial virus (RSV) infections in offspring was recently published in the Journal of Experimental Medicine. Clinical experts from the Department of Pathology including Drs. Wendy Fonseca, Nicholas Lukacs, and Catherine Ptaschinski were responsible for carrying out this study [...]

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Repurposing an anti-diabetic drug to reverse aberrant epigenetic pathways in childhood ependymomas.

October 7, 2021 / Experimental Pathology

Metformin holds promise against a rare type of childhood brain tumor in laboratory studies, as per an international team of researchers led by Dr. Sriram Venneti report in Science Translational Medicine. [...]

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Dr. Peter A. Ward named “World Expert in Sepsis”

September 21, 2021 / Experimental Pathology

Dr. Peter Ward, Active Emeritus Professor and former Chair of Pathology, was named “World Expert in Sepsis” by Expertscape on World Sepsis Day, September 13, 2021. To be named a World Expert, one must be in the top 0.1% of scholars writing about Sepsis over the past ten years. Ward came in among the top .006% of scholars in the world and the number 1 scholar on sepsis at the University of Michigan [...]

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2020 Annual Report Now Available

August 3, 2021 / Experimental Pathology

The Department of Pathology's 2020 Annual Report is now available online. In the report, you will read about the department’s tripartite mission of research, education, and patient care, and learn about the goals of the department’s Strategic Council [...]

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Stressed Cellular Protein HOPS Into Action

February 16, 2021 / Experimental Pathology

Research team discovered that proteins with the capacity to multimerize quickly responded to osmotic changes (dehydration) caused by high saline or sugar concentrations, condensing into aggregates resembling processing bodies (P-bodies). The reaction, known as hyperosmotic phase separation, or HOPS, takes only a few seconds and is reversible within less than 2 minutes [...]

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Study Explains Why Patients with Cancer Spread to the Liver Have Worse Outcomes

January 5, 2021 / Experimental Pathology

A new study by the University of Michigan's Rogel Cancer Center analyzed patients with cancer and the factors that cause the cancer to spread to the liver, leading to worse outcomes. 

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Dr. Thomas Giordano wins the AACR 2020 Team Science Award

November 30, 2020 / Experimental Pathology

Congratulations to Dr. Thomas Giordano and the entire Cancer Genome Atlas Project team for winning the American Association of Cancer Research's 2020 Team Science Award [...]

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Dr. Celina Kleer Wins ASIP 2020 Outstanding Investigator Award

November 12, 2020 / Experimental Pathology

Congratulations to Dr. Celina Kleer who was awarded the American Society for Investigative Pathology (ASIP)'s 2020 Outstanding Investigator Award. Dr. Kleer receives the award for her demonstrated excellence in research in experimental pathology [...]

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Bad Bacteria Make Their Own Food to Colonize the Gut

October 16, 2020 / Experimental Pathology

Diarrhea can be the unfortunate but short-lived side effect of bad takeout food, yet it is also a leading cause of death in children under five globally. Scientists continue to investigate how illness-causing bacteria gain a foothold within the digestive tract when they are usually held in check by the protective bacteria collectively known as the gut microbiome [...]

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Study from Venneti Lab on DIPGs Published in Cancer Cell

August 17, 2020 / Experimental Pathology

In a new study, Chan Chung et al. from the Venneti laboratory have discovered a “catch 22”-like phenomena, where epigenetic and metabolic pathways feed one another, in a childhood brain tumor called Diffuse Intrinsic Pontine Gliomas (DIPG) [...]

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Research Surrounding H3K27M-mutant diffuse midline glioma in COVID-19 Published

July 7, 2020 / Experimental Pathology

New research related to H3K27M-mutant diffuse midline glioma with extensive intratumoral microthrombi in young adults with COVID-19 from the Department of Pathology was just published in Acta Neurologica. [...]

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Research Surrounding miR-181a Published

June 25, 2020 / Experimental Pathology

Research from Dr. Analisa Difeo was just published in Nature Communications. The study focuses on miR-181a and how it initiates and perpetuates oncogenic transformation through the regulation of innate immune signaling [...]

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Forensic Research Regarding COVID-19 Published

June 18, 2020 / Experimental Pathology

The publication takes an in-depth examination of diffuse alveolar damage (DAD) caused by COVID-19 and how it is morphologically indistinguishable from other causes of DAD.

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Research Regarding Microcystic Adnexal Carcinomas Published

June 11, 2020 / Experimental Pathology

The research was just published in Modern Pathology and highlights the importance of next-generation sequencing within oncogenic roles for P53 and JAK/STAT signaling in microcystic adnexal carcinomas.

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U-M Researchers Home in on Key Player in Pancreatic Cancer Development

June 4, 2020 / Experimental Pathology

The protein Argonaute 2 was found to be critical to the progression from benign lesions into pancreatic cancer, suggesting a therapeutic opportunity.

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Research Regarding Invasive Squamous Cell Carcinoma Published

May 29, 2020 / Experimental Pathology

The research, which focuses on invasive squamous cell carcinomas and the precursor lesions that demonstrate concordic genomic complexity in driver genes, was just published in Modern Pathology.

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Research about Renal Cell Carcinoma in Young Adults Published

May 22, 2020 / Experimental Pathology

The research was just published in Histopathology and features prominent contributions from our faculty.

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2019 Annual Report Now Available

May 19, 2020 / Experimental Pathology

The Department of Pathology 2019 Annual Report is now available online. Our department continues to show outstanding performance and growth and the past year was another example of why our department is one of the best in the world.

In the report, you will read about [...]

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New Research Published in Modern Pathology

May 13, 2020 / Experimental Pathology

The study pertains to the molecular characterization of uterine and ovarian tumors and their relationships to epithelial and germ cell features by somatic derivation.

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New Research Published in Journal of Lower Genital Tract Disease

May 7, 2020 / Experimental Pathology

The study sheds light on alternative methods used for measuring size and depth of vulvar squamous cell carcinoma.

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Study from Kleer and Nesvizhskii Labs Reveals the Proteomic Landscape of Metaplastic Breast Carcinomas

May 1, 2020 / Experimental Pathology

Along with co-investigators, Sabra Djomehri, a graduate student in Celina Kleer's Laboratory, has discovered the proteomic landscape of metaplastic carcinomas, the most aggressive type of triple negative breast cancer. The study, published in [...]

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Arul Chinnaiyan, MD, PhD, elected to the National Academy of Science

April 28, 2020 / Experimental Pathology

Congratulations to Arul M. Chinnaiyan, MD, PhD, on his election to the National Academy of Science!  Chinnaiyan is an investigator, Howard Hughes Medical Institute; and S.P. Hicks Endowed Professor of Pathology, American Cancer Society Research Professor, and director, Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor [...]

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Study from Lieberman Lab Published in Acta Neuropathologica

April 28, 2020 / Experimental Pathology
 

A new study from the Andrew Lieberman Laboratory’s Samir Nath, et al, has discovered that MEF2 impairment underlies skeletal muscle atrophy in polyglutamine disease.

Kennedy’s Disease, also known as Spinal and Bulbar Muscular Atrophy (SBMA), is a disease caused by an inherited gene mutation that results in muscle and brain cell dysfunction. Patients progressively lose muscle mass until they are unable to walk without assistance. Ultimately [...]

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Diagnostic Biomarkers Uncovered for Rare Kidney Cancer

April 21, 2020 / Experimental Pathology

Researchers have uncovered the gene signature for ChRCC.

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New Study Discusses Viral Transportation in COVID-19 Pandemic

April 20, 2020 / Experimental Pathology

A new study from Dr. Rajan Dewar of the Department of Pathology has found that inactivated virus transporation should be implemented for safe transportation and handling at diagnostics laboratories.

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New Study Finds Inhibition of Uric Acid or IL-1β Ameliorates Respiratory Syncytial Virus Immunopathology and Development of Asthma

April 15, 2020 / Experimental Pathology

The study details research surrounding Respiratory Syncytial Virus (RSV) among infants.

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New Study Finds Resolvin E1 is a Pro-repair Molecule that Promotes Intestinal Epithelial Wound Healing

April 14, 2020 / Experimental Pathology

Resolvin E1 (RvE1), a lipid derived from Omega-3 fatty acids, is a pro-repair molecule that promotes healing of intestinal wounds according to a recent study published in PNAS as a collaborative project between The Department of Pathology at the University of Michigan Medical School and [...]

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Department Co-Hosts 2020 Mucosal Immunology Symposium

March 13, 2020 / Conferences

The event showcased experiemental pathology research.

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Marcin Cieslik Receives Award from Bristol-Myers Squibb

March 11, 2020 / Experimental Pathology

Marcin Cieslik, Assistant Professor of Pathology and Computational Medicine and Bioinformatics and member of the Michigan Center for Translational Pathology (MCTP), received an award from Bristol-Myers Squibb (BMS) for the project entitled, “Identification of novel therapeutic vulnerabilities across immunophenotypes of refractory and metastatic tumors.” This award provides two years of funding.

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Department Hosts 11th Annual CHAMP Research Symposium

February 17, 2020 / Conferences

Event showcases clinical and translational research.

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New Start Up Aims to Target Inflammatory Bowel Disease

February 17, 2020 / Experimental Pathology

PTM Therapeutics, Inc. celebrated on February 6th the signing of an exclusive license for an antibody (PTM-001) jointly from the University of Michigan and Emory University during a bell-ringing ceremony at University of Michigan Tech Transfer. The startup is [...]

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Manuscript by Dr. Muhammad Nadeem Aslam Demonstrates Effects of a Seaweed-Derived Multi-Mineral Supplement on Colonic Microbial Community

February 5, 2020 / Experimental Pathology

A recent report based on a phase I clinical trial by Dr. Aslam, et al, in the Varani Laboratory shows that a multi-mineral supplement, Aquamin®, modulates the colonic microbial community in human subjects.  This study is part of an ongoing effort to determine if multi-mineral intervention [...]

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Anti-Leukemia Compound Induces Complete Remission in Mouse Models

February 3, 2020 / Experimental Pathology

A Phase I clinical trial, using a structurally related analog of the compound, is currently enrolling patients.

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A Simple Twist of Cell Fate

January 15, 2020 / Experimental Pathology

U-M researchers are shedding new light with exciting implications for research and health.

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Dr. Chan Chung Receives Two Grants to Study Brain Cancers

January 9, 2020 / Experimental Pathology
 

Chan Chung, PhD, received two grants in funding from the ChadTough Foundation and Defeat DIPG foundation ($150,000) and the Robert Connor Dawes CERN Pediatric Fellowship ($100,000). [...]

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Faculty Spotlight: Felipe da Veiga Leprevost, PhD

January 2, 2020 / Experimental Pathology

In 2015, Felipe da Veiga Leprevost, PhD, came to the University of Michigan as a research fellow to study computational proteomics. In June of 2019, he accepted a faculty position as a Research Investigator in Bioinformatics. He now has a Michigan-born little one and his roots are growing deeper in Ann Arbor [...]

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ORSP's New Proposal Submission Deadline Policy

December 11, 2019 / Experimental Pathology

For future grant submissions, please take note of  ORSP's new Proposal Submission Deadline Policy which will take effect on January 6, 2020. [...]

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Gabriel Nuñez, M.D. Elected to the National Academy of Medicine

October 21, 2019 / Experimental Pathology

Dr. Gabriel Nuñez, the Paul de Kruif Endowed Professor of Pathology, is one of the newest members of the National Academy of Medicine. The Nuñez laboratory has made ground-breaking discoveries in the field of [...]

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Steven L. Kunkel, PhD, Appointed Permanent Executive Vice Dean for Research and Chief Scientific Officer

September 26, 2019 / Experimental Pathology

Congratulations to Steven L. Kunkel, PhD, on his appointment as the executive vice dean for research and chief scientific officer of the University of Michigan Medical School, effective September 1, 2019, following a nationwide search for the best candidate.  Kunkel previously served [...]

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Dr. Surinder Kumar Receives The Pablove Foundation Childhood Cancer Research Grant

September 18, 2019 / Experimental Pathology

Surinder Kumar, Ph.D., has received The Pablove Foundation Childhood Cancer Research Grant for his proposal entitled “The sirtuin SIRT5 as a novel therapeutic target for Ewing’s Sarcoma” [...]

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Making Sense Out of Tragedy

September 17, 2019 / Experimental Pathology

A gift from the Silver Family Foundation is funding research at Michigan Medicine.

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September is Prostate Cancer Awareness Month

September 17, 2019 / Experimental Pathology

Every year in the United States, nearly 3 million men hear the words, “You have prostate cancer.” That is 1 in 9 men each year.  The word “cancer” triggers an immediate response in most people…fear, worry about family, denial, and often an increased awareness of one’s mortality. [...]

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Raising the Voices of Pathology Postdocs

September 13, 2019 / Experimental Pathology

In November 2018, postdoctoral fellow Jay Vornhagen, PhD, was appointed as the first Department of Pathology Medical School Postdoctoral Trainee Senator.  The Medical School Postdoctoral Trainee Senate is a volunteer organization [...]

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Navigating Change

September 9, 2019 / Experimental Pathology

The Department of Pathology embraces the future while navigating through multiple changes as it settles into its new laboratory home.

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By Cannibalizing Nearby Stromal Stem Cells, Some Breast Cancer Cells Gain Invasion Advantage

July 2, 2019 / Experimental Pathology

Cancer biologists and engineers collaborated on a device that could help predict the likelihood of breast cancer metastasis.

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Newly Defined Cancer Driver is Fast, Furious, and Loud

June 19, 2019 / Experimental Pathology

Researchers characterize 3 ways in which the gene FOXA1 mutates to trigger prostate cancer.

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Jolanta Grembecka, PhD, Among 14 Inaugural Rogel Scholars

May 14, 2019 / Experimental Pathology

Congratulations to Jolanta Gembecka, PhD, who is one of fourteen in the inaugural class of Rogel Scholars!  As part of the commitment from Richard and Susan Rogel, researchers will have the opportunity and freedom to pursue new directions in their work. Dr. Grembecka's research focus is developing [...]

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U-M Compounds Show Promise in a Lab Model of Advanced Prostate Cancer

May 14, 2019 / Experimental Pathology

A new study finds that U-M-designed compounds led to significantly smaller, slower-growing tumors.

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Researchers Find New Target to Improve Response to Cancer Immunotherapy

May 8, 2019 / Experimental Pathology

A U-M study is the first to define how a little-known type of cell death impacts tumor cells and immune cells.

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Department Among Leadership, Award Winners, at ASIP Annual Meeting

April 17, 2019 / Experimental Pathology

The Department of Pathology was well-represented at the American Society for Investigative Pathology’s 2019 Annual Meeting.

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Dr. Charles Parkos Inducted into Association of American Physicians

April 7, 2019 / Experimental Pathology

Dr. Charles Parkos, Carl V. Weller Professor and Chair of the Department of Pathology, has been inducted into the Association of American Physicians (AAP). Founded in 1885, the AAP is an organization of leading senior physician-scientists [...]

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Witnessing the dance of RNAs around droplets of cellular degradation machinery

April 3, 2019 / Experimental Pathology

If a picture's worth a thousand words, a video is perhaps worth much more.

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Glover and Fearon Honored for AAAS Fellowships at Annual Meeting

February 18, 2019 / Experimental Pathology

Eric Fearon, MD, PhD , and Thomas Glover, PhD, are two of fifteen researchers at the University of Michigan named 2018 American Association for the Advancement of Science (AAAS) Fellows. A total of 416 members were awarded for 2018, chosen by their peers for their [...]

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Creating Hope

February 18, 2019 / Experimental Pathology

Mark Schultz, PhD strives to create therapeutics for Niemann-Pick disease.

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Circular RNA Holds Promise as Cancer Biomarker

February 7, 2019 / Experimental Pathology

Unique structure of circRNA makes it an ideal candidate for biomarkers – and it can be detected in blood or urine.

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Kathleen Cho, MD, Receives R01 Grant for Ovarian Cancer Research

January 9, 2019 / Experimental Pathology

Dr. Kathleen Cho received a five-year R01 grant from the National Institutes of Health (NIH) to continue her work in ovarian cancer research. High-grade serous carcinoma, or HGSC, is both the most common and most deadly form of “ovarian” cancer, although it is now believed that most HGSCs arise [...]

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Tomasz Cierpicki Awarded NIH Research Project Grant

December 11, 2018 / Experimental Pathology

Tomasz Cierpicki, PhD, has been awarded an RO1 with five years of funding from the National Cancer Institute for his grant application, Targeting NSD1 In Leukemia, to develop inhibitors of NSD1 histone [...]

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Jiaqi Shi Awarded Grant from the National Cancer Institute

December 11, 2018 / Experimental Pathology

Jiaqi Shi, MD, PhD, has been awarded a KO8 (Career Development Award) from the National Cancer Institute for her grant application, Linking epigenetic regulation and TGF-β signaling in [...]

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Russell Ryan, MD receives ASH Junior Faculty Scholar Award

December 10, 2018 / Experimental Pathology

The American Society of Hematology (ASH) has chosen Dr. Russell Ryan as a recipient of its Junior Faculty Scholar Award in Basic/Translational Research. Established more than 30 years ago, the Scholar Awards program is one of [...]

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Discovery out of Nikolovska-Coleska Lab featured at Celebrate Invention

November 20, 2018 / Experimental Pathology

Dr. Zaneta Nikolovska-Coleska’s work was highlighted as part of the Featured Technology and Startup Kiosks during the University of Michigan Tech Transfer’s annual Celebrate Invention event on October 17th at the Michigan League. Nikolovska-Coleska’s project, Discovery of Mc1-1 inhibitors from integrated [...]

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Dr. Jeffrey Hodgin awarded U-M Precision Health Investigator Grant

November 6, 2018 / Experimental Pathology

Precision Health at the University of Michigan has chosen Dr. Jeffrey Hodgin as one of ten recipients of its Investigators Awards. The grants, totaling nearly $3 million, are of up to $300,000 each [...]

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Jim Harbaugh meets with scientists at Michigan Stadium

October 30, 2018 / Experimental Pathology
 

On Sunday, October 21, Jim Harbaugh, head coach of University of Michigan football, greeted 125 surprised attendees of the Pathology Investigators, Students and Academicians (PISA) Conference being hosted by the University of Michigan at the A. Alfred Taubman Biomedical Science Research Building in Ann Arbor. PISA attendees [...]

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Team Led by Dr. Rohit Mehra discovers New Diagnostic Biomarker for Kidney Cancer

October 11, 2018 / Experimental Pathology

A recent collaborative study out of the Michigan Center for Translational Pathology (MCTP) has led to new insight into kidney cancer. The resulting paper, VSTM2A Overexpression is a Sensitive and Specific Biomarker for [...]

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Careers in Pathology: Dr. Taeko Noah

October 10, 2018 / Experimental Pathology

In this episode of Careers in Pathology, Dr. Taeko Noah talks about her work in the Hogan Lab researching food allergies. Dr. Noah is a cellular biologist working as a Research Scientist in Pathology, studying how food crosses the intestinal epithelium to trigger allergic reactions.

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Dr. Udager receives Grant from U-M Prostate SPORE

October 9, 2018 / Experimental Pathology

The University of Michigan SPORE in Prostate Cancer has awarded Aaron Udager, MD, PhD, with a two-year Prostate SPORE Career Enhancement Program (CEP) grant of $60,00 per year. The Department of Pathology will contribute matching funds of another [...]

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Research from the Kim Lab published in Nature Communications

October 4, 2018 / Experimental Pathology

The laboratory of Dr. Chang Kim, along with colleagues from Purdue University and the Indiana University School of Medicine, has published in Nature [...]

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New Mechanism in Aggressive Breast Cancer Discovered

October 3, 2018 / Experimental Pathology

A collaboration out of the Molecular and Cellular Pathology graduate program could lead to new treatment strategies.

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Stories Found in Tissues

September 17, 2018 / Experimental Pathology

Simon Hogan, PhD, unlocks the Secrets of Allergic Diseases.

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U-M cancer researcher awarded $6.5M Outstanding Investigator Award to explore precision oncology

September 11, 2018 / Experimental Pathology

Funding to Chinnaiyan supports evaluating new cancer markers that could become treatment targets.

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She Designed a Life She Loves

August 27, 2018 / Newsletter

The story of how Kathleen R. Cho, MD, created a career in which she excels at diagnostics, research, and administration.

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Fall Orientation for Clinical Investigators

August 16, 2018 / Experimental Pathology

8:00 am – 11:30 am |  University Hospital Room UH 2C224

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Researchpalooza

August 8, 2018 / Experimental Pathology

11:00 am – 2:00 pm | Med Sci I Circle Drive

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Asking Tough Questions

July 31, 2018 / Experimental Pathology

Triple-negative breast cancers account for just 15-20% of breast cancers, but a disproportionate number of deaths. A Nature Communications paper from the Kleer Lab, in close collaboration with other U-M Department of Pathology labs, has discovered a reason why and could lead to better outcomes for patients.

Celina Kleer, MD’s lab in the Rogel Cancer Center is occupied by staff and students with a range of experiences and talents, but a common goal – understanding difficult breast cancers [...] 

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Dr. Giordano Published in Endocrine-Related Cancer

July 18, 2018 / Experimental Pathology

Thomas Giordano, MD, PhD, the Henry Clay Bryant Professor of Pathology, has published an invited review article in a special issue of Endocrine-Related Cancer, celebrating 65 years of the double helix. In Classification of endocrine tumors in the age of integrated genomics, Giordano shares [...]

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Dr. Asma Nusrat elected President of the American Society for Investigative Pathology

July 16, 2018 / Experimental Pathology

Congratulations to Asma Nusrat, MD, the Aldred Scott Warthin Professor and director of experimental pathology in the Michigan Medicine Department of Pathology, for her election as president of the American Society for Pathology for [...]

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Dr. Gabriel Nuñez selected for the 2019 Rous-Whipple Award from the American Society for Investigative Pathology

July 16, 2018 / Experimental Pathology

Dr. Gabriel Nuñez, the Paul de Kruif Endowed Professor of Inflammation & Immunology and Co-Director of Immunology and Host Response Program in the Michigan Medicine Department of Pathology, has been [...]

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Dr. Steven L. Kunkel Appointed as Distinguished University Professor

July 2, 2018 / Experimental Pathology

Congratulations to Dean Steven Kunkel on his appointment as Distinguished University Professor, one of the University of Michigan's highest honors, and being recognized for his exceptional achievements and services.  He was one of five professors honored this year, effective September 1, 2018. 

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Philip Giesen Award and Lecture Highlights Pathology’s Commitment to Supporting Trainee Research

June 28, 2018 / Experimental Pathology

A life insurance policy purchased in the seventies is being used to recognize resident achievement today.

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Dr. Nick Lukacs selected for the 2018 MICHR Distinguished Mentorship Award

June 26, 2018 / Experimental Pathology

Congratulations to Dr. Nick Lukacs, the Godfrey D. Stobbe Professor of Pathology, Assistant Dean for Faculty Affairs and the Scientific Director of the Mary H. Weiser Food Allergy Center, for his nomination and selection for the 2018 MICHR Distinguished Mentorship Award!

Lukacs was nominated by his trainees and peers at the [...]

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Celina G. Kleer, MD selected for the 2018 MICHR Distinguished Clinical and Translational Research Mentor Award

June 18, 2018 / Experimental Pathology

Congratulations to Dr. Celina Kleer, the Harold A. Oberman Collegiate Professor of Pathology, who has been selected as the 2018 recipient of the 7th Annual MICHR Distinguished Clinical and Translational Research Mentor Award!

Dr. Kleer was nominated by her trainees as well as peers at U-M Medical [...]

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Department Co-Hosting the 2018 PISA Conference

June 14, 2018 / Conferences

The Department of Pathology and the American Society for Investigative Pathology (ASIP) are proud to host the interactive, abstract-driven 2018 Pathobiology for Investigators, Students and Academicians Conference (PISA), in Ann Arbor, Michigan on October 20-22 [...]

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Genome's Dark Matter Sheds Light on Prostate Cancer Challenge

June 1, 2018 / Experimental Pathology

Researchers identify a lncRNA that provides insight into a key driver of prostate cancer — and a potential target for future therapy.

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MCP Students Take Top Prizes at 4th Annual Midwest Case Competition

April 11, 2018 / Experimental Pathology

Molecular and Celluar Pathology (MCP) Students Siva Kumar Natarajan, Paloma Garcia, and Kelly Kennaley took earned valuable experience and took top prizes during the 4th Annual Midwest Case Competition.

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Join Us in Congratulating Emmalee Adelman, PhD

April 10, 2018 / Experimental Pathology
 

Molecular and Cellular Pathology Graduate Program student, Emmalee Adelman, successfully defended her PhD thesis on April 9. Widespread epigenetic reprogramming in aging human hematopoietic stem cells, covers her work [...]

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How The Cancer Genome Atlas Will Shape the Future of Cancer Research

April 5, 2018 / Experimental Pathology

A decade-long effort to genomically characterize multiple cancers begets a huge archive.

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Chinnaiyan and Mehra Contribute to Paper on PD-L1 Expression

April 3, 2018 / Experimental Pathology

Arul Chinnaiyan, MD, PhD and Rohit Mehra, MD are contributing authors of a new paper, Comprehensive evaluation of PD-L1 expression in primary and metastatic prostate cancer, published in The American Journal of [...]

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New Gastrointestinal Pathologist Strives for Excellence and Joie De Vivre

March 26, 2018 / Experimental Pathology

The desire to propel her research has brought Maria Westerhoff, MD to the University of Michigan

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Women’s History Month - Ruth C. Wanstrom, MD

March 26, 2018 / Experimental Pathology

Highlighting one of the first female University of Michigan Department of Pathology faculty.

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World TB Day – Wanted: Leaders for a TB-Free World

March 23, 2018 / Experimental Pathology

Pathology's involvement in tuberculosis research and diagnosis

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Improving Trauma Survival Hinges on the Body's Own First Responders

March 19, 2018 / Experimental Pathology

Recent discoveries about how the immune system reacts to injury — and the dire consequences
if that response spirals out of control — could help improve trauma care

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Dr. Parkos Visits Capitol Hill to Advocate for Increased Research Funding

March 14, 2018 / Experimental Pathology

Dr. Charles Parkos was part of a delegation representing the Federation of American Societies for Experimental Biology (FASEB) on March 8, 2018 in Washington, D.C. to advocate for increased funding for research[...]

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Richard Miller, MD, PhD Elected Into Association of American Physicians

March 7, 2018 / Experimental Pathology

Richard Miller MD, PhD, has been elected into the Association of American Physicians (AAP). The AAP is a non-profit, professional organization founded in 1885 for “the advancement of scientific and practical medicine.” The Association is composed of members who are leading senior physician-scientists and are [...]

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DIPG Tumor Patterns Offer New Insight on Survival

January 22, 2018 / Experimental Pathology
An analysis of several hundred DIPG and related tumors, including of Chad Carr,
finds an overlooked key factor in determining prognosis
for the aggressive childhood brain cancer.
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Modern Pathology Cover Features Research by Mehra, Skala, and Team

January 10, 2018 / Experimental Pathology

Clinical FISH Assays for TFE3 and TFEB Help Characterize Renal Cell Carcinoma.

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Andrew Lieberman, MD, PhD Elected to National Neuropathology Core Steering Committee

December 19, 2017 / Experimental Pathology

Andrew Lieberman, MD, PhD, Gerald D. Abrams Collegiate Professor and Director of Neuropathology, has been elected to serve on the Neuropathology Core Steering Committee of the National Alzheimer’s Coordinating Center (NACC). The goal of the [...]

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Dr. Sriram Venneti Receives Sontag Foundation Distinguished Scientist Award

November 3, 2017 / Experimental Pathology
Sriram Venetti. MD, PhD, was awarded a $600,000 Sontag Foundation Distinguished Scientist Award grant over a period of 4 years to support his research in cancer metabolism and epigenetics in childhood ependymomas [...]
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Nusrat Lab and Collaborators Publish on Human Intestinal Organoid Generation in Nature Cell Biology

October 24, 2017 / Experimental Pathology
 
Miguel Quiros, Dorothee Siuda, Vicky Garcia-Hernandez in the laboratory of Asma Nusrat in our Department of Pathology, along with collaborators in the Michigan Medicine Departments of Internal Medicine, Cell and Developmental Biology and Center for Organogenesis, and colleagues from [...]
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Study by Russell Ryan and Colleagues Links Mutations in Notch Gene to Role in B Cell Cancers

October 24, 2017 / Experimental Pathology
Notch is one of the most frequently mutated genes in chronic lymphocytic leukemia (CLL), the most common leukemia in adults in the United States. It is also often mutated in other common B cell tumors, such [...]
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Michael Garratt, PhD, Receives $50,000 AFAR Research Grant for Junior Faculty

October 20, 2017 / Experimental Pathology
Michael Garratt, PhD, Assistant Professor of Genetics and Aging in the Department of Pathology, has received a $50,000 Research Grant from the American Federation for Aging Research (AFAR). Founded in 1981, AFAR [...]
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Rual Lab Publishes in The EMBO Journal

October 19, 2017 / Experimental Pathology
 
 
A team led by Drs. Tao Xu and Sung-Soo Park in the Jean-Francois Rual Lab shows that the methyl‐lysine reader L3MBTL3 switches the Notch coactivator RBPJ to a [...]
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Nisha D'Silva, PhD Awarded 8.1M Grant for Cancer Research

October 5, 2017 / Experimental Pathology
Head and neck cancer is the sixth-most common cancer in the world. Nisha D'Silva, PhD has received a Sustaining Outstanding Achievement in Research, or SOAR, award [...]
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Free Translational Research Symposium on October 4

September 21, 2017 / Conferences
The leaders and victors at University of Michigan are redefining translation, extending the definition far beyond the fields of health and biomedicine. Join translational experts for Found in Translation: Moving Beyond Biomedical Research, the 2017 Translational Research Symposium.

Hear about the future of translational research from keynote speaker, Christopher P. Austin, MD, Director of the National Center for Advancing Translational Sciences at the National Institutes of Health. You'll learn [...]
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Fight Food Allergies at FARE’s Food Allergy Heroes Walk

September 19, 2017 / Experimental Pathology
1 in 13 children has a food allergy. The Mary H. Weiser Food Allergy Center’s mission is to improve the lives of food allergic individuals by conducting comprehensive food-allergy-related research that will significantly improve patient care and expand food allergy education, research, and community services [...]
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PhD Student, Paloma Garcia, Awarded F31 Fellowship

September 11, 2017 / Experimental Pathology
 
Paloma Garcia, a PhD student in the Dr. Gabriel Nunez Lab, has been awarded an F31 Fellowship. The Ruth L. Kirschstein National Research Service Award Individual [...]
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Jacqueline Mann of Nesvizhskii Lab Awarded NIH F31 Fellowship

September 11, 2017 / Experimental Pathology
 
Jacqueline Mann, an MCP Program PhD student in the lab of Alexey Nesvizhskii, PhD, has been awarded a Ruth L Kirschstein Predoctoral Individual National Research Service Award (F31) for her work with head and neck squamous cell carcinomas (HNSCCs) [...]
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Nick Lukacs, PhD Named President-Elect of Society for Leukocyte Biology

September 6, 2017 / Experimental Pathology
The members of the Society for Leukocyte Biology (SLB) have chosen Nick Lukacs, PhD as their President-Elect. Dr. Lukacs is the Godfrey Dorr Stobbe Professor of Pathology and Assistant Dean for Faculty Affairs. He's also the Scientific Director [...]
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Chinnaiyan Lab PhD Students Receive Department of Defense Awards

August 30, 2017 / Experimental Pathology
 
 
Abhijit Parolia and Yajia Zhang, both MCP students in the laboratory of Dr. Arul Chinnaiyan, have each been awarded Department of Defense awards for prostate cancer research [...]
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Paper from Dressler Lab Shows Inhibition of Pax2 Transcription Activation

August 29, 2017 / Experimental Pathology
 
A paper published in ACS Chemical Biology by Edward Grimley, PhD, et al in Dr. Greg Dressler’s lab demonstrates the ability to target a DNA binding domain of the Pax gene family with small molecules [...]
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Research from the Chinnaiyan Lab on the Cover of Nature

August 29, 2017 / Experimental Pathology
 
In one of the largest and most comprehensive efforts to examine the genetic and molecular landscape of advanced cancer, Dr. Dan Robinson, et al in Dr. Arul Chinnaiyan's laboratory in the Department of Pathology sequenced the DNA and RNA of 500 patients with metastatic cancer. The results are [...]
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Michigan Legacy Tissue Program to Expand Patient Contribution and Clinical Research

August 15, 2017 / Experimental Pathology
 
Under the Direction of Dr. Rohit Mehra, of Pathology, and Dr. Ajjai Alva, of Medical Oncology, the Rapid Autopsy Program has been expanded and renamed the Michigan Legacy Tissue Program (MLTP). Originally started by Dr. Arul Chinnaiyan and Dr. Kenneth Pienta in 1996, the Rapid Autopsy Program was formed to retrieve metastatic prostate tumors for molecular study. This program continues to thrive with current input and collaboration from Dr. Jeffrey Jentzen and colleagues in Autopsy and Forensic Services.  [...]
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Study by Postdoc in Nusrat Lab Published in The Journal of Clinical Investigation

August 11, 2017 / Experimental Pathology
 
 
A study investigating fundamental mechanisms of wound healing in the gut by Miguel Quiros in Asma Nusrat’s lab  entitled, “Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling” was just published in The Journal of Clinical Investigation on August 7, 2017.  

Quiros and colleagues showed that IL-10  generated by monocytes recruited into healing wounds plays a fundamental role in [...]
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Stephanie Skala, MD and Team Publish Work on Upper Tract Urothelial Carcinoma

August 4, 2017 / Experimental Pathology
 
Dr. Stephanie Skala, Pathology House Officer IV, in collaboration with others in the Departments of Pathology, Biostatistics, Urology, Radiation Oncology, and the Michigan Center for Translational Pathology, have published work entitled [...]
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Grant Establishes Proteogenomics Center at U-M

June 27, 2017 / Experimental Pathology
Combining study of protein and genes will help researchers understand molecular basis of cancer.
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Student in Dr. Arul Chinnaiyan's Lab Awarded NIH F30 Fellowship

June 21, 2017 / Experimental Pathology
 
Ron Siebenaler, a Medical Scientist Training Program (MSTP) student in Dr. Arul Chinnaiyan’s lab at the Michigan Center for Translational Pathology, was awarded the highly competitive NIH F30 fellowship for work titled, Characterization of growth factor control of Argonaute 2 and RAS interaction. The purpose of this F30 award (Kirschstein-NRSA, dual-doctoral degree, predoctoral fellowship) is to enhance the integrated research and clinical training of promising predoctoral students [...] 
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Understanding Pediatric Brain Cancer

June 12, 2017 / Newsletter
Dr. Sriram Venneti's lab explores the interface of metabolism, epigenetics and brain development in
order to better understand and eventually treat childhood cancer.
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Team Led by Rohit Mehra, MD Publishes in the American Journal of Surgical Pathology

June 6, 2017 / Experimental Pathology
The article “Immunohistochemical evaluation of markers suggest a role for prospective FH IHC to screen cutaneous leiomyoma patients for HLRCC”, was published this month in the American Journal of Surgical Pathology (AJSP). [...]
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Nunez Lab Reports in the Journal Science: Gut Bacteria May Explain Increased Susceptibility of Newborns to Infection

April 24, 2017 / Experimental Pathology

Newborns are highly susceptible to enteric infections. It was assumed this was due to immaturity of their immune systems but new research in the laboratory of Dr. Gabriel Nunez, Paul de Kruif Professor of Academic Pathology, suggests otherwise.

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Sriram Venneti receives ASCI young Physician-Scientist Award

April 20, 2017 / Experimental Pathology
Sriram Venneti, MD, PhD, was awarded the American Society for Clinical Investigation Council Young Physician-Scientist Award. This award was initiated in 2013 and recognizes young physician-scientists who are supported by NIH K or similar significant career-development awards, are early in their first faculty appointment, and have made notable achievements in their research.
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Senior resident publishes Breast Pathology consultation practice at Michigan Medicine

April 12, 2017 / Experimental Pathology
Fourth year resident, Ellen East, MD, was recently published in Archives of Pathology & Laboratory Medicine. Under the guidance of Julie Jorns, MD, East investigated the practice of breast pathology consultation at a large tertiary care center. Learn more in Characteristics of a Breast Pathology Consultation Practice.

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A Star from the Beginning – Arul Chinnaiyan, MD, PhD leads multipronged exploration of cancer’s molecular drivers

March 16, 2017 / Experimental Pathology
Dr. Chinnaiyan knew early on that he wanted his research to have direct applications to clinical care. Now the S.P. Hicks Endowed Professor of Pathology, he runs his own laboratory and is the director of the Michigan Center for Translational Pathology. The goal of the center is to develop new molecular tests and therapeutics for human disease, with a primary focus on cancer. Read the full article in Cancer.
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Work of PhD Candidate Ana Ting featured in The Journal of Immunology

February 10, 2017 / Experimental Pathology
 

Congratulations to Molecular and Cellular Pathology PhD student, Hung-An (Ana) Ting, in the laboratory of Dr. Nicholas Lukacs, whose work on “Notch Ligand Delta-like 4 Promotes Regulatory T Cell Identity in Pulmonary Viral Infection" is featured in the “In This Issue” section of the February 15, 2017 issue of The Journal of Immunology. The “In This Issue” highlights articles considered to be among the top 10% of articles published in the journal.  Their work is on regulating lung pathology with the Notch pathway.

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Kleer lab develops model of human metaplastic breast carcinomas

December 5, 2016 / Experimental Pathology

The laboratory of Dr. Celina Kleer, Harold A. Oberman Collegiate Professor, discovered that mammary-specific knock down of CCN6 results in mammary carcinomas with features of human metaplastic carcinomas. This model may lead to discovery of new diagnostic and therapeutic targets for this rare and aggressive form of triple negative breast cancer. The article appeared in Oncogene, on the November 7th 2016 issue, and can be found at www.nature.com

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Pathology Laboratory Reports Structure of BMI1-PHC2 complex

November 10, 2016 / Experimental Pathology

The laboratory of Dr. Tomasz Cierpicki has determined the structure of BMI1 protein in complex with PHC2 and characterized its role in regulation of the architecture and activity of the PRC1. The article "BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization" has been published in Nature Communications. Co-first authors are Felicia Gray, Hyo-Je Cho and Shirish Shukla, and this is a collaborative study with Dr. Grembecka and Dr. Lawlor from the Department of Pathology.

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UM Lab’s work lands the cover of Mucosal Immunology

October 21, 2016 / Experimental Pathology

Congratulations to the Nusrat/Parkos Lab on having the cover image of the September 2016 issue of Mucosal Immunology. The image is from their article, Neutrophil interactions with epithelial expressed ICAM-1 enhances intestinal mucosal wound healing.

You can read more at nature.com.

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International collaboration leads to clues about rare cancer

May 18, 2016 / Experimental Pathology

Dr. Thomas Giordano, M.D., Ph.D, the Henry Clay Bryant Professor of Pathology, led an international study on the genomics of adrenal cancer. The project was one of the 33 projects that comprise The Cancer Genome Atlas (TCGA) project of the NCI and NHGRI. The study results were published in Cancer Cell.

View the full article online from mcancer.org OR labblog.uofmhealth.org

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Pathology Laboratory Reports New Findings in the Journal Molecular Cell

May 3, 2016 / Experimental Pathology

The laboratory of Dr. Yali Dou, Ph.D., Associate Professor of Pathology, reported new findings in the article “PRDM16 suppresses MLL1r leukemia via intrinsic histone methyltransferase activity” which was published in the journal Molecular Cell on April 27th, 2016. Dr. Bo Zhou is the first author. Other co-authors from the Department include Shirley Y. Lee, Yuqing Sun, and Rajesh C. Rao. The article can be found online at:
http://www.cell.com/

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Dr. Venneti named Kimmel Scholar for his cancer research efforts

April 22, 2016 / Experimental Pathology

Assistant Professor, Sriram Venneti, MD, PhD, was named a Kimmel Scholar by the Sidney Kimmel Foundation. The Kimmel Scholar Awards are given annually to 15 innovative research scientists and medical doctors in the U.S. who are in the early stages of their careers. Dr. Venneti will receive a $200,000 grant for his work, titled, “Metabolic regulation of epigenetics in childhood brain tumors.” Congratulations, Dr. Venneti, on being recognized as one of the country’s most promising young cancer researchers!

umhsheadlines.org

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Congratulations to Dr. Asma Nusrat

February 29, 2016 / Experimental Pathology

Congratulations to Dr. Asma Nusrat, Director of Experimental Pathology on her election as Vice President of the American Society for Investigative Pathology (ASIP). Her term is effective July 1, 2016 after which she will become President elect, then President on July 1, 2018. Dr. Nusrat has been a productive member of the ASIP community for over a decade participating in many program committees and task forces. Her commitment to enhance experimental pathology and translational medicine is admirable as evidenced by her work as the program committee chair for ASIP and PISA (Pathobiology for Investigators, Students, and Academicians) conference. Please join us in congratulating her on this prestigious national leadership appointment in Experimental Pathology

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Apply for the Pathology Proteomics Resource Facility Pilot Project Program

February 24, 2016 / Experimental Pathology

Description: The Department of Pathology invites applications from faculty with primary appointment in Pathology for proteomics related Pilot Projects that intend to use the state-of-the-art Proteomics Resource Facility (PRF) at the University of Michigan Medical School that is led by Dr. Alexey Nesvizhskii. Funds are primarily meant to help offset the cost of proteomic experiments, the results of which could potentially form the basis for or strengthen an extramural grant application. The grant is a cost share (2/3 funded by Department of Pathology and 1/3 by the investigator).

Who Can Apply: Department of Pathology Faculty

Applications will be accepted on a rolling basis and reviewed on a monthly basis. Applications received by Monday February 29, 2016 will be reviewed by March 8, 2016.

More information about this opportunity can be found by Clicking Here

 

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Pathology Laboratory Reports New Findings in the Journal Nature

January 27, 2016 / Experimental Pathology

The laboratory of Dr. Gabriel Nuñez, Paul de Kruif Professor of Pathology, reported new findings in the article “NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux” which was published as an advance online publication in the journal Nature on January 27, 2016. Dr. Yuan He is the first author. Other co-authors from the Department include Dr. Melody Zeng and Dr. Dahai Yang. The article can be found online here at http://www.nature.com.

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Arul M. Chinnaiyan, MD, PhD, was among the group of distinguished cancer scientists called to Washington DC for advice

January 11, 2016 / Experimental Pathology
Arul M. Chinnaiyan, MD, PhD, Director, Michigan Center for Translational Pathology, and S.P. Hicks Endowed Professor of Pathology; was among the group of distinguished cancer scientists called to Washington DC to give advice on how research can help bring to reality Vice President Biden's hope for a "Moon Shot Vision to cure cancer."
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Jeff Hodgin winner of prestigious Gloria Gallo Research Award

November 18, 2015 / Experimental Pathology

Last week we were thrilled to learn that Jeff Hodgin is this year’s recipient of the Gloria Gallo Research Award, an award given by the Renal Pathology Society in honor of one of its founding members for the most impactful research program. He received the award at the annual meeting of the American Society of Nephrology. In the words of Matthias Kretzler, Warner-Lambert/Parke-Davis Professor of Medicine and Jeff’s scientific mentor . . .

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Undergraduate Researchers Win Awards from AIC & AAI

November 17, 2015 / Experimental Pathology
Congratulations to Melissa Scola and Yesen Zhou, undergraduate researchers in the Department of Pathology who have won awards for their abstract submissions to this year's Autumn Immunology Conference (AIC) in Chicago, IL. Ms. Scola (LSA '16) received a "Young Investigator Award" for her abstract entitled "Interleukin 18 modulates inflammatory gene expression in macrophages via histone ubiquitination." Mr. Zhou (L
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14th Annual Pathology Research Symposium

November 2, 2015 / Experimental Pathology

Specific news image

The 14th Annual Pathology Research Symposium, organized and hosted by the Pathology Graduate Student Council, and sponsored by the Molecular and Cellular Pathology Graduate Program in the Department of Pathology at the University of Michigan will take place, Thursday, Nov. 5, 2015, from 9:30am to 4:15pm at the Palmer Commons Auditorium.

Click here to view Symposium itinerary

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Distinguished Faculty Lectureship Award in Biomedical Research goes to Eric Fearon

September 23, 2015 / Experimental Pathology

The highest honor bestowed by the University of Michigan Medical School was presented to Eric Fearon, MD, PhD as he received the Distinguished Faculty Lectureship Award. Given to an extraordinary leader in research whose scientific contributions are pivotal in advancing their field of scientific knowledge, this award also recognizes excellence in teaching, mentoring and service to the institution at large.

Click Here for more info on the event.

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Molecules and Machines

September 23, 2015 / Experimental Pathology

The 2nd Annual Protein Folding Diseases Initiative Symposium, “Molecules and Machines”, was held on Friday, September 18, 2015, at the A. Alfred Taubman Biomedical Science Research Building. 

The University of Michigan Protein Folding Diseases Initiative (PFDI), lead by Drs. Andrew Lieberman and Henry Paulson, seeks to connect the diverse campus-wide expertise on disorders of abnormal protein accumulation and perturbations in “protein quality control.” 

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Pre-doctoral Graduate Student Receiving a Ruth L. Kirschstein National Research Service Award (NRSA)

April 30, 2015 / Experimental Pathology
Congratulations to Talha Anwar, pre-doctoral graduate student in the Kleer lab on receiving a Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral MD/PhD Fellowship (F30). This three year grant will support Talha's thesis project titled "Non-canonical functions of EZH2 in triple-negative breast cancers." His project investigates the mechanistic and functional contributions of EZH2, a protein found signif
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Pre-doctoral Graduate Student Selected for 2015 National Science Foundation GRFP

April 30, 2015 / Experimental Pathology
Congratulations to Sierrah Grigsby, pre-doctoral graduate student in the Nikolovska-Coleska lab on being selected to participate in the prestigious 2015 National Science Foundation Graduate Research Fellowship Program (GRFP). Starting in May 2015 this fellowship will provide 3 years of support which will allow Sierrah to work on her thesis related to understanding the protein-protein interaction of histone methyltransferase, disruptor of tel
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Pathology Laboratory , Reported New Findings in Article

April 17, 2015 / Experimental Pathology
The laboratory of Dr. Gabriel Nuñez, Paul de Kruif Professor of Pathology, reported new findings in the article “Distinct commensals induce interleukin-1b via NLRP3 inflammasome in inflammatory monocytes to promote intestinal inflammation in response to injury” which was published in the online issue of Immunity, April 21st, 2015. Dr. Sang-Uk Seo is first author. Other coauthors from the Department
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News Article

November 14, 2014 / Experimental Pathology
The Dean's Office in the Medical School has announced this year's recipients of the "League of Research Excellence" award.  Given to honor significant contributions to the research mission of the University of Michigan through exceptional investigation and scholarship, Pathology is fortunate to have four faculty members named to this group.  We congratulate Drs. Yali Dou, Eric Fearon, Jolanta G
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